Field Guide to Optical Biosensing

Terms of use
Copyright
Introduction to the Series
Related Titles from SPIE Press
Preface
Glossary of Symbols and Notation
Introduction and Definitions
	Motivation
	What Is a Biosensor?
	Elements of a Biosensor
	Example: Immunochromatographic Assays
Types of Biosensors
	Non-optical Biosensors
	Optical Biosensors
Background
	History of Biosensors
	Early Milestones in the Development of Biosensors
	Later Milestones in the Development of Biosensors
Surface Functionalization and Immobilization of Bioreceptors
	Immobilization of Bioreceptors
	From Surface Functionalization to Analyte Capture
	Common Bioreceptors
	More Bioreceptors
	Usual Methods of Immobilization
Performance Parameters
	Precision and Accuracy
	Repeatability, Reproducibility, and Selectivity
	Sensitivity
	Measurand, Full-Scale, and Dynamic Ranges
	Signal-to-Noise Ratio
	Minimum Detectable Signal and Saturation
	Time Factors and Stability
Practical Aspects
	Resolution, Threshold, Calibration, and Hysteresis
	Linearity, Offset, and Overload
	Deviations from Ideality (Errors)
	The Ideal Biosensor
Fundamental Optical Sensing Mechanisms
	Fundamental Optical Processes
	Transmission, Absorption, and Scattering
	Optical Phase Difference and Optical Path Difference
	Polarization
	Surface Plasmon Resonance
	Luminescence
	Photoluminescence
	Fluorescence
	Phosphorescence
	Fluorescence Polarization
Detection Methods, Techniques, and Configurations
	Absorbance Biosensors
	Infrared Spectroscopy
	Infrared Vibrational Modes
	Scattering Detection
	Resonance Rayleigh Scattering
	Transduction Based on Reflectance andTransmittance
	Interferometric Biosensors
	Colorimetric Bioassays
	Biosensing Using Ellipsometry
	Photonic Crystals
	Fluorescence-Based Biosensing
	Fluorescence Polarization Detection
	Phosphorescence-Based Biosensing
	Chemiluminescence
	Bioluminescence
	Time-Resolved Fluorescence
	Evanescent Wave Biosensing
	Attenuated Total Reflection Spectroscopy
	Fiber-Optic Biosensors
	Near-Field Scanning Optical Microscopy
	Surface Plasmon Resonance Biosensors
	Real-Time SPR Sensing
	Phase-Sensitive Biosensing
	Optical Heterodyne Detection
	Polarimetry
	Photoacoustic Spectroscopy
	Raman Spectroscopy
	Surface-Enhanced Raman Scattering Detection
	Planar Optical Waveguides and IntegratedOptical Sensors
	Waveguide Interferometer Architectures
	Mach–Zehnder Interferometer
	Young Interferometer
	Hartmann Interferometer
	Dual Polarization Interferometry
	Bimodal Waveguide Interferometers
	Resonant Waveguide Grating
	Antiresonant Reflecting Optical Waveguides
	Hollow Waveguides
	Photonic Crystal Cavity Biosensors
	Resonant Optical Microcavities
	Beyond the Visible and Infrared Ranges
	Integrated Microfluidic Biosensors
	Lab-on-a-Chip Devices
	Bioimaging
Applications
	Medicine
	Infections Caused by Pathogens
	Airborne Diseases
	Point-of-Care Testing Techniques
	Home Monitoring
	Optical Biosensors for Therapeutic Drug Monitoring
	Food Safety
	Common Foodborne Pathogens
	Food Industry
	Biosensors for the Detection of Foodborne Pathogens
	Defense
	Important Biological Warfare Agents
	Some Optical Biosensors for Biological Warfare Agents
	Homeland Security
	Environmental Applications
	Wearable and Implantable Biosensors
	Challenges in Biosensor Commercialization
Equation Summary
References
Index
Author biography