Frontiers in Modeling and Control of Breathing: Integration at Molecular, Cellular, and Systems Levels

Front Matter....Pages i-xix
Front Matter....Pages 1-1
Remembrance of “Oxford” Conferences Past....Pages 3-7
Workshop on Modeling in the 21 st Century....Pages 9-14
Front Matter....Pages 15-15
Central Respiratory Chemosensitivity: Cellular and Network Mechanisms....Pages 17-26
Chemoreception and Tonic Drive in the Retrotrapezoid Nucleus (RTN) Region of the Awake Rat....Pages 27-32
Chronic Intermittent Hypdxia Enhances Carotid Body Chemoreceptor Response to Low Oxygen....Pages 33-38
Neurotransmitter Release from the Rabbit Carotid Body: Differential Effects of Hypdxia on Substance P and Acetylcholine Release....Pages 39-43
Muscarinic Receptors Influence Catecholamine Release from the Cat Carotid Body During Hypdxia....Pages 45-48
Pharmacological and Immunochemical Evidence of the Dopamine D 3 Receptor in the Goat Carotid Body....Pages 49-53
The Excitatory Effect of Nitric Oxide on Carotid Body Chemoreception is Blocked by Oligomycin....Pages 55-60
Co 2 /Hco 3 - Modulates K + and Ca 2+ Currents in Glomus Cells of the Carotid Body....Pages 61-66
Inhibition or Lack of Nad(P)H Oxidase Subunits Do Not Alter the Normal Cytosolic Calcium, Sensory and Respiratory Response of Chemoreceptors....Pages 67-72
Peripheral and Central Chemosensitivity: Multiple Mechanisms, Multiple Sites?....Pages 73-80
Front Matter....Pages 81-81
Role of Brainstem Respiratory Neuron Types in Phase-Switching Produced by Afferent Vagal Stimulation....Pages 83-88
Modulation of the Central Respiratory Effects of 5-Ht by Vagal Afferents in Newborn Rat....Pages 89-93
Activation of Medullary Post-Inspiratory Related Neurons During Clonidine-Induced Central Apnea in Anesthetized Goats....Pages 95-99
Respiratory Control of Hypoglossal Motoneurons....Pages 101-106
Projections from Brainstem Gabaergic Neurons to the Phrenic Nucleus....Pages 107-111
Optical Recording of The Neuronal Activity in The Brainstem-Spinal Cord....Pages 113-118
Interfacing Computer Models with Real Neurons: Respiratory “Cyberneurons” Created with the Dynamic Clamp....Pages 119-124
Front Matter....Pages 125-125
Is the Vertebrate Respiratory Central Pattern Generator Conserved?....Pages 127-132
Front Matter....Pages 125-125
Unstable Breathing Rhythms and Quasiperiodicity in the Pre-Bötzinger Complex....Pages 133-138
Stationary Organotypic Culture of the Pre-Bötzinger Complex from the Newborn Rat....Pages 139-145
Respiratory Rhythm Generation: Prebötzinger Neuron Discharge Patterns and Persistent Sodium Current....Pages 147-152
Roles of the Bötzinger Complex in the Formation of Respiratory Rhythm....Pages 153-157
Models of Neuronal Bursting Behavior: Implications for In-Vivo Versus In-Vitro Respiratory Rhythmogenesis....Pages 159-164
Neurogenesis of the Respiratory Pattern: Insights from Computational Modeling....Pages 165-170
Reconfiguration of the Central Respiratory Network Under Normoxic and Hypdxic Conditions....Pages 171-178
How is the Respiratory Central Pattern Generator Configured and Reconfigured?....Pages 179-184
Front Matter....Pages 185-185
Respiratory Suppression Induced by Nicotine Withdrawal in the Neonatal Rat Brainstem....Pages 187-194
Effect of Dna Hypomethylation on Neural Control of Respiration: A Genetic Model....Pages 195-200
Respiratory Pattern and Hypdxic Ventilatory Response in Mice Functionally Lacking α 2a -Adrenergic Receptors....Pages 201-208
Do Genetic Factors Influence the Dejours Phenomenon?....Pages 209-214
Role of Nitric Oxide in Short-Term Potentiation and Long-Term Facilitation....Pages 215-219
Induction of Long-Term Modulation of the Exercise Ventilatory Response in Man....Pages 221-224
Metabolic Consequences of Hypdxic Conditioning in Lymnaea Stagnalis....Pages 225-229
The Lymnaea Respiratory System....Pages 231-236
Possible Mechanisms That May Determine the Set Point and Sensitivities of the Chemoreflexes....Pages 237-239
Modeling Respiratory Adaptations in Humans....Pages 241-245
Post-Hypdxic Frequency Decline Haracterized in the Rat Working Heart Brainstem Preparation....Pages 247-254
Model of Nonassociative Learning in Vagal-Pontine Modulation of the Respiratory Rhythm....Pages 255-260
