Frontiers in Neutron Capture Therapy: Volume 1

Front Matter....Pages i-xlii
Front Matter....Pages 3-3
Monochromatic X-Rays, Slow Neutrons, and Radionuclides for Targeted Radiotherapy....Pages 5-12
Current Trends and Progress in the Physics of BNCT....Pages 13-21
Chemistry and Pharmacology of Agents for BNCT....Pages 23-34
Front Matter....Pages 35-35
The Harvard-MIT BNCT Program....Pages 37-60
Boron Neutron Capture Therapy for Glioblastoma Multiforme....Pages 61-72
Boron Neutron Capture Therapy....Pages 73-79
Status Report on the European Clinical Trial of BNCT at Petten (EORTC Protocol 11961)....Pages 81-86
Case Studies of Patients with Glioblastoma Multiforme Treated with Boron Neutron Capture Therapy at the Brookhaven Medical Research Reactor....Pages 87-92
Patterns of Tumor Progression Following BNCT of Glioblastoma Multiforme....Pages 93-97
Intercomparison of Three Epithermal Neutron-Based Clinical Trials of BNCT....Pages 99-103
Report on the First Patient Group of the European Phase I Trial (EORTC Protocol 11961) at the High Flux Reactor Petten....Pages 105-111
Quality Management at the European BNCT Center in Petten....Pages 113-121
Psychological Aspects of the Patient Treatment by BNCT at Petten....Pages 123-127
At the Threshold of Clinical Trials....Pages 129-131
An Autopsy Report of a Glioblastoma Case after Boron Neutron Capture Therapy....Pages 133-139
Long Term Follow up in Patients Who Underwent Boron Neutron Capture Therapy....Pages 141-144
A Case of Astrocytoma....Pages 145-150
Front Matter....Pages 151-151
Treatment Planning for the First Group of Patients in the European Glioma Trial at the HFR Petten....Pages 153-159
Quality Assurance for Clinical Dosimetry of the European Trial on BNCT in Petten....Pages 161-171
Medical Image Transfer and Conversion for BNCT Treatment Planning at Petten....Pages 173-177
Front Matter....Pages 151-151
Patient Positioning at the HFR Petten....Pages 179-183
Treatment Planning Based on Dynamic Positron Emission Tomography for Boron Neutron Capture Therapy for Glioblastoma Multiforme....Pages 185-188
Acceleration of MCNP-Based Treatment Planning and the Application for In Vivo Boron Determination by the Gamma-Ray Telescope....Pages 189-193
Integrated Medical Image Registration, Patient Positioning, and Patient Monitoring for Cranial BNCT....Pages 195-199
Treatment Plan Evaluation in Boron Neutron Capture Therapy....Pages 201-206
A Comparison of Two BNCT Treatment Planning Programs....Pages 207-212
Three Dose Calculation Codes Applied to Neutron Transport in BNCT....Pages 213-217
Source Characterization for the rtt_MC Treatment Planning Program at FiR 1....Pages 219-224
“CARONTE”, A Treatment Planning System Based on Real Macroscopic Boron Distribution and MCNP-4A Code....Pages 225-230
CASE-MATE: Computer-Aided Cell Seeding, Microcloning, Analysis, and Telemetric Evaluation Applied to Neutron Capture Therapy....Pages 231-235
Standard Operating Procedures Followed by the Petten BNC-Team during Patient Treatment....Pages 237-241
Predicting Boron-10 Concentrations in Normal Brain and GBM from Blood Measurements....Pages 243-247
A Pharmacokinetic Model for the Concentration of Boron-10 in Blood Following Boronophenylalanine-Fructose Administration in Humans....Pages 249-255
Quality Control for Na 2 B 12 H 11 SH, a Drug for Boron Neutron Capture Therapy in EORTC Trial 11961....Pages 257-260
