Further Studies in the Assessment of Toxic Actions: Proceedings of the European Society of Toxicology Meeting, Held in Dresden, June 11 – 13, 1979

Front Matter....Pages I-XIV
Front Matter....Pages 1-1
Assessment of Mutagenicity Tests....Pages 3-9
Testing of Medicines for Their Mutagenic Potency. Proposition from a French Working Party....Pages 10-10
Monitoring the Occupational Exposure to Mutagens by the Cytogenetic Analysis of Human Peripheral Lymphocytes in vivo....Pages 11-18
Elevated Mitotic Number in the Adrenal Cortex as a Reflection of Early Events in Growth Induction by Carcinogens and Promoters — A Possible Short-Term Assay....Pages 19-21
Sister Chromatid Exchanges in Chinese Hamster Embryonic Liver Cells Exposed Transplacentally to Bromodeoxyuridine (BrdU) and Chemical Mutagens....Pages 22-24
Differences in Carcinogenicity After Transplacental and Postnatal Administration of Drugs and Pesticides....Pages 25-28
Combination Effects in Chemical Carcinogenesis....Pages 29-40
Chromosome Aberration Tests with Chinese Hamster Cells in vitro with and without Metabolic Activation — A Comparative Study on Mutagens and Carcinogens....Pages 41-44
Ligand Binding of Safrole to Cytochrome P-450....Pages 45-48
Testing of Drugs for Combined Mutagenesis with Sodium Nitrite in the Host-mediated Assay....Pages 49-53
Biotransformation and Spectral Interaction of Xenobiotics with Subcellular Fractions from Drosophila Melanogaster....Pages 54-58
Mutagenicity of DNOC in Drosophila Melanogaster....Pages 59-61
Standardization of Clastogenicity and SCE Assays on Mammalian Cells in vitro — Results and Problems....Pages 62-62
Influence of Experimental Factors on the Mutagenicity of Vinylic Monomers....Pages 63-66
Modification of Mutagenic Activity of Anticancer Drugs....Pages 67-67
Mutagenic Activity in Foundry Air....Pages 68-72
The Effect of Carcinogens and Non-Carcinogens on Some Biochemical Features of the Mouse Lung Tissue....Pages 73-73
Attempt to Develop New Mouse Colony with High Susceptibility to Carcinogens....Pages 74-76
Metabolizing Activities of Postmitochondrial Liver Fractions (S-9) on Benzo[a]pyrene and Dimethylnitrosamine....Pages 77-80
Reduced Induction of Pyruvate Kinase After Feeding 2-Acetylaminofluorene....Pages 81-82
Front Matter....Pages 1-1
Chemical Carcinogens: Screening, Testing, Risk Assessment for Man....Pages 83-83
Studies on the Detection of Chemical Carcinogens Using a Mammalian Cell Transformation Assay. A Correlated Study of BHK Cell Transformation and Bacterial Mutagenicity....Pages 84-87
Chronic and Carcinogenic Study of Trinitroglycerin in Rats, Mice and Dogs....Pages 88-88
Induction of Pituitary Tumours and Hyperprolactinemia in Female Rats by Estrogens. The Effect of Apomorphine, Reserpine and L-DOPA....Pages 89-91
Front Matter....Pages 93-93
Immunotoxicity Assessment: Screening and Function Studies....Pages 95-108
Immunopharmacology and its Toxicological Problems....Pages 109-119
Some Approaches to Experimental Testing of Drugs for Immunotoxicity....Pages 120-131
Pharmacokinetics and Immunotoxicity....Pages 132-137
Effects of Toxicants on T-cell Subpopulations as Determined by Lymphokine Activity....Pages 138-142
A Simple Technique of Testing for the Influence of Metal Salts and Other Chemicals on Macrophages and Thymocytes in vitro....Pages 143-147
Toxicity of Organotin Compounds in Chicken and Rats....Pages 148-150
Inhibition of Immune Response by Diisopropyl Phosphorofluoridate....Pages 151-155
Thymocyte Stimulating Activity of the Serum of Rats in the Early Phase After 2-Acetylaminofluorene (AAF)-Treatment....Pages 156-158
Lysozyme (Muramidase) and Hemolytic Complement (CH 50 U) in Sera of Beagle Dogs and Minipigs After Longterm Application of Different Preparations of Estrogens and Gestagens....Pages 159-162
The Effect of Acute Administration of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on Humoral Antibody Production and Cell-Mediated Activities in Mice....Pages 163-165
Quantitative Development of Immunoglobulin (IgG) During Life-Span of Male and Female Laboratory Rat....Pages 166-166
Studies on the Action of Dimethoate on the Immune System....Pages 167-170
