Frontiers in Natural Product Chemistry 4

Intro
 CONTENTS
 PREFACE
 List of Contributors
 Plant-Based Antiamoebic Natural Products: Literature Review and Recent Developments
 Neelam Bharti1,*, Prabhu P. Mohapatra2 and Shailendra Singh3
 INTRODUCTION AND BACKGROUND
 Search for Herbal Antiamoebic Compounds
 Standard Extraction Procedure
 Alkaloids
 Terpenes and Quassinoids
 Flavonoids and Iridoids
 Miscellaneous
 CONCLUSION AND OUTLOOK
 DISCLOSURE
 CONSENT FOR PUBLICATION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENT
 REFERENCES
 From Plant to Bench: Natural Products as Source for Analgesic Drug Development. Rita Turnaturi1,*, Lorella Pasquinucci1 and Carmela Parenti2INTRODUCTION
 SALVINORIN A
 Traditional Use and Botanical Description
 Analgesic Effect
 Other Effects
 Constituents of Salvia Divinorum
 Salvinorin A Derivatives
 1. Structural Derivatization of the C-2 Position.
 MOPr ligands
 2. Structural Modifications of the Tricyclic Trans-Decalin Core
 Modifications to the C-12 Furan Ring
 MITRAGYNINE
 Botanical Description and Traditional Use
 Analgesic Effect
 Anti-inflammatory Effects
 Putative Addictive Properties
 Constituents of Mitragyna Speciosa
 Structure−Activity Relationship The Psychological HypothesisThe Olfactory Function of Aromatherapy (Smell)
 Improving Mood and Cognitive Function using Essential Oils
 The Cholinergic Hypothesis, Essential Oils, and Alzheimer's Disease
 The Oxidative Stress Hypothesis, Essential Oils, and Alzheimer's Disease
 CONCLUDING REMARKS
 CONSENT FOR PUBLICATION
 CONFLICT OF INTERESTS
 ACKNOWLEDGEMENT
 REFERENCES
 Inspired by Nature: Modern Medicines Derived from Cannabis
 Bruno M. Fonseca*, Georgina Correia-da-Silva and Natércia Teixeira
 1. CANNABIS, CANNABINOIDS AND THEIR MEDICAL USE. 1.1. A Brief History of Cannabis Use in Medicine1.2. Cannabinoids
 2. MECHANISMS OF ACTION OF CANNABINOIDS
 2.1. Cannabinoid Receptors
 2.2. Cannabinoid Signalling Pathways
 2.3. The Endocannabinoid System
 3. CANNABIS AS MEDICINE
 3.1. Cannabinoid-Based Drugs Metabolism
 3.2. Cannabinoid Therapeutic Applications
 3.2.1. Antiemetic and Appetite Stimulant
 3.2.2. Cannabinoids and Food Intake
 3.2.3. Multiple Sclerosis
 3.2.4. Chronic Pain
 3.2.5. Epilepsy
 3.3. Main Limitations of Cannabinoids Use
 4. CONCLUDING REMARKS
 ABBREVIATIONS
 CONSENT FOR PUBLICATION
 CONFLICT OF INTEREST.