The Pharmacokinetics of BSH Following Single and Multiple Administrations....Pages 261-264
Front Matter....Pages 265-265
Metamorphosis of a 35 Year-Old TRIGA Reactor into a Modern BNCT Facility....Pages 267-275
Status of the Medical Irradiation Facility at JRR-4....Pages 277-281
Clinical Protocol Using New Neutron Irradiation Facility (JRR4) at JAERI....Pages 283-287
Upgrade of the Epithermal Neutron Beam Using 235 U Fission Plates at Brookhaven Medical Research Reactor (BMRR)....Pages 289-294
TRIGA ® Fuel Based Converter Assembly Design for a Dual-Mode Neutron Beam System at the McClellan Nuclear Radiation Center....Pages 295-300
Front Matter....Pages 265-265
BNCT Filter Design Studies at the CEA-Saclay ISIS Research Reactor....Pages 301-305
Preparation of a Beam Tube of the Portuguese Research Reactor to be Used in BNC and Other Activites....Pages 307-311
NCT Facility Development and Beam Characterisation at the RA-6 Reactor....Pages 313-317
A NCT Facility Design at HANARO....Pages 319-323
Beam Collimator Design for the Epithermal Neutron Beam at the Tsing Hua Open-Pool Reactor (THOR)....Pages 325-329
The Usage of the KUR Advanced Clinical Irradiation System for NCT under the KUR Continous Operation....Pages 331-335
Feasibility of the Utilization of BNCT in Thermalizing Column of TRIGA Reactor....Pages 337-343
The Characteristics of the Updated Heavy Water Facility of the Kyoto University Reactor (II) (Neutron Energy Spectra for Several Irradiation Modes)....Pages 345-349
The Test-Type Hyper-Thermal Neutron Generator for Neutron Capture Therapy....Pages 351-355
What are the Best Energies for Neutron Production for NCT?....Pages 357-361
The Use of Polytetrafluoroethylene (Teflon®) Containing Filter/ Moderators for Epithermal Neutron Beam Production....Pages 363-367
Three-Dimensional Measurement of Thermal Neutron Absorbed Dose for BNCT Experimental Program, Performed in a Fast Research Reactor....Pages 369-374
Validation of the Specification of the Epithermal Neutron Beam for Boron Neutron Capture at the HFR Petten....Pages 375-380
Determination of the Geometric and Spectral Characteristics of BNCT Beam (Neutron and Gamma-Ray)....Pages 381-389
BNCT Beam Quality Maximization....Pages 391-405
A Biological Comparison of Neutron Beams Used for BNCT Research....Pages 407-411
A Comparison of Neutron Fields for BNCT....Pages 413-417
The BNCT Project in the Czech Republic before the Start of Clinical Treatment....Pages 419-424
The Russian Project on Neutron Capture Therapy for Cancer....Pages 425-432
Front Matter....Pages 433-433
Development of an Accelerator-Based BNCT Facility at the Berkeley Lab....Pages 435-440
Front Matter....Pages 433-433
The Relationship Between BNCT Neutron Beam Parameters and Treatment Planning Figures-Of-Merit....Pages 441-447
Development of a High-Power Water-Cooled Beryllium Target for use in Accelerator-Based Boron Neutron Capture Therapy....Pages 449-453
A Sealed-Accelerator-Tube Neutron Generator for Boron Neutron Capture Therapy Application....Pages 455-459
Construction of an Accelerator-Based Neutron Beamline for Treatment of Arthritic Joints....Pages 461-467
Use of the 9 Be(d,n) Nuclear Reaction for Accelerator-Based Boron Neutron Capture Therapy....Pages 469-474
