Fetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits

Cover
Fetal Therapy:

Scientific Basis and Critical Appraisal of Clinical Benefits
Copyright
Dedication
Contents
Contributors
Foreword
Section 1. General Principles
1 The Rationale for Fetal Therapy
2 A Fetal Origin of Adult Disease
3 Human Embryology: Molecular Mechanisms of
Embryonic Disease
4 Human Genetics and Fetal Disease: Assessment
of the Fetal Genome
5 Interventions in Pregnancy to Reduce Risk of Stillbirth
6 Fetal Therapy Choices: Uncertain and Emotional
Decisions and the Doctor’s Role in Parental
Decision-Making
7 The Ethics of Consent for Fetal Therapy
8 Open Fetal Surgery: Is There Still a Role?
9 The Artificial Womb
Section 2.
Fetal Disease: Pathogenesis and Treatment
Blood Cell Alloimmunization
10 Management of Red Cell Alloimmunization
11 Fetal and Neonatal Alloimmune Thrombocytopenia:
Clinical Disease and Management
Structural Heart Disease in the Fetus
12 Structural Heart Disease: Embryology
13 Structural Heart Disease: Genetic Influences
14 Deciphering the Mechanisms of Developmental Heart
Disease: Research from Embryonic Knockout Mice
15 In Utero Intervention for Cardiac Disease
16 Fetal Cerebral Consequences of Structural Heart
Disease: Can These Be Ameliorated?
Fetal Dysrhythmias
17 Fetal Supraventricular Tachyarrhythmias:
Pharmacokinetics, Modes of Action, and Results
of Anti-Arrhythmic Drug Therapy
18 Fetal Dysrhythmias: Diagnosis and Clinical
Management
Manipulation of Fetal Amniotic Fluid Volume
19 Manipulation of Amniotic Fluid Volume: Homeostasis
of Fluid Volumes in the Amniotic Cavity
20 Oligohydramnios and Polyhydramnios: Therapeutic
Manipulation of Amniotic Fluid Volume
Fetal Infections
21 Fetal Infections: Immune Response to Infections
during Fetal Life
22 Fetal Infections: Clinical Management
Fetal Growth and Well-being
23 Fetal Growth Restriction: Placental Basis and
Implications for Clinical Practice
24 Fetal Growth Restriction: Diagnosis and Management
25 Screening and Intervention for Fetal
Growth Restriction
26 Maternal and Fetal Therapy: Can We Optimize
Fetal Growth?
Preterm Birth of the Singleton and Multiple Pregnancy
27 The Pathogenesis of Preterm Birth: A Guide to
Potential Therapeutic Targets
28 Clinical Interventions for the Prevention and
Management of Spontaneous Preterm Birth in
the Singleton Fetus
29 Clinical Interventions to Prevent Preterm Birth
in Multiple Pregnancies
30 Reducing Neurologic Morbidity from Preterm Birth
through Administering Therapy Prior to Delivery
Complications of Monochorionic Multiple Pregnancy: Twin-to-TwinTransfusion Syndrome
31 Twin-to-Twin Transfusion Syndrome: Placental
and Fetal Pathogenesis
32 Twin-to-Twin Transfusion Syndrome: Treatment by
Fetoscopic Laser Coagulation of the Placental Vascular
Anastomoses on the Chorionic Plate
33 Interventions for Early and Late Twin-Twin
Transfusion Syndrome
34 Diagnosis and Treatment in Twin Anemia
Polycythemia Sequence
35 Neurological and Long-Term Neurodevelopmental
Outcome after Fetal Therapy in Complicated
Monochorionic Twins
Complications of Monochorionic Multiple Pregnancy: Fetal GrowthRestriction in Monochorionic Twins
36 The Diagnosis and Detection of Fetal Growth
Restriction in Monochorionic Twin Pregnancies
37 Clinical Outcome and Management of Selective
Fetal Growth Restriction in Monochorionic Twins
Complications of Monochorionic Multiple Pregnancy: Twin Reversed ArterialPerfusion Sequence
38 Twin Reversed Arterial Perfusion Sequence:
Pathophysiology and In Utero Treatment
Complications of Monochorionic Multiple Pregnancy: Multifetal Reductionin Multiple Pregnancy
39 Fetal Reduction and Selective Termination
40 Selective Termination of One Fetus in
Monochorionic Twin Pregnancies
Fetal Urinary Tract Obstruction
41 Lower Urinary Tract Obstruction: Pathophysiology,
Prenatal Assessment, and In Utero Intervention
Pleural Effusion and Pulmonary Pathology
42 Fetal Pleural Effusions and Pulmonary Pathology:
Pathophysiology and Clinical Management
Surgical Correction of Neural Tube Anomalies
43 Neural Tube Anomalies: An Update on the
Pathophysiology and Prevention
44 Neural Tube Anomalies: Clinical Management
by Open Fetal Surgery
45 Open Neural Tube Defect Repair: Development and
Refinement of a Fetoscopic Technique
Fetal Tumors
46 Fetal Tumors: Clinical Management
Congenital Diaphragmatic Hernia
47 Congenital Diaphragmatic Hernia: Pathophysiology
and Antenatal Assessment
48 Congenital Diaphragmatic Hernia: In Utero
Treatment Today and Tomorrow
Fetal Stem Cell Transplantation
49 Stem Cell Transplantation: Clinical Potential in
Treating Fetal Genetic Disease
50 Strategies to Repair Defects in the Fetal Membrane
51 Tissue Engineering and the Fetus
Gene Therapy
52 Gene Therapy: Principles and Clinical Potential
Section
3. The Future
53 Fetal Therapy and Translational Studies: Global
Alignment, Coordination, and Collaboration in
Perinatal Research – the Global Obstetrics
Network (GONet) Initiative
54 Congenital Anomaly Registers: The
European Experience
55 A Challenge for Prenatal Diagnosis in Developing
Countries: Zika Virus as an Exemplar
Index