Fetal and Neonatal Physiology

Content: 
Front Matter, Page iii
Copyright, Page iv
Dedication, Page v
CONTRIBUTORS, Pages vii-xx
PREFACE TO THE THIRD EDITION, Page xxi
PREFACE TO THE FIRST EDITION, Pages xxiii-xxiv
Chapter 1 - Basic Genetic Principles, Pages 1-15
Chapter 2 - Molecular Genetics: Developmental and Clinical Implications, Pages 16-25
Chapter 3 - Basic Embryology, Pages 25-40
Chapter 4 - Regulation of Embryogenesis, Pages 41-52
Chapter 5 - The Extracellular Matrix in Development, Pages 52-57
Chapter 6 - Stem Cell Biology, Pages 57-65
Chapter 7 - Homeobox Genes, Pages 65-71
Chapter 8 - Apoptosis and Necrosis, Pages 72-79
Chapter 9 - Angiogenesis, Pages 79-84
Chapter 10 - Placental Development, Pages 85-97
Chapter 11 - Regulation of the Placental Circulation, Pages 97-103
Chapter 12 - Pathophysiology of Preterm Birth, Pages 103-111
Chapter 13 - Mechanisms of Transfer Across the Human Placenta, Pages 111-122
Chapter 14 - Endocrine and Paracrine Function of the Human Placenta, Pages 122-131
Chapter 15 - Fetal and Maternal Responses to Intrauterine Infection, Pages 131-142
Chapter 16 - Maternal Cardiovascular Disease and Fetal Growth and Development, Pages 142-160
Chapter 17 - Fetal Origins of Adult Disease, Pages 160-165
Chapter 18 - Physiologic Effects of Multiple Pregnancy on Mother and Fetus, Pages 165-178
Chapter 19 - Basic Pharmacologic Principles, Pages 179-190
Chapter 20 - Basic Pharmacokinetic Principles, Pages 190-197
Chapter 21 - Physicochemical and Structural Properties Regulating Placental Drug Transfer, Pages 197-211
Chapter 22 - Pharmacogenetics, Pages 211-218
Chapter 23 - Drug Distribution in Fetal Life, Pages 218-227
Chapter 24 - Developmental Pharmacology of Adrenergic Agents, Pages 227-233
Chapter 25 - Maternal Drug Abuse: Effects on the Fetus and Neonate, Pages 234-249
Chapter 26 - Drug Excretion During Lactation, Pages 249-258
Chapter 27 - Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction, Pages 259-265
Chapter 28 - Endocrine Factors Affecting Neonatal Growth, Pages 266-275
Chapter 29 - Human Milk Composition and Function in the Infant, Pages 275-284
Chapter 30 - Physiology of Lactation, Pages 284-290
Chapter 31 - Nutritional Assessment, Pages 291-301
Chapter 32 - Calcium-Regulating Hormones, Pages 303-314
Chapter 33 - Calcium, Phosphorus, and Magnesium Transport Across the Placenta, Pages 314-322
Chapter 34 - Neonatal Calcium, Phosphorus, and Magnesium Homeostasis, Pages 323-341
Chapter 35 - Zinc in the Fetus and Neonate, Pages 342-347
Chapter 36 - Vitamin A Metabolism in the Fetus and Neonate, Pages 347-353
Chapter 37 - Vitamin E Nutrition in the Fetus and Newborn, Pages 353-369
Chapter 38 - Vitamin K Metabolism in the Fetus and Neonate, Pages 369-373
Chapter 39 - Maternal-Fetal Transfer of Lipid Metabolites, Pages 375-388
Chapter 40 - Accretion of Lipid in the Fetus and Newborn, Pages 388-404
Chapter 41 - Brown Adipose Tissue: Development and Function, Pages 404-415
Chapter 42 - Lipids as an Energy Source for the Premature and Full-Term Neonate, Pages 415-418
Chapter 43 - Ketone Body Production and Metabolism in the Fetus and Neonate, Pages 419-428
Chapter 44 - Long Chain Fatty Acids in the Developing Retina and Brain, Pages 429-440
Chapter 45 - Lipoprotein Metabolism and Nutritional Programming in the Fetus and Neonate, Pages 440-447
Chapter 46 - Metabolism of Glucose and Methods of Investigation in the Fetus and Newborn, Pages 449-464
Chapter 47 - Carbohydrate Metabolism During Pregnancy, Pages 464-465
Chapter 48 - Oxygen Consumption and General Carbohydrate Metabolism of the Fetus, Pages 465-478
Chapter 49 - Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period, Pages 478-486