An Experimental Program for BNCT Using a Thermal Accelerator-Based Source and the Epithermal Facility at the Tapiro Reactor....Pages 475-482
Investigation of 2 H(d,n) 3 He and 3 H(d,n) 4 He Fusion Reactions as Alternative Neutron Sources for BNCT....Pages 483-488
Spectral Characterization of Accelerator-Based Beams for BNCT Using Neutron Activation Foils....Pages 489-494
Preliminary Study on Accelerator-Based Neutron Fields for NCT....Pages 495-501
Experimental In-Phantom Dosimetry of the 7 Li(p,n) Reaction near Threshold....Pages 503-508
Feasibility of a Near-Threshold BNCT Neutron Source Based on Phantom Dosimetry....Pages 509-514
Analysis of Accelerator Based Neutron Spectra for BNCT Using Proton Recoil Spectroscopy....Pages 515-521
Energy Optimization of Epithermal Neutron Beams for Accelerator-Based BNCT....Pages 523-528
Applications of Californium-252 and the Californium User Facility for Neutron Capture Therapy Research....Pages 529-534
Neutronic Design of a 252 Cf- 235 U Epithermal Irradiation Facility Applied to BNCT....Pages 535-538
Measurement of Fast Neutron, Gamma, and Thermal Neutron Dose Around a Cf-252 Source....Pages 539-545
Calculated Boron Neutron Capture Dose Enhancement in ICRU 44 Brain with 252 Cf....Pages 547-554
Front Matter....Pages 555-555
Semiconductor Dosimetry in BNCT....Pages 557-563
Reporting a BNCT Irradiation....Pages 565-569
Radiation Risks from p -Boronophenylalanine-Mediated BNCT for Glioblastoma Multiforme....Pages 571-574
Front Matter....Pages 555-555
Nominal Effective Radiation Doses Delivered to the Tumor and Different Parts of the Normal Brain During BNCT for Glioblastoma Multiforme....Pages 575-579
Microdosimetry Studies at the BMRR and the MITR-II Using Miniature Tissue-Equivalent Proportional Counters....Pages 581-586
Radiation Dosimetry for NCT Facilities at the Brookhaven Medical Research Reactor....Pages 587-591
 In Vivo Determination of Boron in Patients During BNCT in Petten by Means of the Gamma-Ray Telescope....Pages 593-598
MCNP Enhancements, Parallel Computing, and Error Analysis for BNCT a ....Pages 599-604
Calculation of Absorbed Dose Distributions Using Removal- Diffusion Theory for BNCT Treatment Planning....Pages 605-609
The Development of a Computational Dosimetry System for BNCT at JAERI....Pages 611-614
Application of Silicon Diode Arrays for Microdosimetry in BNCT and FNT....Pages 615-621
Shielding Design and Calculations for the Finnish BNCT Facility....Pages 623-628
NCT Treatment Room Dose Determinations Using the Monte Carlo Adjoint Shielding (MASH) Method....Pages 629-633
Radioprotection for Patients and Staff during BNCT at the HFR Petten....Pages 635-639
Real-Time Absorbed Dose Estimation System for BNCT by PG-SPECT....Pages 641-645
Utility of Measured Microdosimetric Single Event Spectra in Interpreting Quality of Radiation Fields Used in BNCT....Pages 647-651
Cell Cluster Models for Microdosimetry....Pages 653-658
Measurements of Phantom Dose Distributions at the Finnish BNCT Facility....Pages 659-664
Radioprotection Dosimetry in the European Trial on BNCT Studied by an Anthropomorphic Phantom....Pages 665-670
Development of a Neutron Energy-Biased in-Air Figure-of-Merit for Predicting in-Phantom BNCT Neutron Beam Characteristics....Pages 671-679
Reference Phantom Design for the Birmingham BNCT Project....Pages 681-686
