Food Factors for Cancer Prevention

Front Matter....Pages II-XV
Front Matter....Pages 1-1
Diet and Cancer: Epidemiological Approaches....Pages 3-8
Mechanisms of Chronic Disease Prevention....Pages 9-13
Epidemiology of Vegetables and Fruits in Cancer Prevention....Pages 14-20
Antimutagenesis and Cancer Prevention....Pages 21-25
Multiple Mechanisms of Cancer Prevention by Phytochemicals: Interaction Between Cellular Proliferation and Endogenous Mutagens....Pages 26-29
Diet and Cancer Prevention in the United States....Pages 30-35
Biochemoprevention: A New Concept for Cancer Control....Pages 36-38
Biochemical and Physiological Importance of Plant Polyphenols....Pages 39-46
Studies on Functional Foods in Japan: State of the Art....Pages 47-51
Front Matter....Pages 53-53
Free Radicals, Antioxidants, and Cancer....Pages 55-57
Increased 8-Hydroxyguanine Repair Activity in Animal Livers and Human Leukocytes Induced by Oxidative Stress: Effects of Diet, Physical Exercise, and Cigarette Smoking....Pages 58-62
Effects of Aging and Vitamin A Deficiency on DNA Damage....Pages 63-66
Use of Mouse JB6 Cells to Identify Molecular Targets and Novel Agents for Prevention of Carcinogenesis....Pages 67-76
Tumor Progression Accelerated by Oxygen Species and Its Chemoprevention....Pages 77-81
Prevention of Chemically Induced Rat Carcinogenesis by Antioxidants: Focus on HTHQ....Pages 82-87
Development of Medium-Term Bioassays for Detection of Chemopreventive Agents....Pages 88-91
Preventive Effects of Various Antioxidants on Endogenous Liver Carcinogenesis in Rats Fed a Choline-Deficient, L-Amino Acid-Defined Diet....Pages 92-97
Protective Role of Dietary Factors in Carcinogenesis of Digestive Organs....Pages 98-102
Front Matter....Pages 103-103
Epidemiological Evidence for Prevention of Cancer and Cardiovascular Disease by Drinking Green Tea....Pages 105-108
Tea Components and Cancer Prevention....Pages 109-112
Front Matter....Pages 103-103
Mechanistic Considerations of the Inhibition of Carcinogenesis by Tea....Pages 113-117
Inhibitory Effects and Toxicity of Green Tea Components for the Prevention of Gastrointestinal Carcinogenesis....Pages 118-121
Anticarcinogenesis of Tea Polyphenols....Pages 122-126
Mechanisms of (−)-Epigallocatechin Gallate and Green Tea in Inhibition of Carcinogenesis....Pages 127-129
Tea as Antioxidant in Prevention of Lung Cancer....Pages 130-133
Inhibitory Effects of Green Tea Infusion on In Vitro Invasion and In Vivo Metastasis of Mouse Lung Carcinoma Cells....Pages 134-137
Antitumor-Promoting Effects of Tea Aqueous Nondialysates in Mouse Epidermal JB6 Cells....Pages 138-141
Inhibitory Effect of Tea Extracts on the Formation of Heterocyclic Amines During Cooking of Hamburger....Pages 142-146
Prophylactic Functions of Antioxidant Tea Polyphenols....Pages 147-151
Antioxidative Activity Against Superoxide of Anticarcinogenic Tea-Leaf Catechins: Measurement by the Cypridina Chemiluminescence Method....Pages 152-155
Front Matter....Pages 157-157
Stimulation of Leukocytes by Vegetable and Fruit Juices....Pages 159-161
Formation of Thioproline, Effective as a Nitrite-Trapping Agent in the Human Body, in Various Cooked Foods....Pages 162-165
Antimutagen Formation and Nitrite Scavenging by Unprocessed or Processed Fruit and Vegetable Fibers....Pages 166-169
Anticancer Functions of Nondialyzable Extracts of Vegetables and Fruits....Pages 170-173
Spinach Induces the Differentiation of Human Leukemia Cells....Pages 174-177
