Functional Ultrastructure: Atlas of Tissue Biology and Pathology, Second Edition

Functional Ultrastructure, 2e......Page 3
ISBN 9783211993897......Page 4
Foreword......Page 6
Preface, 2e......Page 7
Preface, 1e......Page 8
Acknowlegments......Page 9
C O N T E N T S......Page 11
The Cell......Page 16
Structural Organisation of a Mammalian Cell......Page 17
Architecture of the Cell Nucleus......Page 19
Nuclear Lamina......Page 21
Detection of Sites of NA Replication and of Interphase Chromosome domains......Page 23
Nucleolus......Page 25
Changes of the Nucleolar Architecture......Page 27
Detection of Sites of RNA Synthesis......Page 29
Nuclear Pore Complexes......Page 31
Nuclear Pore Complexes: Structural Changes as Monitored by Time-Lapse Atomic Force Microscopy......Page 33
Mitosis and Cell Division......Page 35
Viral Inclusions......Page 37
Secretory Pathway of Pancreatic Acinar Cells......Page 39
Endomembrane System of Dinoflagellates......Page 41
Ribosomes, Rough Endoplasmic Reticulum......Page 43
Nuclear Envelope and Rough Endoplasmic Reticulum......Page 45
Annulate Lamellae......Page 47
Rough Endoplasmic Reticulum: Site of Protein Translocation and Initiation of Protein N-Glycosylation......Page 49
Oligosaccharide Trimming, Reglucosylation, and Protein Quality Control in the Rough Endoplasmic Reticulum......Page 51
Rough Endoplasmic Reticulum: Storage Site of Aggregates of Misfolded Glycoproteins......Page 53
Russell Bodies and Aggresomes Represent Different Types of Protein Inclusion Bodies......Page 55
Smooth Endoplasmic Reticulum......Page 57
Proliferation of the Smooth Endoplasmic Reticulum......Page 59
Pre-Golgi Intermediates......Page 61
Pre-Golgi Intermediates: Oligosaccharide Trimming and Protein Quality control......Page 63
Golgi Apparatus: A Main Crossroads Along Secretory Pathways......Page 65
Protein Secretion Visualised by Immunoelectron Microscopy......Page 67
Protein N-Glycosylation: Oligosaccharide Trimming in the Golgi Apparatus and Pre-Golgi Intermediates......Page 69
Golgo Apparatus: Site of Maturation of Aspara Gine-Linked Oligo Saccharides......Page 71
Cell Type-Related Variations in the Topography of Golgi Apparatus Glycosylation Reactions......Page 73
Cell Type-Related Differences in Oligosaccharide Structure......Page 75
Topography of Biosynthesis of Serine:Threonine-Linked Oligosaccharides......Page 77
Golgi Apparatus and TGN — Structural Considerations......Page 79
Golgi Apparatus and TGN — Secretion and Endocytosis......Page 81
Golgi Apparatus, TGN and Trans Golgi-ER......Page 83
Golgi Apparatus, TGN and Trans Golgi-ER: Tilt Series......Page 85
Structure of the TGN......Page 87
Brefeldin A-Induced Golgi Apparatus Disassembly......Page 89
Brefeldin A-Treatment: Tubulation of Golgi Apparatus and Endosomes......Page 91
Brefeldin A-Treatment: Effect on Retrograde Transport of Internalised WGA......Page 93
Brefeldin A-Treatment: Transitional ER-Elements and Pre-Golgi Intermediates......Page 95
Heat Shock Response of the Golgi Apparatus......Page 97
Golgi Apparatus Changes Upon ATP-Depletion and ATP-Replenishment......Page 99
Secretory Granules......Page 101
Secretory Granule Types......Page 103
Goblet Cell — Compound Exocytosis......Page 105
Receptor-Mediated Endocytosis Via Clathrin-Coated Vesicles and Virus Endocytosis......Page 107
Endosomes and Endocytic Pathways......Page 109
Endocytic Trans Golgi Network and Retrograde Traffic into the Golgi  Apparatus......Page 111
Tubular Pericentriolar Endosomes......Page 113
Langerhans Cells and Birbeck Granules: Antigen Presenting Dendritic Cells of the Epidermis......Page 115
Caveolae......Page 117
Fluid-Phase Endocytosis and Phagocytosis......Page 119
Lysosomes......Page 121
Lysosomes: Localisation of Acid Phosphatase, Lamp and Polylactosamine......Page 123
I-Cell Disease......Page 125
Gaucher’s disease......Page 127
Fabry’s Disease......Page 129
G[M2] Gangliosidoses......Page 131
Farber’s Disease......Page 133
Wolman’s Disease......Page 135
Cystinosis......Page 137
Autophagy: Limited Self-Digestion......Page 139
Pexophagy: Autophagy of Peroxisomes......Page 141
Mitochondria: Crista and Tubulus Types......Page 143
Abnormalities of Mitochondria......Page 145
Peroxisomes: Multitalented Organelles......Page 147
Peroxisome Biogenesis......Page 149
Peroxisomes: Adaptive Changes......Page 151
Peroxisomal Disorders......Page 153
Glycogenosis Type I......Page 155
Erythropoietic Protoporphyria......Page 157
Cytocentre, Centrosome, and Microtubules......Page 159
Effects of Microtubule Disruption......Page 161
Actin Filaments......Page 163
Intermediate Filaments......Page 165
Mallory Bodies......Page 167
The Plasma Membrane......Page 169
Cells in Culture......Page 171
Brush Cell......Page 173
Glycocalyx (Cell Coat)......Page 175
Glycocalyx: Cell Type Specificity and Domains......Page 177