Absorbed Dose Estimates with a High Resolution Voxel-Based Head Phantom....Pages 687-692
Front Matter....Pages 693-693
Neutron Capture Therapy (NCT) Enhancement of Fast Neutron Radiotherapy at the University of Washington....Pages 695-702
Front Matter....Pages 693-693
Progress towards Boron Neutron Capture Enhancement of Fast Neutron Therapy at the Harper Hospital Neutron Therapy Facility....Pages 703-707
Characterization of a Modified Fast Neutron Beam for Boron Neutron Capture Enhancement of Fast Neutron Therapy....Pages 709-713
Modifications to rtt_MC for Fast Neutron Therapy Treatment Planning....Pages 715-722
Treatment Planning for Boron Neutron Capture Enhanced Fast Neutron Therapy....Pages 723-728
Modification of the University of Washington Neutron Radiotherapy Facility for Optimization of Neutron-Capture-Enhanced Fast Neutron Therapy....Pages 729-734
Boron Neutron Capture-Enhanced Fast Neutron Therapy (BNC/FNT) for Non-Small Cell Lung Cancer in Canine Patients....Pages 735-739
BNCEFN Optimisation with Lead Blocks Collimation and Graphite Embedding....Pages 741-746
On the Study of a Laminated Beryllium/Tungsten Target for Boron Neutron Capture Enhanced Fast-Neutron Therapy....Pages 747-753
Progress Toward Fast Neutron Relative Biological Effectiveness Determination Via Proton Bombardment of V79 Cells....Pages 755-759
Front Matter....Pages 763-763
A Concise Synthesis of Enantiomerically Pure L -(4-Boronophenyl)Alanine from L -Tyrosine....Pages 765-768
The Complexation of p -Boronophenylalanine with Alcohols or Carboxylic Acids Studied by Zone Electrophoresis....Pages 769-773
Recent Developments in the Chemistry of [B 12 H 12 ] 2- ....Pages 775-778
Synthesis of Schiff Bases and Monoalkylamino Derivatives on the Base of Amino- closo -Dodecaborate(1-) Anion [B 12 H 11 NH 3 ] - ....Pages 779-783
Potential BNCT Agents....Pages 785-790
Borylated Ferrocenium Compounds....Pages 791-795
Enantioselective Syntheses of 10 B-Enriched L- and D-Carboranylalanine and Their Radiobiological Evaluation in V-79 Chinese Hamster Cells....Pages 797-802
A Potential New BNCT Agent....Pages 803-806
Benzoquinone Oxidation of the [ ae -B 20 H 17 NH 3 ] 3- and [ ae -B 20 H 17 OH] 4- Ions....Pages 807-811
BSMel: An Aromatic Amino Acid Analog of High Boron Content, Easily Prepared from B-10 Enriched and Stereochemically Pure Precursors....Pages 813-817
Current Status of Selenium Coupling to Hoechst-Carborane....Pages 819-823
Front Matter....Pages 763-763
New Synthesis of Boronated Chlorins with Different Lipophilicity....Pages 825-829
Fluorination of p -Boronophenylalanine....Pages 831-834
Radioiodination Techniques for Aromatic Amino Acids....Pages 835-838
Synthetic Approaches to a Novel Iodinated Analogue of BPA....Pages 839-841
Design of Boron- and Gadolinium-Containing Agents for NCT....Pages 843-846
Front Matter....Pages 847-847
On-Line Boron-10 Determination from Blood Samples by ICP-MS....Pages 849-851
The Role of Dynamic Positron Emission Tomography for Quantifying Boron-10 in Vivo Using the Fructose Complex of Fluorine-18 Labeled Boronophenylalanine....Pages 853-856
Structure Determination of p -Boronophenylalanine-Fructose Complex Using 1 J cc Coupling Constants....Pages 857-861
Simultaneous Determination of p -Boronophenylalanine and Boric Acid Using 11 B-NMR....Pages 863-868
Structure of the BPA-Fructose Complex....Pages 869-874