Front Matter....Pages 185-185
Nmda Receptor Blockade Unmasks Novel Gating and Memory Mechanisms in Vagal Control of Respiratory Rhythm....Pages 261-266
Beyond Chemoreflex: Plasticity, Redundancy and Self-organization in Respiratory Control....Pages 267-272
Front Matter....Pages 273-273
Modeling the Ventilatory Response to Variations in End-Tidal PCO 2 in Patients Who Have Undergone Bilateral Carotid Body Resection....Pages 275-277
Cerebral Blood Flow Sensitivities to CO 2 with the Steady-State Method and Read’s Rebreathing Method....Pages 279-284
Modeling the Interaction Between Perfusion Pressure and CO 2 on Cerebral Blood Flow....Pages 285-290
Central Amino Acid Neurotransmitters, Ventilatory Output and Metabolism During Acute Hypdxia in Anesthetized Rats....Pages 291-296
Gene Regulation During Intermittent Hypdxia: Evidence for the Involvement of Reactive Oxygen Species....Pages 297-302
Response Surface Modeling of Drug Interactions on Cardiorespiratory Control....Pages 303-308
A Meta-Analysis of the Effect of Low-Dose Volatile Anaesthetics on the Ventilatory Response to Hypdxia....Pages 309-314
Simulation of the Respiratory Control System....Pages 315-320
Long-Haul Flights May Induce Respiratory Changes Similar to Ventilatory Acclimatisation to Altitude....Pages 321-323
Sustained Moderate Hyperoxia Augments the Acute Hypdxic Response in a Wake Goats....Pages 325-330
Respiratory Effects of Breathing High Oxygen During Incremental Exercise in Humans....Pages 331-336
Intra-Breath Profiles of Alveolar Gas Exchange and the Initial Limb-To-Lung Transit Delay During Exercise in Humans....Pages 337-342
Skeletal muscle chemoreflex in exercise Ventilatory control....Pages 343-348
Distention of Venous Structures in Muscles as a Controller of Respiration....Pages 349-356
Ventilatory and Circulatory Responses at the Onset of Rapid Changes in Posture....Pages 357-362
Cardiorespiratory Responses to Walking and Running at an Incremental Speed of Treadmill....Pages 363-368
The Breath Sound Check and Exercise at or about the Ventilatory Threshold....Pages 369-374
Improved 0 2 Transport and Utilization Capacity Following Intermittent Hypobaric Hypdxia in Rats....Pages 375-379
Front Matter....Pages 381-381
Intercept Shift in the Breathlessness/ Ventilation Relationship in Response to Progressive Increase in Workload....Pages 383-388
Ventilatory VS. Dyspneic Responses to Augmenting and Subsequently Declining CO 2 Stimulation in Humans....Pages 389-392
Hypdxic-Hypercapnic Interaction on Ventilatory Response and Respiratory Sensation in Females....Pages 393-397
Opioid Effect on Breathing Frequency and Thermogenesis in Mice Lacking Exon 2 of the µ-Opioid Receptor Gene....Pages 399-404
Modulation of Breathing Using Imperceptible Unloading....Pages 405-410
General Model for Patient-Ventilator Interactions....Pages 411-416
Phase Relations Between Rhythmical Forearm Movements and Breathing in Cerebellar Impaired Patients....Pages 417-424
Computational Modeling of Integration of Voluntarybehavioral and Automatic Mechanisms Forbreathing Control....Pages 425-430
The Control of Breathing at Rest....Pages 431-433
Central and Peripheral Chemoreflex Characteristics: Panic Disorder Patients VS. Healthy Volunteers....Pages 435-437
A Physiological and Psychological Model of Idiopathic Hyperventilation....Pages 439-444
Behavioral State Control and Airway Instability....Pages 445-450
Front Matter....Pages 451-451
Neural Drives and Breathing Stability....Pages 453-458
Variability of CO 2 -Sensitivity During Sleep....Pages 459-463
Dynamics of Heart Rate Control in Obstructive Sleep Apnea....Pages 465-470
Computational Model of the Effects of Breathing on Cardiac Function....Pages 471-476
Inspiratory Timing Differences and Regulation of Gria2 Gene Variation: A Candidate Gene Hypothesis....Pages 477-482
Explained and Unexplained Variability of CO 2 -Sensitivity in Humans....Pages 483-488
Comparison Between the Respiratory Inductance Plethysmography Signal Derivative and the Airflow Signal....Pages 489-494
Respiratory Instability and Variability: Why is Respiration Such a Mess?....Pages 495-500
Back Matter....Pages 501-508