First International Moxifloxacin Symposium: Berlin, 1999

Front Matter....Pages I-XIII
Introduction to the Symposium....Pages 1-3
Front Matter....Pages 5-5
Antimicrobial Chemotherapy — Today....Pages 7-11
Antimicrobial Chemotherapy—Tomorrow....Pages 12-18
Front Matter....Pages 19-19
Pre-clinical Microbiology — Streptococcus Pneumoniae....Pages 21-26
Pre-clinical Microbiology — Gram-positive Cocci....Pages 27-30
Pre-clinical Microbiology—Atypical Organisms....Pages 31-35
Pre-clinical Microbiology — Summary I....Pages 36-36
Pre-clinical Microbiology — Mycobacteria....Pages 37-42
In-vitro Activity of Moxifloxacin [Bay 12-8039], an 8-methoxy Quinolone, Compared to Other Fluoroquinolones Against Anaerobic Bacteria....Pages 43-48
Pre-clinical Microbiology — Fastidious Gram-negative Bacteria....Pages 49-53
Pre-clinical Microbiology — Respiratory Tract Infections Susceptibility Survey — USA....Pages 54-58
Pre-clinical Microbiology — Respiratory Tract Infections Susceptibility Survey — Europe....Pages 59-66
Pre-clinical Microbiology — Respiratory Tract Infections Susceptibility Survey — Japan....Pages 67-74
Mechanisms of Fluoroquinolone Action and Resistance....Pages 75-83
Pre-clinical Microbiology — Summary II....Pages 84-85
Front Matter....Pages 87-87
Pharmacokinetics and Pharmacodynamics of Antimicrobials....Pages 89-93
Mini-Reviews — Pharmacokinetics/Pharmacodynamics (PK/PD)....Pages 94-97
In vitro Models as Predictors of the Antimicrobial Effect of Moxifloxacin and Other Fluoroquinolones....Pages 98-103
In vitro Models of Infection: Pharmacokinetic/Pharmacodynamic Correlates....Pages 104-110
Animal Model Experiences with Moxifloxacin....Pages 111-117
Front Matter....Pages 87-87
Current Thinking About Pharmacokinetics and Pharmacodynamics of Antimicrobials....Pages 118-121
Pharmacology of Moxifloxacin — Absorption, Distribution, Metabolism and Excretion....Pages 122-126
Antimicrobial Drug-Drug Interactions — Focus on Fluoroquinolones....Pages 127-129
Pharmacology — Tissue Distribution....Pages 130-133
Fluoroquinolone Phototoxicity — Moxifloxacin in Context....Pages 134-137
Fluoroquinolone Safety and Tolerability....Pages 138-143
Front Matter....Pages 145-145
Clinical Needs in the Millennium — Community Acquired Pneumonia....Pages 147-153
Clinical Needs in The Millennium — Pneumonia — The Role of Moxifloxacin....Pages 154-158
Clinical Needs in the Millenium — Acute Exacerbations of Chronic Bronchitis....Pages 159-164
Clinical Needs in the Millennium — Acute Exacerbations of Chronic Bronchitis — The Role of Moxifloxacin....Pages 165-168
Clinical Needs in the Millennium — Rhinosinusitis....Pages 169-173
Clinical Needs in the Millienium — Rhinosinusitis — The Role of Moxifloxacin....Pages 174-177
Discussion on Clinical Needs in the Millennium....Pages 178-180
Front Matter....Pages 181-181
Round Table Discussion — Introduction....Pages 183-183
Round Table Discussion — Hospital Issues....Pages 184-188
Round Table Discussion — Community Issues....Pages 189-190