Proton MR Spectroscopic Measurement of p -Boronophenylalanine for in Vivo Pharmacokinetic Studies....Pages 875-881
Subcellular Localization of BSH-Containing and Non-Boron- Containing Chlorin Derivatives in Living Cells Using Confocal Laser Scanning Microscopy....Pages 883-886
Quantitative Analysis of Boron in Co-Cultures of Human Glioblastoma T98G Cells and Normal Cell Lines within the Same Field of View of Ion Microscopy Imaging....Pages 887-891
Ion Microscopy Imaging of Boron in Animal Tissue Sections for Neutron Capture Therapy....Pages 893-897
Ion Microscopy Imaging of Boron from p -Boronophenylalanine in Surgically Acquired Samples of Human Brain Tumor Tissue....Pages 899-903
 In Vitro Exposure of Human T98G Glioblastoma Cells to Mixed BNCT Drugs....Pages 905-909
A Combination of Immunohistochemistry and Photoelectron Spectromicroscopy for Investigations of Subcellular Boron Distribution....Pages 911-915
A Method for Determining the Concentration of Boron in Blood by the Measurement of Thermal Neutron Flux Depression....Pages 917-921
Non-Invasive Quantification of Gadolinium Uptake in Tumors....Pages 923-926
Subcellular Biodistribution of Na 2 B 12 H 11 SH (BSH) in Rat Glioma Model....Pages 927-931
Front Matter....Pages 847-847
Determination of BSH (Na 2 B 12 H 11 SH) Absorbed in Tumor Tissue....Pages 933-937
Detection of 10 B Distributions in Histological Samples by Neutron Capture Autoradiography Using Cold Neutron Beams and Photoluminescent Imaging Plates....Pages 939-943
Alpha-Autoradiographic Determination of 10 B Concentrations in Cancer Bearing Mice for Boron Neutron-Capture Therapy....Pages 945-951
Front Matter....Pages 953-953
A New Simplified System for the Evaluation of BNCT Pharmaceuticals....Pages 955-957
Compartmental and Non-Compartmental Methods in Studying the Kinetics of Boron-10 after Boronophenylalanine Fructose Complex (BPA-F)-Infusion in Dogs....Pages 959-963
Time-Dependent Biodistribution of BPA-F in Normal and Tumor Brain Tissues in Mice....Pages 965-971
Boron-10 Distribution of p -Boronophenylalanine in the Experimental Brain Tumor in the Rats....Pages 973-977
BPA Uptake and Efflux through the Cellular Membrane....Pages 979-983
A Further Mechanism Study of Boron Accumulation to and Release from Melanoma with p -Boronophenylalanine....Pages 985-989
Enhanced Uptake of Boronophenylalanine and Efficacy of BNCT in F98 Glioma Bearing Rats Following Administration of Cereport™....Pages 991-995
Effect of Dose and Infusion Time on the Delivery of p - Boronophenylalanine for Neutron Capture Therapy....Pages 997-1002
 In Vitro Uptake Study of 5-Carboranyl Uridine and Its Derivatives....Pages 1003-1008
Evaluation of Carboranyl 2′-Deoxyuridine Derivatives as Substrates for Human Thymidine Kinases 1 and 2....Pages 1009-1013
 In Vivo and In Vitro Uptake Study of Boronated Porphyrins for Neutron Capture Therapy....Pages 1015-1020
Toxicology of BOPP in Large Animals....Pages 1021-1026
Biodistribution Study of Novel Dodecaborate-Phthalocyanines in the B-16 Mouse Melanoma Model....Pages 1027-1032
Investigations of the Interaction of Phospholipids with Mercaptoundecahydro- closo -Dodecaborate (2-) (BSH) and Dodecahydro- closo -Dodecaborate (2-) (B 12 H 12 2- )....Pages 1033-1037
Membrane Binding of Na 2 B 12 H 11 SH (BSH) with Phosphatidylcholine in Boron Neutron Capture Therapy....Pages 1039-1044
