Free Radicals: from Basic Science to Medicine

Front Matter....Pages I-X
Front Matter....Pages 1-1
Trevor Slater, Free Radical Redox Chemistry and Antioxidants: from NAD + and Vitamin C TO CCl 4 and Vitamin E, to Thiols, Myoglobin and Vitamins A and D....Pages 2-17
Regulation of Gene Expression in Adaptation to Oxidative Stress....Pages 18-30
Radiation-Induced Free Radical Reactions....Pages 31-37
Nitric Oxide and Related Radicals....Pages 38-46
Mechanisms of Oxidative Cell Damage....Pages 47-64
Lipid Peroxidation. An Overview....Pages 65-79
Lipid Peroxidation In Dividing Cells....Pages 80-88
Formation and Metabolism of the Lipid Peroxidation Product 4-Hydroxynonenal in Liver and Small Intestine....Pages 89-101
DNA Damage By Reactive Oxygen Species. The Role Of Metals....Pages 102-112
Inflammation and a Mechanism of Hydrogen Peroxide Cytotoxicity....Pages 113-122
Front Matter....Pages 123-123
Free Radical Theory Of Aging....Pages 124-143
Oxidative Stress State in Aging and Longevity Mechanisms....Pages 144-156
Maillard Reaction and Oxidative Stress are Interrelated Stochastic Mechanisms of Aging....Pages 157-168
Glycoxidation: A Non-Enzymatic Mechanism Of Protein Ageing....Pages 169-174
Marker Or Mechanism: Possible Pro-Oxidant Reactions Of Radicaldamaged Proteins In Aging and Atherosclerosis, An Age-Related Disease....Pages 175-184
Front Matter....Pages 185-186
Carcinogenesis and Free Radicals....Pages 187-198
Derangements of Cellular Metabolism in The Pre-Malignant Syndrome....Pages 199-205
Molecular Mechanisms Of Oxidant Carcinogenesis....Pages 206-217
The Involvement of Oxy-Radicals in Cancer Cell Killing and Growth....Pages 218-225
Free Radicals and Active States of Oxygen in Human Cancer Due to Environmental Pollutants: Public Health Optimism and Scientific Skepticism....Pages 226-240
Front Matter....Pages 241-241
Hepatotoxicity Of Experimental Hemochromatosis....Pages 242-254
Role of Inducible Cytochrome P450 in the Liver Toxicity of Polyhalogenated Aromatic Compounds....Pages 255-261
CBrCl3-Toxicity In Isolated Rat Hepatocytes: Survey On Reasonable Cytotoxic Mechanisms....Pages 262-273
Evidence for a Possible Role of Lipid Peroxidation in Experimental Liver Fibrosis....Pages 274-286
Ethanol-Inducible Cytochrome P450 2E1. Regulation, Radical Formation and Toxicological Importance.....Pages 287-301
Free Radical-Induced Impairment of Liver Glycosylation Processes in Ethanol Intoxication....Pages 302-309
Oxidative Damage and Human Alcoholic Liver Diseases. Experimental and Clinical Evidence....Pages 310-322
Oxidised Low Density Lipoproteins....Pages 323-339
Protein Peroxides: Formation by Superoxide-Generating Systems and During Oxidation of Low Density Lipoprotein....Pages 340-348
An in Vitro Approach to the Study of Inflammatory Reactions in Atherosclerosis....Pages 349-363
Front Matter....Pages 364-364
Antioxidant Defenses In Eukariotic Cells: An Overview....Pages 365-373
Electron Paramagnetic Resonance Studies of Flavonoid Compounds....Pages 374-387
Antioxidant Mechanisms of Vitamin E and β-Carotene....Pages 388-399
A Nuclear Pool of Glutathione in Hepatocytes....Pages 400-411
Phospholipid Hydroperoxide Glutathione Peroxidase Is The Major Selenoperoxidase In Nuclei and Mitochondria Of Rat Testis....Pages 412-418
Medical Applications of Antioxidants: An Update of Current Problems....Pages 419-423
Free Radicals and Antioxidants in Muscular and Neurological Diseases and Disorders....Pages 425-437
Pharmaceutical Intervention for the Prevention of Post-Ischemic Reperfusion Injury....Pages 438-457
Metal-Catalyzed Free Radical Injuries In Childhood: Disorders and Pharmaceutical Intervention....Pages 458-478
Effect of Vitamin E and Other Antioxidants on the Oxidation Resistance of Human Low Density Lipoproteins....Pages 479-488
Front Matter....Pages 364-364
Approaches To The Therapy Of Glutathione Deficiency....Pages 489-505
Utilization Of Oral Glutathione....Pages 506-523
Back Matter....Pages 525-529