Fate of pesticides in large animals

Front Cover......Page 1
Fate of Pesticides in Large Animals......Page 4
Copyright Page......Page 5
Table of Contents......Page 6
Contributors......Page 8
Preface......Page 10
INTRODUCTION......Page 14
TOXICOLOGICAL SIGNIFICANCE AND HAZARD EVALUATION......Page 15
PRACTICAL CONSIDERATIONS......Page 23
REFERENCES......Page 27
INTRODUCTION......Page 30
GENERAL DISCUSSION AND COMMENTS......Page 46
REFERENCES......Page 47
CHAPTER 3. METABOLISM STUDIES OF PESTICIDES IN LARGE ANIMALS: A GENERAL DISCUSSION ON REGULATORY CONSIDERATIONS......Page 60
OBJECTIVE, SCOPE, AND TOXICOLOGICAL BASIS......Page 61
SELECTION OF ANIMAL SPECIES......Page 62
HOUSING CONDITIONS......Page 63
ACKNOWLEDGEMENT......Page 64
INTRODUCTION......Page 66
SUMMARY OF STUDIES WITH PHENOXY HERBICIDES IN ANIMALS......Page 68
PHARMACOKINETIC STUDIES......Page 73
RESIDUES IN ANIMAL TISSUES......Page 77
DISCUSSION......Page 85
REFERENCES......Page 87
CHAPTER 5. COMPARATIVE METABOLISM AND AN EXPERIMENTAL APPROACH FOR STUDY OF LIVER OXIDASE INDUCTION IN PRIMATES......Page 90
INTRODUCTION......Page 91
SUBHUMAN PRIMATES AS RESEARCH ANIMALS......Page 92
USE AND CLASSIFICATION OF PRIMATES......Page 93
COMPARATIVE METABOLISM IN LIVING THINGS......Page 95
EXPERIMENTAL: CONTINUAL ASSESSMENT OF LIVER OXIDASE ACTIVITY IN RHESUS MONKEYS FED DDT......Page 105
CONCLUSIONS......Page 117
REFERENCES......Page 118
INTRODUCTION......Page 124
METABOLISM OF INSECT JUVENILE HORMONES AND ANALOGS......Page 125
METABOLISM OF DIFLUBENZURON IN RUMINANTS AND INSECTS......Page 128
ACKNOWLEDGMENT......Page 136
REFERENCES......Page 137
INTRODUCTION......Page 140
GENERAL CONSIDERATIONS......Page 141
COMPARATIVE FUNGICIDE METABOLISM......Page 143
DISCUSSION......Page 166
REFERENCES......Page 167
INTRODUCTION......Page 172
DATA BASE......Page 173
MODEL......Page 174
RESULTS......Page 177
DISCUSSION......Page 182
CONCLUSIONS AND APPLICATIONS......Page 184
REFERENCES......Page 185
INTRODUCTION......Page 188
EXPERIMENTAL......Page 190
RESULTS AND DISCUSSION......Page 191
REFERENCES......Page 195
CHAPTER 10. MIREX, CHLORDANE, DIELDRIN, DDT, AND PCB'S: METABOLITES AND PHOTOISOMERS IN L. ONTARIO HERRING GULLS......Page 196
REFERENCES......Page 204
INTRODUCTION......Page 206
EXPERIMENTAL......Page 208
RESULTS AND DISCUSSION......Page 212
REFERENCES......Page 227
CHAPTER 12. THE FATE OF PHENYL N,N'-DIMETHYLPHOSPHORODIAMIDATE IN ANIMALS......Page 230
INTRODUCTION......Page 231
RAT METABOLISM......Page 233
CATTLE METABOLISM......Page 242
DISCUSSION......Page 243
REFERENCES......Page 244
CHAPTER 13. METABOLISM OF CRONETON ( 2–ETHYLTHIOMETHYLPHENYL N–METHYLCARBAMATE) IN LARGE ANIMALS......Page 246
MATERIALS AND METHODS......Page 247
RESULTS......Page 251
DISCUSSION......Page 262
REFERENCES......Page 264
INTRODUCTION......Page 266
ANALYSIS OF HUMAN LIVER SAMPLES......Page 268
ACKNOWLEDGEMENT......Page 277
REFERENCES......Page 278
Index......Page 280