Free Radicals, Lipoproteins, and Membrane Lipids

Front Matter....Pages i-ix
Front Matter....Pages xi-xi
Radical Mechanisms in Fatty Acid and Lipid Peroxidation....Pages 1-16
Lipid Peroxidation by Phagocytes....Pages 17-21
Triggering and Regulation of the Free Radical Production by Phagocytes....Pages 23-44
Two Structurally Unrelated PAF Antagonists, BN 52021 and BN 52111, Partially Inhibit TNF-Induced Superoxide Release by Human Neutrophils....Pages 45-53
Membrane Glycoproteins in Superoxide Release from Neutrophils....Pages 55-63
Free Radical Production by the Mitochondrion....Pages 65-71
Hemoglobin as a Promoter of Central Nervous System Damage....Pages 73-79
Role of Xanthine Oxidase and Granulocytes in Ischemia/Reperfusion Injury....Pages 81-88
Evidence for Free Radical Generation in Vivo during Cardiac Ischemia and Reperfusion....Pages 89-97
Superoxide Generation by Clastogenic Factors....Pages 99-104
Front Matter....Pages N1-N1
Degradation of Membrane Phospholipids by a Direct Nucleophilic Action of Superoxide Anion....Pages 105-113
Mechanisms of Formation of Oxysterols: A General Survey....Pages 115-132
Role of Oxygen and of Superoxide Radical in the Mechanisms of Monoelectronic Activation of Various Xenobiotics : A Radiolysis Study....Pages 133-142
Front Matter....Pages N3-N3
Methods of Measuring Lipid Peroxidation in Biological Systems: An Overview....Pages 143-152
Measurement of Superoxide and Superoxide Dismutase by Electron Spin Resonance and Chemiluminescence Assay....Pages 153-162
Pentane Measurement, an Index of in Vivo Lipoperoxidation: Applications and Limits of the Method....Pages 163-169
Front Matter....Pages N5-N5
Action of the Aldehydes Derived from Lipid Peroxidation on Isolated Liver Plasmamembranes....Pages 171-181
Carbon Tetrachloride-Induced Oxidative Stress at the Level of Liver Golgi Apparatus: Effect on Lipoprotein Secretion....Pages 183-191
Front Matter....Pages N7-N7
Role of Low Density Lipoprotein Oxidation in Foam Cell Formation....Pages 193-202
In Vitro Oxidation of Low Density Lipoproteins....Pages 203-213
Front Matter....Pages N7-N7
Paradoxical Effects of Vitamin E: Oxidized Lipoproteins, Prostanoids and the Pathogenesis of Atherosclerosis....Pages 215-237
The Role of Oxidative Metabolism and Antioxidants in Low-Density Lipoprotein Structure and Metabolism....Pages 239-247
A New Model System for Studying the Cytotoxicity of Peroxidized Lipoproteins in Cultured Cells....Pages 249-256
Front Matter....Pages N9-N9
Molecular Mechanisms of Oxidative Cell Damage....Pages 257-267
Decompartmentalised Iron, Microbleeding and Membrane Oxidation....Pages 269-278
Mutagenic Effects of Oxidized Lipids....Pages 279-289
Biological Effects of Oxysterols....Pages 291-300
Mechanisms of Hydroperoxide-Induced Broncho- and Vasoconstriction in the Perfused Rat Lung....Pages 301-307
Pathophysiological Relevance of Free Radicals to the Ethanol-Induced Disorders in Membrane Lipids....Pages 309-315
Lipid Peroxidation in Experimentally Produced Liver Injury, Liver Tumors and in Liver Regeneration....Pages 317-326
Lipid Peroxidation and Cellular Functions: in Vitro Models and Relation to in Vivo Observations....Pages 327-342
Biochemical Mechanisms of Oxidant-Induced Cell Injury....Pages 343-358
Front Matter....Pages N11-N11
Cytochrome P-450 and Vitamin E Free Radical Reductase: Formation of and Protection Against Free Radicals....Pages 359-370
Free Radical Formation and Antioxidant Protection in Extracellular Fluids....Pages 371-379
Quinone Redox Cycling and the Protective Effect of DT Diaphorase....Pages 381-387
Vitamin E — Vitamin C Synergestic Effect Towards Peroxyl Radicals: Influence of Dehydro-Ascorbic Acid....Pages 389-397
Back Matter....Pages 399-409