The Effect of DDVP, an Organophosphorus Pesticide on the Humoral and Cell-Mediated Immunity of Rabbits....Pages 171-174
The Relationship Between the Length of the Alkyl Chain of Dialkyltin Compounds and their Effects on Thymus and Bile Ducts in Mice....Pages 175-178
Allergic Encephalomyelitis in Rats — Toxicity Assay for Pertussis Vaccines....Pages 179-183
Front Matter....Pages 185-185
Some Aspects of Testing Drugs for Nephrotoxicity in Rats....Pages 187-193
Nephrotoxicity of Drugs, Evaluated by Renal Enzyme Excretion Studies....Pages 194-200
Urinary Enzyme Excretion and Changes in Renal Functions Induced by Toxic Substances or by Renal Ischemia in Rats....Pages 201-207
Stimulation of Kidney Function in Rats Injured by Nephrotoxic Agents....Pages 208-214
Relationship Between Exposure to Heavy Metals and Prevalence of Renal Dysfunction....Pages 215-218
Nephrotoxicity of the Flame Retardant Tris(2,3-Dibromopropyl)Phosphate....Pages 219-222
Evaluation of Renal Dysfunction Induced by Cadmium in Man by Determination of Enzymes and Specific Proteins in Urine....Pages 223-232
Testing of Drugs for Nephrotoxicity General Principles and Minimal Criteria....Pages 233-236
Front Matter....Pages 237-237
Hydroxyurea as a Reference Standard in Teratological Screening....Pages 239-247
Embryotoxic Effects of Post-Coital Fertility Inhibiting Steroids....Pages 248-251
Subtle Consequences of Prenatal Exposure to Low Carbon Disulphide Levels....Pages 252-254
Behaviour Teratology Tests....Pages 255-255
Testing for Embryotoxicity....Pages 256-266
Morphogenetic Systems and Screening for Embryotoxicity....Pages 267-273
The State and Future Requirements of Teratogenic Testing....Pages 274-283
Behavioural Tests in Peri- and Post-Natal Toxicity Study in Rats of Trithiozine (Tresanil)....Pages 284-287
Influence of Thalidomide on Alkaline (AP) and Acid (ACP) Phosphatase Activities in Rat Fetuses and Mothers....Pages 288-288
Experiences with a Three Step Test Scheme for Embryotoxicity and Teratogenicity....Pages 289-291
Postnatal Effects of Oral Administration of Ethylenethiourea to Rats During Late Pregnancy....Pages 292-295
Activity of Some Mixed Function Oxidases in Prenatally Carbon Disulphide (CS 2 ) Treated Rats....Pages 296-298
Front Matter....Pages 299-299
Endocrine Aspects of Ozone Exposure in Rats....Pages 301-304
Significance of Mode of Exposure in Aerosol Inhalation Toxicity Studies — Head only Versus Whole Body Exposure....Pages 305-311
Pharmacokinetic Studies with 3 H-Cytisine....Pages 312-314
Kinetics of Benzene Metabolism in Rats in Inhalation Exposure....Pages 315-317
Estimation of Occupational Exposure to Phenoxy Acids (2,4-D and 2,4,5-T)....Pages 318-321
Acrylonitrile Metabolism in the Rat....Pages 322-324
Changes of Pharmacokinetics and Metabolism of Sulfadimidine in Endotoxin Pretreated Rabbits....Pages 325-327
Effect of Hydrocortisone on Oxidative Degradation of Hexobarbital and Ethylmorphine....Pages 328-330
Study of the Protective Effect of an Anabolic Steroid, 19-Nortestosterone Phenylpropionate (19-NTPP) on the Fatty Liver Induced by High Doses of Rifampicin in the Rat....Pages 331-334
Comparative in vitro Investigations on the Dialysability of Hypnotic and Psychotropic Drugs by Hemodialysis and Controlled Sequential Ultradiffusion....Pages 335-337
The Excretion of Ascorbic Acid and Hippuric Acid in the Urine of Rats with Liver Injury....Pages 338-340
Evaluation of Liver Function Tests After Administration of Aminophenazone....Pages 341-342
Effects of Some Cholephilic Agents on Hepatic Mitochondrial Respiration and Biliary Excretion....Pages 343-345
The Fate of Propoxur in Rat....Pages 346-349
Different Role of Biotransformation in the Elimination of Some Important Pharmaceuticals and Industrial Xenobiotics....Pages 350-354
The Effect of Heavy Metals (Lead, Manganese, Mercury) on the Concentration of Free Amino Acids in the Liver of Rats....Pages 355-357
Involvement of Phenolic Metabolites in the Irreversible Protein-Binding of 14 C-Bromobenzene Catalysed by Rat Liver Microsomes....Pages 358-362
Effect of Acute Intoxication with Some Heavy Metals on Drug Metabolism....Pages 363-365
