Frontiers in Microbiology: From Antibiotics to AIDS

Front Matter....Pages I-XVIII
Front Matter....Pages 1-1
Introduction to Section IV: Tumor, Virus and Transplant Immunity....Pages 153-154
Mechanisms of Resistance to Viruses and Tumors, and the Development of Vaccines....Pages 155-164
Total Lymphoid Irradiation....Pages 165-172
Introduction to Section V: New Horizons in Virus Research....Pages 175-178
Perspectives in Disease Prevention by Vaccines....Pages 179-190
The Challenge of Chronic Virus Infections....Pages 191-206
Structure and Function of the Genome of HTLV-III and Related Viruses: Current Concepts on the Role of HTLV-III in the Pathogenesis of Aids....Pages 207-221
Introduction to Section I: Antibacterial, Antifungal and Antiviral Chemotherapy....Pages 5-6
β-Lactam Antibiotics as Carbonyl Donors of the Active-Site Serine β-Lacta-Mases, DD-Peptidases and LL-Peptidases....Pages 7-28
New Antifungal Agents: A Result of Target-Oriented Drug Design....Pages 29-46
Antiviral Chemotherapy: Design or Serendipity ?....Pages 47-61
Introduction to Section II: Gastrointestinal Microbiota and their Role in the Metabolism of Endogenous and Exogenous Substances....Pages 65-68
The Indigenous Gastrointestinal Microbiota....Pages 69-78
Metabolism of Endogenous Substances....Pages 79-88
Seeking Explanations for Pharmacological and Toxicological Phenomena in the Metabolic Reactions of the Intestinal Flora....Pages 89-104
Introduction to Section III: Humoral Factors in Immunity: Cytokines, Interferons and Interleukins....Pages 107-108
Mechanisms of Natural Resistance....Pages 109-124
Regulation of Cell Growth by Interferon and Tumor Necrosis Factor....Pages 125-136
The Role of Interleukin-1 in Mediating Host Defense Mechanisms....Pages 137-150
Front Matter....Pages 223-223
Synthesis and Activity of Some New Cephalosporins....Pages 227-228
Front Matter....Pages 223-223
Heterogeneity of Recombinant Murine Interferon-γ (MuIFN-γ)....Pages 255-259
Monoclonal Antibodies against Murine Interferon-γ and Their Use to Investigate the Role of Endogenous Interferon-γ in Vivo ....Pages 260-264
The Interrelationship Between Interleukin-1, Interferon-β and Hemopoietic Growth Factors....Pages 265-270
Studies on Gene Expression in Streptomyces Lividans....Pages 271-275
The Influence of Local Immune Suppression on Polyoma Virus-Induced Vascular Tumors....Pages 279-282
Induction of Transplantation Tolerance After Total Lymphoid Irradiation : Influence of Thymus Transplantation or Blood Transfusions....Pages 283-286
Mechanism of Antiviral Action of 5-Substituted 2′-Deoxyuridines: ( E )-5-(2-Iodovinyl)-2′-Deoxyuridine (IVDU) as Compared to its Carbocyclic Analogue (C-IVDU)....Pages 289-292
Therapeutic Implications of the Unusually Long Half-Life of ( E )-5-(2-BRO-Movinyl)Uracil (BVUra) in Vivo....Pages 293-296
S-Adenosyl-L-Homocysteine Hydrolase as Target Enzyme for Antiviral Agents: Studies with Adenosine Kinase-Deficient Rat Cells....Pages 297-299
Antiviral Activity of ( S )-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine [( S )-HPMPA]....Pages 300-304
Selective Inhibitory Effects of ( S )-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine and 2′-Nor-cGMP on the Replication of Adenovirus In Vitro ....Pages 305-307
Incorporation of Nucleoside Analogues into Oligonucleotides....Pages 229-230
2′–5′-Oligoadenylates (2–5A) As Mediators of Interferon Action. Synthesis and Biological Activity of New 2–5A Analogues....Pages 231-233
Cloning and Expression of an rRNA Methylase Gene in Streptomyces Venezuelae Phage VWB....Pages 237-238
Coprostanic Acids and a C 29 -Dicarboxylic Bile Acid in Peroxisomal Diseases....Pages 239-240
Bile Acid Desulfation by the Gut Microflora....Pages 241-243
Steroid Desulfation by the Gut Microflora....Pages 244-246
Biohydrogenation of Fatty Acids by Intestinal Bacteria....Pages 247-248
Classification of the Genus Eubacterium ....Pages 249-250
Isolation and Characteristics of Clostridium HDCA-1, Nova Species....Pages 251-252
Front Matter....Pages 223-223
In Search of Antiviral Compounds Against the AIDS Virus....Pages 308-313