Investigation of the Toxicity and Cellular Uptake of Na 4 [B 20 H 17 SH] in EMT6 Cells....Pages 1045-1049
Evaluation of the Binding of Polyhedral Borane Compounds to Intracellular Protein Moieties and Monomeric Amino Acids....Pages 1051-1055
Front Matter....Pages 953-953
Cremophor EL Alters Uptake, Retention, Distribution, and Toxicity of the Boron Containing Ether Lipid....Pages 1057-1061
Analysis of in Vivo Uptake for Boron Neutron Capture Synovectomy....Pages 1063-1066
Front Matter....Pages 1067-1067
SLT-Particles for Two-Step Targeting in Boron Neutron Capture Therapy....Pages 1069-1075
Application of 10 B Entrapped Liposome to Boron Neutron Capture Therapy for Pancreatic Cancer Model in Vivo ....Pages 1077-1083
LDL Receptor Status of Human Glioblastoma Cells....Pages 1085-1088
The Advantage of Porphyrin for BNCT from the Point of View of Cell Cycle....Pages 1089-1092
Strategies to Improve the Efficacy of Neutron Capture Therapy of Brain Tumors by Optimizing Delivery of Boron Compounds....Pages 1093-1101
Boron-Rich Oligomeric Phosphate Diesters that Target the Cell Nucleus in Vitro ....Pages 1103-1107
Biodistribution of Technetium-99m Labeled Epidermal Growth Factor Following Intracarotid Injection into Rats Bearing Intracerebral EGF Receptor (+) Gliomas....Pages 1109-1113
Biological Evaluation of Boronated Polyamines as Potential Agents for BNCT....Pages 1115-1119
Preclinical Development of β-D-5- o -Carboranyl-2′-Deoxyuridine (D-CDU) for the Treatment of Malignant Brain Tumors....Pages 1121-1124
Selective Tumor Uptake of Boronophenylalanine-Fructose (BPA-F) in an Animal Model of Hepatic Colorectal Metastases....Pages 1125-1129
Front Matter....Pages 1131-1131
BNCT Microdosimetry of a Rat Glioma Model with BPA-F or BSH....Pages 1133-1138
Determination of the Compound Factors of BSH and BPA for Glial Progenitor Survival in a Small Animal Model Using Thermal and Epithermal Neutron Irradiation....Pages 1139-1143
Analytical Evaluating Method of 10 B(n,αγ) 7 Li Prompt Gamma-Ray Spectrum for Measuring Absorbed Dose Distribution in Boron Neutron Capture Therapy....Pages 1145-1149
Modeling the Impact of Near-Threshold 7 Li(p,n) 7 Be Generated, Fast Neutron Beams on Boron Drug Distribution Requirements for BNCT....Pages 1151-1157
Computational Dosimetry for Boron Neutron Capture Synovectomy....Pages 1159-1163
Application of Thermoluminescent Dosimeters to Mixed Neutron- Gamma Dosimetry for BNCT....Pages 1165-1173
Semiconductor Detectors for In-Phantom Thermal Neutron Flux and Boron Dose Measurements in BNCT and Fast Neutron Therapy....Pages 1175-1180
Determination of an RBE for an Epithermal Neutron Beam for BNCT from Microdosimetric Measurements....Pages 1181-1185
Front Matter....Pages 1131-1131
Effects of Neutron Collimation, Beam Size, and Spectrum on In-Phantom Performance of Realistic Epithermal Neutron Beams for BNCT....Pages 1187-1193
Dose Distribution in 157 Gd and 10 B Containing Phantoms Subsequent to Irradiation with Thermal Neutrons....Pages 1195-1201
 252 Cf Mixed-Field Dosimetry for a Variety of Source Geometries and Phantom Materials for Clinical Brachytherapy....Pages 1203-1210
 157 Gd Photon Dose Enhancement from a Neutron Emitting 252 Cf Point Source....Pages 1211-1217
Theoretical Cell Survival Probability for Preclinical Evaluation of BNCT Treatment Conditions....Pages 1219-1224
