Functions of Glutathione in Liver and Kidney

Front Matter....Pages I-XIII
Front Matter....Pages 1-1
Turnover of Glutathione in Rat Liver....Pages 3-7
Regulation of the Hepatic Concentration of Reduced Glutathione....Pages 8-12
The Role of the Cystathionine Pathway in Glutathione Regulation by Isolated Hepatocytes....Pages 13-21
Physiological Significance of Elevation of Liver γ-Glutamyltranspeptidase in Late Pregnancy....Pages 22-26
Glutathione Efflux from Perfused Rat Liver and Its Relation to Glutathione Uptake by the Kidney....Pages 27-31
Unidirectional Transport of Reduced Glutathione in Rat Liver and Its Metabolization in the Extracellular Space....Pages 32-40
Front Matter....Pages 41-41
Current Status of the γ-Glutamyl Cycle....Pages 43-59
Topology and Function of Renal γ-Glutamyl Transpeptidase....Pages 60-69
The Membrane Association and Physiological Function of Rat Renal γ-Glutamyltranspeptidase....Pages 70-77
Studies on the Active Site of γ-Glutamyltransferase....Pages 78-83
The Role of Glutathione in Transport Activity in Kidney....Pages 84-91
Front Matter....Pages 93-93
Hydroperoxide Metabolism: An Overview....Pages 95-106
The Selenium Moiety of Glutathione Peroxidase....Pages 107-113
Non-Selenium-Dependent Glutathione Peroxidase....Pages 114-119
Properties of Glutathione Disulfide (GSSG) and Glutathione-S-Conjugate Release from Perfused Rat Liver....Pages 120-126
Reduction of Diazenes and Hydroperoxides by Rat Liver Mitochondria....Pages 127-138
Effect of Oxidation of Glutathione and Membrane Thiol Groups on Mitochondrial Functions....Pages 139-147
The Roles of Glutathione, Thioltransferase, and Glutathione Reductase in the Scission of Sulfur-Sulfur Bonds....Pages 148-153
Front Matter....Pages 155-155
The Glutathione Transferases in Detoxification....Pages 157-163
Functions of Glutathione in Drug Metabolism....Pages 164-175
Front Matter....Pages 155-155
Lipid Peroxidation Induced by Ethanol and Halogenated Hydrocarbons in vivo as Measured by Ethane Exhalation....Pages 176-182
Drug-induced Lipid Peroxidation in Mouse Liver....Pages 183-188
Cellular Functions in Glutathione-Depleted Hepatocytes....Pages 189-193
Glutathione and Glutathione Conjugate Metabolism in Isolated Liver and Kidney Cells....Pages 194-200
Glutathione-Requiring Enzymes in the Metabolism of Prostaglandin Endoperoxides....Pages 201-206
Back Matter....Pages 207-214