Chapter 50 - Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development, Pages 487-493
Chapter 51 - Pathophysiology of Hypoglycemia, Pages 494-499
Chapter 52 - General Concepts of Protein Metabolism, Pages 501-509
Chapter 53 - Fetal Requirements and Placental Transfer of Nitrogenous Compounds, Pages 509-527
Chapter 54 - Protein and Amino Acid Metabolism and Requirements, Pages 527-539
Chapter 55 - Perinatal Thermal Physiology, Pages 541-548
Chapter 56 - Temperature Control in Newborn Infants, Pages 548-569
Chapter 57 - Physics and Physiology of Human Neonatal Incubation, Pages 570-582
Chapter 58 - Responses of the Fetus and Neonate to Hypothermia, Pages 582-588
Chapter 59 - Structure and Development of the Skin and Cutaneous Appendages, Pages 589-596
Chapter 60 - Physiologic Development of the Skin, Pages 597-611
Chapter 61 - Development of the Fetal Heart, Pages 613-621
Chapter 62 - Molecular Determinants of Embryonic Vascular Development, Pages 621-634
Chapter 63 - Cardiovascular Function During Development and the Response to Hypoxia, Pages 635-669
Chapter 64 - Developmental Electrophysiology in the Fetus and Neonate, Pages 669-689
Chapter 65 - Developmental Biology of the Pulmonary Vasculature, Pages 690-701
Chapter 66 - Development of the Gastrointestinal Circulation in the Fetus and Newborn, Pages 701-705
Chapter 67 - Physiology of Congenital Heart Disease in the Neonate, Pages 705-717
Chapter 68 - Neural Regulation of Blood Pressure During Fetal and Newborn Life, Pages 717-726
Chapter 69 - Programming of the Fetal Circulation, Pages 727-732
Chapter 70 - Physiology of Nitric Oxide in the Developing Lung, Pages 733-743
Chapter 71 - Mechanisms Regulating Closure of the Ductus Arteriosus, Pages 743-748
Chapter 72 - Regulation of Umbilical Blood Flow, Pages 748-758
Chapter 73 - Fetal and Placental Circulation During Labor, Pages 758-765
Chapter 74 - Physiology of Resuscitation, Pages 765-772
Chapter 75 - Pathophysiology of Shock in the Fetus and Neonate, Pages 772-781
Chapter 76 - Normal and Abnormal Structural Development of the Lung, Pages 783-794
Chapter 77 - Regulation of Alveolarization, Pages 794-801
Chapter 78 - Physiologic Mechanisms of Normal and Altered Lung Growth, Pages 802-811
Chapter 79 - Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis, Pages 812-821
Chapter 80 - Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung, Pages 822-834
Chapter 81 - Upper Airway Structure: Function, Regulation, and Development, Pages 834-841
Chapter 82 - Regulation of Lower Airway Function, Pages 842-848
Chapter 83 - Functional Development of Respiratory Muscles, Pages 848-863
Chapter 84 - Mechanics of Breathing, Pages 864-870
Chapter 85 - Pulmonary Gas Exchange in the Developing Lung, Pages 870-880
Chapter 86 - Oxygen Transport and Delivery, Pages 880-889
Chapter 87 - Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate, Pages 890-900
Chapter 88 - Basic Mechanisms of Oxygen-Sensing and Response to Hypoxia, Pages 900-905
Chapter 89 - Pathophysiology of Apnea of Prematurity, Pages 905-918
Chapter 90 - Evaluation of Pulmonary Function in the Neonate, Pages 919-926
Chapter 91 - Pathophysiology of Hyaline Membrane Disease (Excluding Surfactant), Pages 926-934
Chapter 92 - Mechanisms of Neonatal Lung Injury, Pages 934-941
Chapter 93 - Impaired Lung Growth After Injury in Premature Lung, Pages 942-949
Chapter 94 - Antenatal Factors That Influence Postnatal Lung Development and Injury, Pages 949-954
Chapter 95 - Pathophysiology of Bronchopulmonary Dysplasia, Pages 954-961
Chapter 96 - Assisted Ventilation: Physiologic Implications and Complications, Pages 961-978
Chapter 97 - High-Frequency Ventilation, Pages 979-984
Chapter 98 - Liquid Ventilation, Pages 985-1001