Effects of Apple Pectin on Fecal Enzyme Activities and Prostaglandin E 2 Levels in Azoxymethane-induced Rat Colon Carcinogenesis....Pages 178-181
Some Phytochemicals and Related Compounds in Vegetables as Potent Inhibitors of Human DNA Topoisomerase II....Pages 182-187
Anti-tumor Promoters from Edible Thai Plants: Isolation, Cancer Preventive Potential, and Action Mechanisms....Pages 188-193
Chemoprevention of Oral and Colon Carcinogenesis by Natural Compounds Protocatechuic Acid, 1′-Acetoxychavicol Acetate, S -Methyl Methane Thiosulfonate, and Hesperidin from Vegetables and Fruits....Pages 194-199
Enhancement by Indole-3-Carbinol of Liver and Thyroid Gland Neoplastic Development in a Rat Medium-Term Multiorgan Carcinogenesis Model....Pages 200-203
Front Matter....Pages 157-157
Distribution of Carotenoids in Fruits and Vegetables as a Criterion for the Selection of Appropriate Chemopreventive Agents....Pages 204-208
The Tomato Carotenoid Lycopene and Cancer....Pages 209-212
Front Matter....Pages 213-213
Organoselenium and Organosulfur Phytochemicals from Genus Allium Plants (Onion, Garlic): Relevance for Cancer Protection....Pages 215-221
The Role of Flavonoids and Garlic in Cancer Prevention....Pages 222-225
Garlic Reduces Plasma Cholesterol in Hypercholesterolemic Men Maintaining Habitual Diets....Pages 226-230
Inhibition Site of Methylallyl Trisulfide: A Volatile Oil Component of Garlic, in the Platelet Arachidonic Acid Cascade....Pages 231-234
Antitumor-Promoting Activities of Ginsenoside Rg 1 and Panax notoginseng ....Pages 235-239
Preventive Effects of Panax ginseng C. A. Meyer on Various Human Cancers....Pages 240-244
Sesamin, a Multifunctional Factor for Prevention of Various Disorders Including Carcinogenesis....Pages 245-248
Antioxidant and Antitumorigenic Properties of Curcumin....Pages 249-252
Antitumorigenic Activity of Rosemary....Pages 253-256
Effects of Capsaicin, a Major Pungent Principle in Hot Red Pepper, on Chemically Induced Carcinogenesis and Mutagenesis....Pages 257-261
Front Matter....Pages 263-263
Antitumor Promoters from Plants Used as Condiments or Garnishes....Pages 265-269
Cancer Chemoprevention with Everyday Food, Traditional Japanese Food, and Traditional Folk Medicines....Pages 270-275
Bioactive Phenolic Compounds for Cancer Prevention from Herbal Medicines....Pages 276-279
Structure-Activity Relationship of Antioxidant and Antitumor Polyphenols....Pages 280-285
Abrus ( A. precatorius L.) Leaf Extract as a Novel Antitumor Agent....Pages 286-289
Front Matter....Pages 291-291
Antioxidative Defense System and Free Radical Scavenging Potentials of Cereals....Pages 293-298
Natural Antioxidants from Oilseeds....Pages 299-303
A Strong Antioxidant Found in Young Green Barley Leaves....Pages 304-308
Front Matter....Pages 291-291
Antioxidative and Antigenotoxic Properties of Flavonoids from Beans ( Phaseolus vulgaris L.)....Pages 309-312
Photon Emission by Natural Radical Scavengers in the Presence of Active Oxygen Species....Pages 313-317
Inhibition of Lipid Peroxidation and Radical Scavenging Effect of Anthocyanin Pigments Isolated from the Seeds of Phaseolus vulgaris L.....Pages 318-322
Triterpene Saponins from Vigna unguiculata, Phaseolus vulgaris, Phaseolus coccineus, Canavalia gladiata , and Lupinus polyphyllus x arboreus : Their Structures, Antihepatotoxic Activities, and Antioxidative Inactivity....Pages 323-327
Front Matter....Pages 329-329
