Frontiers in Arterial Chemoreception

Front Matter....Pages i-xiii
A Tribute to Fernando De Castro on the Centennial of His Birth....Pages 1-11
Prolegomena....Pages 13-38
Daniel J. C. Cunningham....Pages 39-43
Re-Examination of the Carotid Body Ultrastructure with Special Attention to Intercellular Membrane Appositions....Pages 45-50
Two Morphological Types of Chemoreceptor Afferents Innervate the Rabbit Carotid Body....Pages 51-54
Mitochondrial Division, Blood Vessel Dilation, and Large Intercellular Space Expansion of Goat Carotid Body During Hypoxia....Pages 55-58
PO 2 Affinities, Heme Proteins, and Reactive Oxygen Intermediates Involved in Intracellular Signal Cascades for Sensing Oxygen....Pages 59-64
Photochemical Action Spectra, Not Absorption Spectra, Allow Identification of the Oxygen Sensor in the Carotid Body....Pages 65-71
Mechanisms of Carotid Chemoreceptor Resetting after Birth....Pages 73-77
Carotid Chemosensory Response to Caffeine in Developing Cats....Pages 79-82
Role of Potassium Channels in Hypoxic Chemoreception in Rat Carotid Body Type-I Cells....Pages 83-87
Is Cytochrome P-450 Involved in Hypoxic Inhibition of K + Currents in Rat Type I Carotid Body Cells?....Pages 89-92
Cyclic Nucleotide Analogs do not Interfere with Hypoxic Inhibition of K + Currents in Isolated Rat Type I Carotid Body Cells....Pages 93-96
Modulation of Voltage-Gated Ca 2+ Channels by O 2 Tension....Pages 97-103
Ca 2+ Channel Currents in Type I Carotid Body Cells from Normoxic and Chronically Hypoxic Rats....Pages 105-108
Metabolic Inhibitors Affect the Conductance of Low Voltage-Activated Calcium Channels in Brain Capillary Endothelial Cells....Pages 109-113
Transmembrane Currents in Capillary Endothelial Cells are Modulated by External Mg 2+ Ions....Pages 115-118
Evaluation of Gene Expression in the Rat Carotid Body Using the Differential Display Technique....Pages 119-125
Induction of Immediate Early Response Genes by Hypoxia....Pages 127-134
Regulation of Ionic Conductances and Gene Expression by Hypoxia in an Oxygen Sensitive Cell Line....Pages 135-142
Regulation of Tyrosine Hydroxylase mRNA Stability by Oxygen in PC12 Cells....Pages 143-150
Effects of Hypoxia on the Intercellular Channel Activity of Cultured Glomus Cells....Pages 151-158
Reflections on the Carotid Nerve Sensory Discharge and Coupling Between Glomus Cells....Pages 159-167
Generation of Interspike Intervals of Rat Carotid Body Chemoreceptors....Pages 169-174
The Coupling Between Intracellular pH, Ion Transport, and Chemosensory Discharge....Pages 175-180
Depolarization is a Critical Event in Hypoxia-Induced Glomus Cell Secretion....Pages 181-187
Co-Cultures of Rat Petrosal Neurons and Carotid Body Type 1 Cells....Pages 189-193
Responses of Cat Petrosal Ganglion Neurons are Modified by the Presence of Carotid Body Cells in Tissue Cultures....Pages 195-201
Modifications of Carotid Body CO 2 Chemosensitivity In Vitro ....Pages 203-210
Intracellular Acidosis Potentiates Carotid Chemoreceptor Responses to Hypoxia in the Absence of CO 2 -HCO 3 − ....Pages 211-216
Central pH Chemosensitivity in the Newborn Opossum Monodelphis Domestica ....Pages 217-220
Simultaneous Measurements of Cytosolic Calcium Ion and pH in Cultured Superior Cervical Ganglion Cells of Rat....Pages 221-226
Release of Acetylcholine from the In Vitro Cat Carotid Body....Pages 227-232
Release of Acetylcholine from Cultured Cat and Pig Glomus Cells....Pages 233-237
Acetylcholine Elevates Intracellular Ca 2+ Via Muscarinic and Nicotinic Receptors in Rat Carotid Body Type I Cells....Pages 239-244