Chapter 99 - Historical Perspective, Pages 1003-1005
Chapter 100 - Composition of Pulmonary Surfactant Lipids and Proteins, Pages 1005-1013
Chapter 101 - Physicochemical Aspects of Pulmonary Surfactant, Pages 1014-1034
Chapter 102 - Structure of Alveolar Epithelial Cells and the Surface Layer During Development, Pages 1034-1040
Chapter 103 - Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion, Pages 1041-1054
Chapter 104 - Pathophysiology of Respiratory Distress Syndrome and Surfactant Metabolism, Pages 1055-1068
Chapter 105 - Hormonal Therapy for Prevention of Respiratory Distress Syndrome, Pages 1069-1074
Chapter 106 - Surfactant Treatment, Pages 1074-1085
Chapter 107 - Genetics and Physiology of Surfactant Protein Deficiencies, Pages 1085-1093
Chapter 108 - Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development, Pages 1095-1100
Chapter 109 - Organogenesis of the Gastrointestinal Tract, Pages 1101-1110
Chapter 110 - Development of the Enteric Nervous System, Pages 1110-1117
Chapter 111 - Development of Gastric Secretory Function, Pages 1117-1125
Chapter 112 - Gastrointestinal Motility, Pages 1125-1138
Chapter 113 - Fetal and Neonatal Intestinal Motility, Pages 1139-1142
Chapter 114 - Development of the Exocrine Pancreas, Pages 1142-1151
Chapter 115 - Digestion-Absorption Functions in Fetuses, Infants, and Children, Pages 1151-1162
Chapter 116 - Pathophysiology of Gastroesophageal Reflux, Pages 1163-1168
Chapter 117 - Pathophysiology and Prevention of Neonatal Necrotizing Enterocolitis, Pages 1169-1174
Chapter 118 - Organogenesis and Histologic Development of the Liver, Pages 1175-1179
Chapter 119 - Bile Acid Metabolism During Development, Pages 1179-1186
Chapter 120 - Bile Formation and Cholestasis, Pages 1186-1198
Chapter 121 - Bilirubin Metabolism and Toxicity in the Newborn, Pages 1199-1205
Chapter 122 - Mechanisms of Action of Phototherapy, Pages 1205-1210
Chapter 123 - Pathophysiology of Metabolic Disease of the Liver, Pages 1211-1218
Chapter 124 - Neonatal Cholestasis: Pathophysiology, Etiology, and Treatment, Pages 1218-1221
Chapter 125 - Embryogenesis and Anatomic Development of the Kidney, Pages 1223-1229
Chapter 126 - Functional Development of the Kidney In Utero, Pages 1229-1241
Chapter 127 - Postnatal Maturation of Renal Blood Flow, Pages 1242-1249
Chapter 128 - Development of the Renin-Angiotensin System, Pages 1249-1256
Chapter 129 - Postnatal Development of Glomerular Filtration Rate in Neonates, Pages 1256-1266
Chapter 130 - Renal Transport of Sodium During Early Development, Pages 1267-1278
Chapter 131 - Potassium Homeostasis in the Fetus and Neonate, Pages 1279-1286
Chapter 132 - Role of the Kidney in Calcium and Phosphorus Homeostasis, Pages 1286-1294
Chapter 133 - Transport of Amino Acids During Early Development, Pages 1294-1298
Chapter 134 - Developmental Aspects of Organic Acid Transport, Pages 1299-1302
Chapter 135 - Concentration and Dilution of the Urine, Pages 1303-1327
Chapter 136 - Urinary Acidification, Pages 1327-1330
Chapter 137 - Response to Nephron Loss in Early Development, Pages 1330-1335
Chapter 138 - Pathophysiology of Acute Renal Failure in the Neonatal Period, Pages 1335-1340
Chapter 139 - Fluid Distribution in the Fetus and Neonate, Pages 1341-1350
Chapter 140 - Fetal and Neonatal Body Water Compartment Volumes with Reference to Growth and Development, Pages 1351-1356
Chapter 141 - Pathophysiology of Edema, Pages 1357-1361
Chapter 142 - Regulation of Acid-Base Balance in the Fetus and Neonate, Pages 1361-1364
Chapter 143 - Biology of Stem Cells and Stem Cell Transplantation, Pages 1365-1373
Chapter 144 - Developmental Biology of the Hematopoietic Growth Factors, Pages 1374-1387
