Frontiers of Cellular Bioenergetics: Molecular Biology, Biochemistry, and Physiopathology

Front Matter....Pages i-xxx
The Mitochondrial and Bacterial Respiratory Chains....Pages 1-22
The Mitochondrial Enzymes of Oxidative Phosphorylation....Pages 23-47
Proton Pumps of Respiratory Chain Enzymes....Pages 49-87
Uncoupling of Respiration and Phosphorylation....Pages 89-118
Crystallization, Structure, and Possible Mechanism of Action of Cytochrome c Oxidase from the Soil Bacterium Paracoccus denitrificans ....Pages 119-130
The Structure of Crystalline Bovine Heart Cytochrome c Oxidase....Pages 131-156
Electron and Proton Transfer in Heme-Copper Oxidases....Pages 157-178
Mechanism of Proton-Motive Activity of Heme-Copper Oxidases....Pages 179-192
Oxygen Reduction and Proton Translocation by the Heme-Copper Oxidases....Pages 193-217
Transient Spectroscopy of the Reaction between Cytochrome c Oxidase and Nitric Oxide....Pages 219-232
Energy Transduction in Mitochondrial Respiration by the Proton-Motive Q-Cycle Mechanism of the Cytochrome bc 1 Complex....Pages 233-261
The Crystal Structure of Mitochondrial Cytochrome bc 1 Complex....Pages 263-289
Structural Aspects of the Cytochrome bc 1 Complex....Pages 291-324
Structure, Function, and Biogenesis of Respiratory Complex I....Pages 325-360
Structure of F 1 -ATPase and the Mechanism of ATP Synthesis— Hydrolysis....Pages 361-376
Mechanism of ATP Synthesis by Mitochondrial ATP Synthase....Pages 377-398
Mutational Analysis of ATP Synthase An Approach to Catalysis and Energy Coupling....Pages 399-421
Analysis of the Nucleotide Binding Sites of ATP Synthase and Consequences for the Catalytic Mechanism....Pages 423-457
Coupling Structures and Mechanisms in the Stalk of the Bovine Mitochondrial F 0 F 1 -ATP Synthase....Pages 459-487
The Mitochondrial Carrier Protein Family....Pages 489-519
Structure and Evolution of Metazoan Mitochondrial Genome....Pages 521-551
Nuclear Transcription Factors in Cytochrome c and Cytochrome Oxidase Expression....Pages 553-591
Suppressor Genetics of the Mitochondrial Energy Transducing System The Cytochrome bc 1 Complex....Pages 593-619
Tissue-Specific Expression of Cytochrome c Oxidase Isoforms and Role in Nonshivering Thermogenesis....Pages 621-633
Mitochondrial DNA Mutations and Nuclear Mitochondrial Interactions in Human Disease....Pages 635-663
Strategy toward Gene Therapy of Mitochondrial DNA Disorders....Pages 665-675
The F 0 F 1 -ATP Synthase in Cell Proliferation and Aging....Pages 677-692
Age-Linked Changes in the Genotype and Phenotype of Mitochondria....Pages 693-727
Nucleus-Driven Lesions of mtDNA and Disorders of Nucleus-Encoded Energy Genes....Pages 729-749
Aging and Degenerative Diseases....Pages 751-772
Perspectives on the Permeability Transition Pore, a Mitochondrial Channel Involved in Cell Death....Pages 773-795
Back Matter....Pages 797-801