From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System

Front Matter....Pages i-xxviii
Front Matter....Pages 1-1
Frontiers of Cancer Research: The Metastasis Challenge....Pages 3-10
Vascular Endothelial Growth Factor: Basic Biology and Clinical Applications....Pages 11-21
Proliferation and Cancer Metastasis from the Clinical Point of View....Pages 23-27
Gastrointestinal Cancer and the Lymphatic System: Patterns of Micrometastasis and Lymphatic Mapping with Clinical Outcome....Pages 29-43
Redefined Lymphatic Anatomy of the Breast with Clinical Implications....Pages 45-55
Should Axillary Lymph Node Dissection be Done for Breast Cancer?....Pages 57-66
Front Matter....Pages 67-67
Overview of Tumor Cells and the Microenvironment....Pages 69-73
Front Matter....Pages 75-75
Heme/Lymphvasculogenesis, Hem/Lymphangiogenesis, Hem/Lymphangiotumorigenesis, and Tumor Hem/Lymphangiogenesis: Need for a Terminology Adjustment....Pages 77-92
Tumor Lymphangiogenesis: What We Know and Don\'t Know....Pages 93-104
Front Matter....Pages 105-105
Molecular Imaging of Cancer: Receptors, Angiogenesis, and Gene Expression....Pages 107-114
MRI and Ultrasound Imaging of Lymph Nodes....Pages 115-122
Molecular Imaging of the Sentinel Lymph Node via Lymphoseek....Pages 123-133
Lymphatic Disorders in Patients with Cancer....Pages 135-157
3D-CT Lymphography for Mapping Metastatic Breast Sentinel Node and Axillary Nodes....Pages 159-168
Molecular Imaging of Neuroendocrine Cancer by Fusion SPET/CT....Pages 169-175
Functional Molecular Imaging of Prostate Cancer Lymph Node Metastases: Adenovirus-Mediated Lymph Node Detection....Pages 177-188
Front Matter....Pages 189-189
Therapeutic Targeting of the Lymphovascular System in Cancer: Promise and Challenge....Pages 191-199
Comparison of Liposomal and Aqueous Blue Dye in Visualization of Lymph Nodes Prior to Lymphadenectomy....Pages 201-208
Front Matter....Pages 209-209
The Role of Lymphangiogenesis in Regional Lymph Node Metastasis: Animal Models....Pages 211-226
Sentinel Lymph Node Chemokine Microenvironment Modulated by Melanoma Metastasis....Pages 227-235
Front Matter....Pages 209-209
Circulating and Disseminated Tumor Cells from Solid Tumors—Research and Clinical Aspects....Pages 237-241
Head and Neck Cancer: An Example for the Role of Chemokine Receptors in Tumor Progression and Metastasis....Pages 243-254
Tumor and Lymph Node Lymphangiogenesis....Pages 255-261
T reg , Chemokines, and Other Small Molecules: Role in Metastasis and Its Prevention....Pages 263-279
Front Matter....Pages 281-281
Molecular Targeting of Lymphangiogenesis and Tumor Metastasis....Pages 283-295
Combined Targeting of EGFR and Angiogenesis in Aerodigestive Carcinomas....Pages 297-307
Targeting Signaling Pathways in Cancer Therapy....Pages 309-326
Front Matter....Pages 327-327
Micrometastasis of Melanoma to Sentinel Lymph Nodes....Pages 329-337
Sentinel Lymph Node Micrometastases in Breast Cancer: Prognostic Relevance and Therapeutic Implications....Pages 339-345
Micrometastasis of Genitourinary Cancer to Sentinel Lymph Nodes....Pages 347-359
Sentinel Lymph Node Mapping in Colorectal Cancer....Pages 361-379
Application of Cancer Biology in Cancer Staging and Predicting Clinical Outcome....Pages 381-388
Front Matter....Pages 389-389
Role of Lymph Nodes in Immunotherapy of Malignant Tumors....Pages 391-400
Tumor-Related Immune Modulation of the Regional Lymph Nodes....Pages 401-406
Reversal of Immune Suppression in Sentinel Lymph Nodes....Pages 407-423
Vaccine-Primed Lymph Node Cells in the Adoptive Immunotherapy of Cancer: Presence of Host Immune Suppression Induced by Established Cancer....Pages 425-432
Front Matter....Pages 433-433
Cancer Stem Cells in Metastatic Melanoma....Pages 435-441
Implications of Cancer Stem Cells for Tumor Metastasis....Pages 443-453
Prostate Cancer Stem Cells and Their Involvement in Metastasis....Pages 455-461
Front Matter....Pages 463-463
Estrogen Receptor-Positive Breast Cancer: Traditional Prognostics, Molecular Pathology: A New Breast Cancer Taxonomy and 21st Century Personalized Prognostic and Predictive Assays....Pages 465-495
Front Matter....Pages 463-463
Molecular Signatures in Melanoma Progression....Pages 497-509
Front Matter....Pages 511-511
Targeted Therapy for Breast Cancer: A Focus on HER2/neu and Antiangiogenic Therapy....Pages 513-521
Advances in the Treatment of Colorectal Cancer: Targeting Receptors of Disease....Pages 523-532
Developments in the Management of Genitourinary Malignancies: Prostate Cancer and Renal Cell Carcinoma....Pages 533-544
Advances in the Treatment of Lung Cancer....Pages 545-552
Front Matter....Pages 553-553
Pegylated Interferons in the Adjuvant Treatment of Melanoma....Pages 555-564
Sorafenib, a Multikinase Inhibitor: Results from Clinical Trials in Melanoma Patients....Pages 565-574
Targeting Immunological Synapse: New Horizons in Immunotherapy for Cancer....Pages 575-590
Cutaneous Metastases of Melanoma: New Treatment Options....Pages 591-598
Neoadjuvant Approaches in Melanoma....Pages 599-605
Implications of Chemo/Biochemotherapy in the Treatment of Metastatic Melanoma....Pages 607-609
Front Matter....Pages 611-611
Future Perspectives for Cancer Metastasis: Unanswered Questions and Unquestioned Answers....Pages 613-616
Back Matter....Pages 617-637