The Presynaptic Component of a Cholinergic Mechanism in the Carotid Body Chemotransduction of Hypoxia in the Cat....Pages 245-252
Localization of Nicotinic Acetylcholine Receptors in Cat Carotid Body and Petrosal Ganglion....Pages 253-256
Effect of Acetylcholine on Intracellular Calcium of Carotid Body Cells of Adult Cats....Pages 257-260
Dopamine Efflux from the Carotid Body During Hypoxic Stimulation....Pages 261-266
Catecholamine Secretion from Glomus Cells is Dependent on Extracellular Bicarbonate....Pages 267-273
Chronic Hypoxia Enhances Expression of Catecholamine Biosynthesizing Enzymes in Rat Carotid Body....Pages 275-277
Intracellular Ca 2+ Deposits and Catecholamine Secretion by Chemoreceptor Cells of the Rabbit Carotid Body....Pages 279-284
Dopamine D 2 Receptor mRNA Isoforms Expression in the Carotid Body and Petrosal Ganglion of Developing Rabbits....Pages 285-289
Domperidone as a Tool to Assess the Role of Dopamine within Carotid Body Chemoreception....Pages 291-297
Adenosine Increases the cAMP Content of the Rat Carotid Body In Vitro ....Pages 299-303
Endothelin Modulates Chemoreceptor Cell Function in Mammalian Carotid Body....Pages 305-311
Expression and Localization of Enkephalin, Substance P, and Substance P Receptor Genes in the Rat Carotid Body....Pages 313-318
Neuropeptide Processing Enzymes of the Carotid Body....Pages 319-323
Coexistence of Neuropeptides in the Amphibian Carotid Labyrinth....Pages 325-328
Secretoneurin....Pages 329-333
Carbon Monoxide Excretion, Not Oxygen Secretion?....Pages 335-339
Carbon Monoxide and Carotid Body Chemoreception....Pages 341-344
Regulation of Neuronal Nitric Oxide Synthase Gene Expression by Hypoxia....Pages 345-348
Coherence of Chemosensory Discharges in Cats’ Carotid Nerves....Pages 349-356
Carotid Chemoreflex....Pages 357-364
Afferent Input from Peripheral Chemoreceptors in Response to Hypoxia and Amino Acid Neurotransmitter Generation in the Medulla....Pages 365-369
Augmented Ventilatory Response to Sustained Normocapnic Hypoxia Following 100% O 2 Breathing in Humans....Pages 371-375
Role of Carotid Bodies in the Guinea-Pig....Pages 377-381
Effects of Continuous Intracarotid Infusion of Dopamine During Long-Term Hypoxia in Awake Goats....Pages 383-386
The Role of Carotid Body CO 2 During Ventilatory Acclimatization to Hypoxia in the Goat....Pages 387-390
Dynamic Sensitivity of Carotid Chemoreceptors to CO 2 in the Newborn Lamb....Pages 391-396
A Phospholipase C Inhibitor Impedes the Hypoxic Ventilatory Response in the Cat....Pages 397-403
Modelling the Peripheral Chemosensory Drive of Ventilation on Basis of Homogenous Sensory Units....Pages 405-410
Functional Activation of Cerebral Glucose Uptake after Carotid Body Stimulation....Pages 411-420
Prolonged Hemodynamic Effects of Intermittent, Brief Chemoreceptor Stimulation in Humans....Pages 421-429
Interaction Between the Bradycardic Responses to Upper Airway Negative Pressure and Carotid Chemoreceptor Stimulation in the Anaesthetised Rabbit....Pages 431-437
Chemoreceptors in Autonomic Responses to Hypoxia in Conscious Rats....Pages 439-442
The Effect of Sympathetic Nerve Stimulation on Ventilation and Upper Airway Resistance in the Anaesthetized Rat....Pages 443-447
Ventilatory and Upper Airway Muscle Responses to Upper Airway CO 2 in Anaesthetized Neonatal Guinea-Pigs....Pages 449-452
Neurogenic Inflammation....Pages 453-462
Effects of Hypercapnia on Steady State, Phenylephrine-Induced Tension in Isolated Rings of Rat Pulmonary Artery....Pages 463-469
Back Matter....Pages 471-480