Single Intravenous Dose Kinetics and Accumulation of Atenolol in Patients with Impaired Renal Function and on Hemodialysis....Pages 366-369
Hepatic Nuclear Protein Kinases in Young Rats Pretreated with 3-Methylcholanthrene....Pages 370-372
Front Matter....Pages 299-299
Hepatic Nuclear Free and Engaged RNA-Polymerases in Young Rats Pretreated with 3-Methylcholanthrene....Pages 373-375
The Role of Metabolic Factors in the Interaction Between Opiates and Homopyrimidazoles in the Central Nervous System....Pages 376-379
Research on Pharmacokinetics During Pregnancy....Pages 380-384
Towards Standardization of the Reconstituted Mixed Function Oxidase Systems with Cytochrome P-450....Pages 385-387
Excretion of Nalidixic Acid via Mother’s Milk....Pages 388-390
Effect of Insulin on the Biliary Excretion of Some Organic Anions in Rats....Pages 391-393
Aspects of Methodology Employed in the Investigation of Combined Chemical Effects on Acute Oral Toxicity....Pages 394-395
Modification of Toxicity of Violamycin BI (VBI) by Complex Formation with DNA, Metal Ions, and by Pretreatment with α -Tocopherol....Pages 396-398
Comparative Studies on Cardiotoxicity of Some Anthracycline Antitumor Antibiotics....Pages 399-401
The Influence of Drugs on the Acute Toxicity of Cytisine....Pages 402-404
Requirements for Toxicological Evaluation of New Pesticides in Poland and the GDR....Pages 405-405
Therapy of Acute Oral Poisonings by Organic Solvents: Treatment by Activated Charcoal in Combination with Laxatives....Pages 406-409
Toxicity Evaluation of Water Soluble Substances of Dental Materials by Means of Cell Population in vitro....Pages 410-412
Cardiotoxicity of Drugs Detected on Chicken Embryos....Pages 413-414
The Effect of High Concentrations of Oxygen on Paraquat and Diquat Toxicity in Rats....Pages 415-418
Planning of Experiments for the Testing of Chronic Toxicity in Rats Taking into Account Biorhythms....Pages 419-420
Acute and Cutaneous Toxicity of β -Chlorovinyl Ketones and Aldehydes in Rodents....Pages 421-424
Cardiotoxicity from Orphenadrine Intoxications in Humans....Pages 425-427
Morphological and Biochemical Criteria for Evaluating Cytotoxic Effects of Antiviral Substances....Pages 428-430
Toxicological Effects of Steam-Sterilized High Lactose Diets on Conventional and Gnotobiotic Rats....Pages 431-434
Front Matter....Pages 299-299
Effects on Mice of Numbers of Animals per Cage: An 18-Month Study (Preliminary Results)....Pages 435-438
Toxicological Tests on the Safety of Fermosin for Pigs, a Novel Microbial Feed from Petroleum Distillate....Pages 439-442
Nutritional Toxicological Studies with Lannate: Interactions with Caffeine and Ethanol....Pages 443-445
The Occurrence of Carcinogenic Polycyclic Hydrocarbons in Foodstuffs in Hungary....Pages 446-448
An Evaluation of the Toxicity of Thiuram in Combination with Other Pesticides....Pages 449-451
Testicular Atrophy Produced by Phthalate Esters....Pages 452-455
Different Pituitary Prolactin Cell-Stimulating Effects of Various Estrogens in Female Rats....Pages 456-458
Changes in the Gonads Reproduction and Generations of White Rats Under the Effect of Some Pesticides....Pages 459-462
Clofibrate and the Development of Rats....Pages 463-465
Drug-Induced Histological Changes in Rat Seminiferous Tubular Epithelium....Pages 466-470
The Influence of Haloperidol Pretreatment on the Morphine Toxicity....Pages 471-474
Neurochemical Alterations in Rat Brain as a Test for Studying the Neurotoxicity of Organophosphorus Insecticides....Pages 475-478
Effects of Preceding Sensibilization by Reserpine and Haloperidol on Toxicity of Dopaminergic Agonists....Pages 479-481
The Use of Radionuclides for Evaluation of Dermal Irritation with Drugs....Pages 482-482
Influence of Gold Salts on the Content of Trace Elements in Serum of Patients with Rheumatoid Arthritis Under Sanocrysin Treatment....Pages 483-484
The Influence of Acetylsalicylic Acid, Phenylbutazone, Indometacin, and Flufenamic Acid on the Kinetics of Leucocytes During Acute Inflammation....Pages 485-491
Influence of Liver Enzyme Induction Caused by Diphenylhydantoin and Diazepam on Bone Mass of Rats....Pages 492-498
Back Matter....Pages 499-510