Fatigue in Cancer

Contents......Page 10
List of contributors......Page 14
Why consider fatigue in cancer?......Page 18
How important is fatigue in cancer?......Page 19
Uncertainties regarding assessment, treatment, and future care......Page 20
Part 1 The nature and pathophysiology of fatigue......Page 24
Definitions......Page 26
Epidemiology of fatigue in the general population......Page 27
The epidemiology of fatigue in cancer......Page 32
Models of fatigue......Page 39
Conclusions......Page 43
Treatment-related fatigue......Page 52
Relationship of cancer-related fatigue with side-effects and symptoms of disease and treatment......Page 64
Implications for practice and research......Page 65
Conclusion......Page 67
Introduction......Page 74
Is fatigue a biologically appropriate response to cancer and therapy?......Page 76
Challenges in studying the mechanism(s) of fatigue......Page 78
What is the origin of the sensation of fatigue?......Page 81
Mechanisms and models of cancer-related fatigue......Page 84
Conditions that may covary with fatigue......Page 95
Closing comment......Page 99
Definitions and frequency of anorexia/cachexia and cancer-related fatigue......Page 112
Mechanisms of cachexia/anorexia and their relationship with fatigue......Page 113
Clinical assessment......Page 122
Management of cancer anorexia/cachexia syndrome with reference to cancer-related fatigue......Page 125
Approaches to fatigue management......Page 131
Psychological and spiritual issues......Page 132
Future perspectives......Page 133
Part 2 The experience of fatigue......Page 144
Introduction......Page 146
Lay perceptions and the potential for contextually relevant healthcare......Page 147
Fatigue, health, and well-being......Page 148
Constructing the fatigue experience......Page 152
Lay perceptions of cancer-related fatigue: an emergent model......Page 154
Introduction......Page 160
The nature of fatigue......Page 166
Cancer-related fatigue and alterations in bodily awareness......Page 167
Physical and cognitive effects of cancer-related fatigue......Page 168
Social effects of fatigue......Page 169
Effect of cancer-related fatigue on perceptions of self......Page 170
The emotional experience of cancer-related fatigue: suffering......Page 171
Coping with cancer-related fatigue......Page 173
Implications for practice and research......Page 174
Conclusion......Page 175
Introduction......Page 180
Caring and carers......Page 181
Cancer and caring......Page 182
Factors affecting carers’ perceptions of fatigue......Page 183
Emotions: sustaining caring and emotion work......Page 186
Caring in isolation......Page 188
The exhaustion of uncertainty......Page 191
Recommendations for research and practice......Page 193
Conclusion......Page 194
Introduction......Page 198
Fatigue in children and adolescents with cancer: definitions, causes, and coping......Page 199
Impact of the child’s fatigue on the family......Page 203
Coping strategies......Page 207
Implications for practice development......Page 208
Future directions for practice and research......Page 210
Part 3 The assessment and management of fatigue......Page 214
Introduction......Page 216
Clinical assessment of fatigue and weakness......Page 217
The validity and reliability of fatigue questionnaires......Page 222
A critique of the methodology of fatigue research......Page 234
Implications for practice and research......Page 237
Conclusion......Page 238
What are the conceptual similarities and differences between fatigue and depression?......Page 246
To what extent are fatigue and depression related and how might they be distinguished?......Page 250
What are the causal relationships between fatigue and depression?......Page 254
What are the treatment implications of relationships between fatigue and depression?......Page 256
Conclusions......Page 259
Components of mental fatigue......Page 266
Components of cognitive dysfunction......Page 267
Aetiology of mental fatigue......Page 270
Assessment and measurement......Page 271
Interventions......Page 272
Conclusion......Page 273
Introduction......Page 278
Pharmacological interventions......Page 279
Non-pharmacological interventions......Page 285
Future directions for research......Page 291
Conclusion......Page 294
Introduction......Page 302
A model of the relationship between capacity and performance......Page 303
Why distinguish between capacity and performance?......Page 306
The observation of skilled performance......Page 307
Implications for the evaluation/measurement of fatigue and function......Page 308
Importance for developing effective intervention strategies......Page 309
Introduction......Page 314
The physiological effects of exercise......Page 315
The psychological effects of exercise......Page 319
Implications for practice and research......Page 321
Conclusion......Page 324
C......Page 330
D......Page 331
I......Page 332
P......Page 333
Z......Page 334