Chapter 145 - Developmental Granulocytopoiesis, Pages 1388-1396
Chapter 146 - Developmental Erythropoiesis, Pages 1397-1420
Chapter 147 - Developmental Megakaryocytopoiesis in Fetal and Neonatal Physiology, Pages 1421-1433
Chapter 148 - Developmental Hemostasis, Pages 1435-1447
Chapter 149 - Pathophysiology of Bleeding Disorders in the Newborn, Pages 1447-1460
Chapter 150 - Pathophysiology of Neonatal Disseminated Intravascular Coagulation and Thrombosis, Pages 1460-1473
Chapter 151 - Host Defense Mechanisms Against Bacteria, Pages 1475-1486
Chapter 152 - Host Defense Mechanisms Against Fungi, Pages 1487-1489
Chapter 153 - Host Defense Mechanisms Against Viruses, Pages 1490-1511
Chapter 154 - T-Cell Development, Pages 1512-1518
Chapter 155 - B-Cell Development, Pages 1518-1522
Chapter 156 - Mononuclear Phagocyte System, Pages 1523-1538
Chapter 157 - Neonatal Neutrophil Normal and Abnormal Physiology, Pages 1538-1549
Chapter 158 - The Complement System of the Fetus and Neonate, Pages 1549-1555
Chapter 159 - Cytokines and Inflammatory Response in the Fetus and Neonate, Pages 1555-1572
Chapter 160 - Integrins and Cell Adhesion Molecules, Pages 1572-1591
Chapter 161 - Stimulus-Response Coupling in Phagocytic Cells, Pages 1591-1604
Chapter 162 - Fetal Wound Healing, Pages 1604-1610
Chapter 163 - Immunology of Human Milk and Host Immunity, Pages 1610-1620
Chapter 164 - Neonatal Pulmonary Host Defense Mechanisms, Pages 1620-1673
Chapter 165 - Development of the Nervous System, Pages 1675-1698
Chapter 166 - Development of the Blood-Brain Barrier, Pages 1699-1706
Chapter 167 - Development of Neurotransmitters, Pages 1706-1713
Chapter 168 - Perinatal Brain Metabolism, Pages 1713-1725
Chapter 169 - Electroencephalography in the Premature and Full-Term Infant, Pages 1726-1745
Chapter 170 - Cerebral Blood Flow in Premature Infants: Regulation, Measurement, and Pathophysiology of Intraventricular Hemorrhage, Pages 1745-1756
Chapter 171 - Pathophysiology of Intraventricular Hemorrhage in the Neonate, Pages 1757-1772
Chapter 172 - Pathophysiology of Neural Tube Defects, Pages 1772-1785
Chapter 173 - Trophic Factor and Nutritional and Hormonal Regulation of Brain Development, Pages 1785-1792
Chapter 174 - Development of Pain Sensation, Pages 1792-1796
Chapter 175 - Retinal Development and the Pathophysiology of Retinopathy of Prematurity, Pages 1797-1802
Chapter 176 - Early Development of the Human Auditory System, Pages 1803-1819
Chapter 177 - Development of Taste and Smell in the Neonate, Pages 1819-1827
Chapter 178 - The Growth Plate: Embryologic Origin, Structure, and Function, Pages 1829-1838
Chapter 179 - Common Musculoskeletal Conditions Related to Intrauterine Compression: Effects of Mechanics on Endochondral Ossification, Pages 1838-1844
Chapter 180 - Defective Limb Embryology, Pages 1844-1849
Chapter 181 - Ontogenesis of Striated Muscle, Pages 1849-1870
Chapter 182 - Hypothalamus: Neuroendometabolic Center, Pages 1871-1880
Chapter 183 - Growth Factor Regulation of Fetal Growth, Pages 1880-1890
Chapter 184 - Growth Hormone and Prolactin, Pages 1891-1895
Chapter 185 - Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn Infant, Pages 1896-1906
Chapter 186 - Development of the Corticotropin-Releasing Hormone–Corticotropin/β-Endorphin System in the Mammalian Fetus, Pages 1907-1914
Chapter 187 - Fetal and Neonatal Adrenocortical Physiology, Pages 1915-1925
Chapter 188 - Fetal and Neonatal Thyroid Physiology, Pages 1926-1933
Chapter 189 - Genetics of Sex Determination and Differentiation, Pages 1935-1941
Chapter 190 - Differentiation of the Ovary, Pages 1941-1949
Chapter 191 - Testicular Development, Pages 1950-1955
Chapter 192 - Testicular Descent, Pages 1956-1960
INDEX, Pages i-xlviii