A Monte Carlo Calculation of the Change in Dosimetric Properties on the Usage of Heavy Water for Boron Neutron Capture Therapy....Pages 1225-1229
Front Matter....Pages 1231-1231
Large Animal Model for Healthy Tissue Tolerance Study in BNCT....Pages 1233-1238
A Large Animal Model Study Investigating Potential BNCT Retreatment Using BSH....Pages 1239-1243
Dosimetry Chain for the Dogs Irradiated in the Epithermal Neutron Beam at the Finnish BNCT Facility....Pages 1245-1250
 In Vivo Dosimetry of the Dog Irradiations at the Finnish BNCT Facility....Pages 1251-1256
Survival after BNCT in Combination with Surgery for Dogs with Spontaneous Brain Tumors....Pages 1257-1261
Quantitative MRI in Assessing Irradiation Effect in Dog Brain....Pages 1263-1267
Irradiation of Dog Brain with Single Doses of X-Rays....Pages 1269-1272
A Rat Model of Oral Mucosal Response to Boron Neutron Capture Irradiation....Pages 1273-1277
Split-Dose BNCT Irradiations of Rat Oral Mucosa and Rat Brain Tumor Using BPA....Pages 1279-1283
Efficacy of Boron Neutron-Capture Therapy Using a Carborane- Containing Tetraphenylporphyrin in Mice Bearing EMT-6 Tumors....Pages 1285-1291
Apoptosis of Tumor Cells in Response to Boron Neutron Capture Therapy....Pages 1293-1297
Apoptosis Induced by Boron Neutron Capture Therapy for Brain Tumors....Pages 1299-1304
Cell Cycle Change of 9L Glioma Cell after in Vitro Boron Neutron Capture Therapy....Pages 1305-1309
Radiobiological Effects of Boronated Porphyrin (STA-BX909) Compared to BSH in Cultured Glioma Cell Line....Pages 1311-1316
Front Matter....Pages 1231-1231
Mutagenic Effects at HPRT Locus in Chinese Hamster Ovary (CHO) Cells Induced by Epi-Thermal and Thermal Neutrons....Pages 1317-1321
Evaluation of Neurotoxicity and Radiation Effects of BNCT in Rats Following Blood-Brain Barrier Disruption and Intracarotid Injection of BPA or BSH....Pages 1323-1327
Cell Survival Following in Vitro Irradiation at Depth in a Lucite Phantom as a Measure of Epithermal Beam RBE....Pages 1329-1333
Applicability of Combination with Tirapazamine in Boron Neutron Capture Therapy....Pages 1335-1341
Behaviors of Cells in Different Proliferative States within Solid Tumors in Boron and Gadolinium Neutron Capture Therapy When Irradiated with Two Different Cadmium Ratio Neutrons....Pages 1343-1350
Depth-Dose Evaluation for Liver Cancer Treatment by BNCT and GDNCT Using an Epithermal Neutron Beam....Pages 1351-1356
A Compact Cell Culture Disc for Neutron Capture Radiography....Pages 1357-1361
Front Matter....Pages 1363-1363
Current Clinical Paradigms in Melanoma BNCT....Pages 1365-1382
BNCT Beyond Glioma Treatment....Pages 1383-1387
Progress in the Development of Boron Neutron Capture Synovectomy for the Treatment of Rheumatoid Arthritis....Pages 1389-1397
Which is the Best Nuclide for NCT?....Pages 1399-1403
NCT with Several Agents....Pages 1405-1409
Energy Deposited by Electrons in DNA Following n+Gd Interaction....Pages 1411-1415
Neutron Capture Therapy (BNCT) and Photodynamic Therapy (PDT) Can Both be Accomplished with a Single Compound....Pages 1417-1421
BNCT for the Prevention of Restenosis Following Angioplasty....Pages 1423-1426
Operative Modalities and Effects of BNCT on Liver Metastases of Colon Adenocarcinoma....Pages 1427-1440
Back Matter....Pages 1141-li