Frontiers in Neuropsychiatric Research

Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Noradrenergic signal transfer as a target of antidepressant therapy....Pages 3-17
Trans-synaptic mechanisms in the action of imipramine....Pages 19-31
Regional variations in 5-HT receptor populations and in 3H-imipramine binding sites in their responses to chronic antidepressant treatment....Pages 33-54
The possible role of central epinephrine, ∝2-adrenoreceptors and presynaptic dopamine receptors in affective disorders....Pages 55-64
Molecular aspects of regulation of ∝2-adrenergic receptors....Pages 65-82
Front Matter....Pages 83-83
Serotonin selective reuptake inhibitors — relationship between chemical structure and pharmacological effects....Pages 85-92
Effects of chronic administration of antidepressant drugs on central serotonergic receptor mechanisms....Pages 93-108
Neurochemical effects of the atypical antidepressant diclofensine in the rat....Pages 109-120
Oxaprotiline and its enantiomers: do they open new avenues in the research on the mode of action of antidepressants?....Pages 121-134
Effects of single and multiple doses of antidepressant drugs on the 3H-spiperone-labelled serotonin receptors in the frontal cortex of the rat....Pages 135-143
Relationship between adaptive changes in brain ∝2- and β-adrenergic receptors following repeated imipramine, yohimbine and electroconvulsive shock treatment to rats....Pages 145-158
A review of the properties of a new specific 5-HT reuptake inhibitor — fluvoxamine maleate....Pages 159-173
Biochemical and physiological mechanisms of action of carbamazepine in affective illness....Pages 175-192
Front Matter....Pages 193-193
Bupropion: an empirical pharmacological approach to drug development....Pages 195-224
Antidepressant and potential antimanic actions of GABA receptor agonists....Pages 225-232
Fluoxetine: a clinically effective non-tricyclic antidepressant....Pages 233-240
The dexamethasone suppression test as a research variable....Pages 241-250
Front Matter....Pages 251-251
Progress in pharmacotherapy of depression: research implications....Pages 253-265
Relationship of anxiety disorders to affective disorders....Pages 267-274
Application of sleep investigations in understanding antidepressant drug — clinical drug interactions....Pages 275-286
Front Matter....Pages 287-287
Biochemical aspects in striatal dopamine receptor desensitization....Pages 289-300
Receptor—receptor interactions: possible new mechanisms for the action of some antidepressant drugs....Pages 301-318
A double-blind comparative trial of oxaprotiline with amitriptyline and placebo in outpatients with moderate depression: relationship of urinary MHPG levels....Pages 319-330
Platelet ∝2-adrenergic receptor activity in clinical studies of depression....Pages 331-356
The olfactory bulbectomized rat as a model of depression....Pages 357-372
Closing remarks....Pages 373-374
Back Matter....Pages 375-396