Antitumor Peptidoglycan with New Carbohydrate Structure from Squid Ink....Pages 331-336
Dietary Marine Algae and Their Antitumor Effects....Pages 337-341
Antimutagenic, Antiinflammatory, and Potential Anticancer Substances from Marine Algae....Pages 342-347
Front Matter....Pages 349-349
Effects of Miso in Reducing Risk of Liver and Gastric Tumors in Experimental Animals....Pages 351-354
Food Factors from Fermented Foods: Isolation of Monascin, Ankaflavin, and Kojic Acid as Lipoxygenase Inhibitors from Beni-Koji and Koji....Pages 355-358
Superoxide Radical Scavenging Activities of Wines, and Antioxidative Properties of Fractions Recovered from Merlot Wine Pomace....Pages 359-364
Conjugated Linoleic Acid: An Anticarcinogenic Nutrient....Pages 365-366
Intestinal Flora and Cancer Control: Inhibitory Effect of Oral Administration of Lactobacillus casei in a Model of Hepatic Metastasis of Rat....Pages 367-370
Prophylactic Effect of a Lactobacillus casei Preparation on the Recurrence of Bladder Cancer....Pages 371-374
Free Radical-Scavenging Effect of a Designed Antioxidant Drink: An Electron Spin Resonance Study....Pages 375-379
Front Matter....Pages 381-381
Dynamics of Trace Elements and Metal-Dependent Enzymes in Stomach Cancer Patients....Pages 383-388
Stomach Cancer and Mineral Intake....Pages 389-395
Chemopreventive Effects of Magnesium Hydroxide on Colon Carcinogenesis....Pages 396-400
Dietary Calcium and Vitamin D as Inhibitors of Colon and Breast Carcinogenesis....Pages 401-407
Front Matter....Pages 409-409
A New Approach to the Treatment of Atopic Dermatitis: Antioxidant Vitamins and Atopic Dermatitis....Pages 411-414
Effect of Dietary Paraquat on a Rat Mutant Unable to Synthesize Vitamin C....Pages 415-417
Front Matter....Pages 409-409
Role of Supplemental Ascorbate on Regulation of Growth in Cultured Cells....Pages 418-420
Physiological Role of Ascorbic Acid in Xenobiotic Metabolism and Protection Against Oxidative Stress....Pages 421-423
Biological Antioxidants Under Oxidative Stress....Pages 424-427
Front Matter....Pages 429-429
Vitamin E and Cancer Prevention: Methodological Aspects of Human Studies....Pages 431-435
Inhibitory Effect of Vitamin E on Cellular Events Related to Lung Tumorigenesis in Mice....Pages 436-439
Prevention of Breast Cancer in Acatalasemic Mice by Vitamin E Supplementation....Pages 440-443
Protective Role of Vitamin E on Iron-Induced Nephrotoxicity and Carcinogenesis: A Model of Free Radical Pathology....Pages 444-447
Evaluation of Oxidative Stress due to X-Irradiation: In Vivo ESR Studies....Pages 448-451
Vitamin E and the Antioxidant Network: Protection of Human Low Density Lipoprotein from Oxidation....Pages 452-459
Macrophages and Vitamin E....Pages 460-464
Effect of α-Tocopherol on Expression of Intercellular Adhesion Molecule-1 and Vascular Adhesion Molecule-1 on Human Vascular Endothelial Cells....Pages 465-467
Effects of Natural Antioxidants on the Activation of Transcription Factor NF-κB and p53....Pages 468-471
Distribution and Biodiscrimination of α-Tocopherol Stereoisomers....Pages 472-478
Scavenging of Singlet Oxygen by α-Tocopherol in Liposomes....Pages 479-482
Free Radical-Scavenging Reactions of α-Tocopherol During the Peroxidation of Unsaturated Lipids....Pages 483-487
Front Matter....Pages 489-489
Dietary Polyunsaturated Fatty Acids and Cancer: Epidemiological and Experimental Studies....Pages 491-494