Glycocalyx Changes in Tumours......Page 179
Junctional Complex......Page 181
Tight Junctions and Gap Junctions......Page 183
Tunneling Nanotubes......Page 185
Spot Desmosomes......Page 187
Selectin — Ligand-Mediated Cell-Cell Interaction......Page 189
Cellular Interdigitations......Page 191
Basal Labyrinth......Page 193
Basement Membrane......Page 195
Alport’S Syndrome (Hereditary Nephritis)......Page 197
Descemet’s Membrane......Page 199
Skin Basement Membrane and Keratinocyte Hemidesmosomes: An Epithel-Connective Tissue Junctional Complex......Page 201
Epidermolysis Bullosa Simplex......Page 203
Principles of Tissue Organization......Page 206
Pancreatic Acinus......Page 207
Acinar Centre: Acinar and Centroacinar Cells......Page 209
Pancreatic Intercalated Duct......Page 211
Submandibular Gland......Page 213
Goblet Cells — Unicellular Glands......Page 215
Parietal Cells of Stomach: Secretion of Acid......Page 217
Intercalated Cells of Kidney: Important Regulators of Acid-Base Balance......Page 219
Endocrine Secretion: Insulin-Producing Beta Cells of Islets of Langerhans......Page 221
Impaired Insulin Processing in Human Insulinoma......Page 223
Cells of the Disseminated Endocrine System......Page 225
Liver......Page 227
Liver: Hepatocytes, Kupffer cell, Cell of Ito......Page 229
Liver Epithelium: Bile Canaliculi......Page 231
Liver Epithelium: Pathway of Secretory Lipoprotein Particles......Page 233
Congenital Hepatic Fibrosis......Page 235
Choroid Plexus Ependyma......Page 237
Small Intestine: Absorptive Cells......Page 239
Small Intestine: Pathway of Lipids......Page 241
Renal Proximal Tubule: A Reabsorption Plant......Page 243
Parathyroid Hormone Response of Renal Proximal Tubules......Page 245
Photoreceptor Cells of the Retina: Signalling of Light......Page 247
Photoreceptor Cells of the Retina: Light-Induced Apoptosis......Page 249
Olfactory Epithelium......Page 251
Corneal Epithelium......Page 253
Epidermis......Page 255
Differentiation of Keratinocytes and Formation of the Epidermal Fluid Barrier......Page 257
The Tracheo-Bronchial Epithelium......Page 259
Ciliary Pathology: Immotile Cilia Syndrome and Kartagener Syndrome......Page 261
Alveoli: Gas Exchange and Host Defense......Page 263
Umbrella Cell — Surface Specialisations......Page 265
Umbrella Cell — Fusiform Vesicles......Page 267
Continuous Capillary, Weibel-Palade Bodies......Page 269
Hyaline Arteriolosclerosis......Page 271
Fenestrated Capillary......Page 273
Endothelio-Pericyte and Endothelio-Smooth Muscle Cell Interactions......Page 275
Glomerulus: A Specialised Device for Filtering......Page 277
Pathology of the Glomerular Filter: Minimal Change Glomerulopathy and Congenital Nephrotic Syndromes......Page 279
Pathology of the Glomerulus: Membranous Glomerulonephritis......Page 281
Pathology of the Glomerulus: Membranoproliferative Glomerulonephritis......Page 283
Pathology of the Glomerulus: IgA Nephropathy (Berger)......Page 285
Pathology of the Glomerulus: Chronic Allograft Glomerulopathy......Page 287
Loose Connective Tissue......Page 289
Fibroblast, Fibrocyte, Macrophage......Page 291
Collagen and Elastic Fibres......Page 293
Eosinophilic Granulocyte, Plasma Cell, Macrophage, Mast Cell......Page 295
Dense Connective Tissue: Collagen Bundles in the Cornea......Page 297
Bowman’s Layer......Page 299
Amyloidosis of Kidney......Page 301
Amyloid Fibrils: Growth as Seen by Time Lapse, Atomic Force Microscopy......Page 303
White Adipose Tissue......Page 305
Brown Adipose Tissue......Page 307
Articular Cartilage......Page 309
Osteoblasts and Osteocytes......Page 311
Osteoclast......Page 313
Myofibrils and Sarcomere......Page 315
Sarcoplasmic Reticulum, Triad, Satellite Cell......Page 317
Neuromuscular Junction......Page 319
Muscular Dystrophies......Page 321
Glycogenosis Type II (Pompe)......Page 323
Myofibrils, Intercalated Disk......Page 325
Smooth Muscle Cells, Synapse Á Distance......Page 327
CADASIL......Page 329
Central Nervous System: Neuron, Glial Cells......Page 331
Blood-Brain Barrier, Synapses......Page 333
Structure of the Synaptic Terminal......Page 335
Unmyelinated Nerve Fibre......Page 337
Peripheral Nerve: Connective Tissue Components......Page 339
Myelinated Nerve Fibre, Myelin......Page 341
Node of Ranvier......Page 343
Axonal Degeneration......Page 345
Neuroaxonal Dystrophy......Page 347
Neuropathies Associated with Dysproteinaemias......Page 349
Metachromatic Leukodystrophy......Page 351
Neuronal Ceroid Lipofuscinosis......Page 353
Red Blood Cells and Cells of the Erythroid Lineage......Page 355
Neutrophilic Granulocyte......Page 357
Eosinophilic Granulocyte......Page 359
Basophilic Granulocyte......Page 361
Monocyte......Page 363
Lymphocyte......Page 365
Megakaryocyte and Thrombocyte......Page 367
Thrombocytes......Page 369
Index......Page 372