Flow-Dependent Regulation of Vascular Function

Front Matter....Pages i-x
Front Matter....Pages 1-1
The Design of Fluid Transport Systems: A Comparative Perspective....Pages 3-27
Shear Stress in the Circulation....Pages 28-45
Flow-Mediated Signal Transduction in Endothelial Cells....Pages 46-61
Gene Regulation in Endothelial Cells....Pages 62-84
Flow Effects on Endothelial Cell Signal Transduction, Function, and Mediator Release....Pages 85-116
Front Matter....Pages 117-117
Flow-Induced Vasodilation of Large Arteries: From “Ascending Reflex” to EDRF....Pages 119-127
The Role of Flow-Induced Contraction and Relaxation in the Regulation of Vascular Tone: Results of In Vitro Studies....Pages 128-162
Coronary Microvascular Responses to Flow....Pages 163-177
Endothelium-Derived Relaxing Factor and the Control of Flow in Conduit and Resistance Arteries....Pages 178-213
Regulation of Platelet Function by Flow-Induced Release of Endothelial Autacoids....Pages 214-235
Endothelial Control of Shear Stress and Resistance in the Skeletal Muscle Microcirculation....Pages 236-260
Overview of Regulatory Mechanisms in the Microcirculation....Pages 261-273
Front Matter....Pages 275-275
Blood Flow-Induced Remodeling of the Artery Wall....Pages 277-299
Atherosclerosis and the Role of Wall Shear Stress....Pages 300-319
Role of EDRF/NO in Chronic High Coronary Blood Flow States During Myocardial Dysfunction and Failure....Pages 320-339
Endothelial Role in Coronary Vasospasm and Atherosclerosis....Pages 340-361
Back Matter....Pages 363-371