Freeze Drying of Pharmaceutical Products

1. The Freeze-Drying of Pharmaceutical Products: Introduction and Basic Concepts
[Davide Fissore, Roberto Pisano, and Antonello Barresi]
2. Formulation Design and Optimization Using Molecular Dynamics
[Roberto Pisano and Andrea Arsiccio]
3. Established and Novel Excipients for Freeze-Drying of Proteins
[Ivonne Seifert and Wolfgang Friess]
4. Infrared Imaging and Multivariate Image Analysis (MIA): A New PAT for Freeze-Drying Monitoring and Control
[Domenico Colucci, José Manuel Prats-Montalbán, Alberto Ferrer, and Davide Fissore]
5. Through-Vial Impedance Spectroscopy (TVIS): A New Method for Determining the Ice Nucleation Temperature and the Solidification End Point
[Geoff Smith and Yowwares Jeeraruangrattana]
6. Innovations in Freeze-Drying Control and In-Line Optimization
[Antonello Barresi, Roberto Pisano, and Davide Fissore]
7. Use of a Micro Freeze-Dryer for Developing a Freeze-Drying Process
[Taylor N. Thompson and Davide Fissore]
8. Continuous Manufacturing in Lyophilization of Pharmaceuticals: Drawbacks of Batch Processing, Current Status, and Perspectives
[Roberto Pisano, Luigi C. Capozzi, and Jos A.W.M. Corver]
9. Use of CFD for the Design and Optimization of Freeze-Dryers
[Antonello Barresi]