Effect of Dietary High-Oleic Safflower Oil on Chemically Induced Colon and Mammary Carcinogenesis....Pages 495-498
Chemoprevention of Colon Cancer by Dietary Fatty Acids....Pages 499-504
 Trans Fatty Acids and Cancer....Pages 505-508
Carcinogenesis and Metastasis Are Affected by Dietary n -6/ n -3 Fatty Acids....Pages 509-512
Front Matter....Pages 513-513
Growth Retardation in Human Cervical Dysplasia-Derived Cell Lines by β-Carotene....Pages 515-518
Effects of High Dietary Fat and β-Carotene on Lung Carcinogenesis Induced by Diesel Exhaust Particles....Pages 519-522
Significance of β-Carotene in Cancer....Pages 523-528
Chemopreventive Potential of α-Carotene Against Mouse Liver and Lung Tumor Development: Comparison with β-Carotene and α-Tocopherol....Pages 529-532
Potent Cancer Chemopreventive Activity of α-Carotene Against Carcinogenesis....Pages 533-537
Carotenoids As a Food Factor for Cancer Prevention: Questions to Be Solved....Pages 538-541
Bioavailability, Metabolism, and Possible Mechanism of Chemoprevention by Lutein and Lycopene in Humans....Pages 542-547
Bioavailability of β-Carotene in Humans....Pages 548-551
β-Carotene Metabolism and Cancer....Pages 552-555
Carotenoid Antioxidant Chemistry....Pages 556-561
Lycopene: A New Carotenoid Extracted from Tomatoes....Pages 562-564
Front Matter....Pages 565-565
Antimutagenesis in Somatic Cells of Drosophila as Monitored in the Wing Spot Test....Pages 567-571
Photocleavage of DNA by Chlorophylls and Porphyrins: Electron Transfer from Nucleic Acid Base to Dyes in the Singlet Excited States....Pages 572-576
Inhibition by Chlorella of N -Methylnitrosourea-induced Aberrant Crypt Foci in Rat Colon....Pages 577-580
Inhibitory Activity of Natural Chlorophylls on the Mutagenicity of 4-Nitroquinoline 1-Oxide and 3-Amino-1-Methyl-5 H -Pyrido[4,3- b ]indole in Drosophila ....Pages 581-584
Front Matter....Pages 585-585
Phytoestrogens and Prevention of Cancer....Pages 587-592
Antioxidant Properties of Plant Flavonoids....Pages 593-597
Specific Antimutagenicity of Flavonoids Against Dietary Carcinogen Trp-P-2....Pages 598-602
Structure-Activity Relations of Flavonoids as Antimutagens Against Cooked Food Mutagens and Nitroarenes in the Salmonella Reversion Assay....Pages 603-606
Antitumor-Promoting Activities of Dihydroflavonols from Kohki Tea, the Leaves of Engelhardtia chrysolepis ....Pages 607-612
Front Matter....Pages 585-585
Nutritional Benefits of Flavonoids....Pages 613-616
Protective Effect of αG-Rutin on Oxidative Stress in Mice....Pages 617-622
Effects of Flavonoids on Cell Cycle and Differentiation in Cancer Cells....Pages 623-626
Kinetic Study of Free Radical-Scavenging Action of Flavonoids in Homogeneous and Aqueous Triton X-100 Micellar Solutions....Pages 627-631
Front Matter....Pages 633-633
Effect of L-Carnosine on 8-OH Deoxyguanosine Release by H 2 O 2 in 3Y1 Rat Embryo Fibroblasts....Pages 635-638
Characterization of Antioxidative Peptides from Soybean Proteins....Pages 639-641
Strategy of Chemical Modification to Free Radical Scavengers for Suppression of Hydrogen Peroxide-Induced Cytotoxicity....Pages 642-646
Front Matter....Pages 647-647
Dietary Fiber and Fecal Characteristics in Humans and Animals....Pages 649-653
Large Bowel Enlargement Induced by Dietary Fiber....Pages 654-659
Role of Dietary Fiber in Experimental Diabetes Mellitus....Pages 660-664
Interventional Trial for Colorectal Cancer Prevention in Osaka: An Introduction to Its Protocol....Pages 665-668
Back Matter....Pages 669-677