Experimental Lung Cancer: Carcinogenesis and Bioassays

Front Matter....Pages I-XIII
Keynote Address: Progress in Respiratory Carcinogenesis....Pages 1-5
Front Matter....Pages N1-N1
Models in Chemical Respiratory Carcinogenesis....Pages 7-19
The Role of the Host in the Development of in vivo Models for Carcinogenesis Studies....Pages 20-47
The Significance of Aryl Hydrocarbon Hydroxylase Enzyme Systems in the Selection of Model Systems for Respiratory Carcinogenesis....Pages 48-61
Pulmonary Carcinogenesis by Two Aryl Hydrocarbons on Three Mouse Strains....Pages 62-71
Cell-Mediated Immunity after Intratracheal Exposure to 3-Methylcholanthrene, and its Relationship to Tumor Transplant Growth in C3H/f Mai Mice....Pages 72-80
The Influence of Carcinogenic Substances Introduced Intratracheally to Several Generations of Experimental Rats....Pages 81-85
Large-Volume Intratracheal Instillation of Particulate Suspensions to Hamsters....Pages 86-91
The Intrapleural Route as a Means for Estimating Carcinogenicity....Pages 92-101
Localized Submucosal Bronchial Injections of Carcinogens in Dogs....Pages 102-115
Studies of Intrabronchial Particle Deposition Using Hollow Bronchial Casts....Pages 116-127
The Distribution and Retention of Selected Metals in Rat Tissue after Inhalation of Cadmium Oxide Aerosols....Pages 128-138
Conception and Methods of Experimental Studies in Germany to Estimate the Carcinogenic Burden by Air Pollution in Man....Pages 139-145
Experimental Carcinogenicity and Bioassays of Automobile Exhaust Condensate and Its Polycyclic Aromatic Hydrocarbons....Pages 146-156
Front Matter....Pages N3-N3
Review and Introductory Remarks: Multifactorial Respiratory Carcinogenesis....Pages 157-160
Morphogenesis of Experimental Lung Tumors in Hamsters: The Effects of Carrier Dust....Pages 161-172
Role of Particles in Respiratory Carcinogenesis Bioassay....Pages 173-185
Effect of Particulate Benzo(a)pyrene Carrier on Carcinogenesis in the Respiratory Tract of Hamsters....Pages 186-198
Chemical Induction of Lung Carcinomas in Rats....Pages 199-206
Synergistic Effects of Benzo(a)pyrene and N-Methyl-N-Nitrosourea on Respiratory Carcinogenesis in Syrian Golden Hamsters....Pages 207-218
Front Matter....Pages N3-N3
The Effects of Particulates on Respiratory Carcinogenesis by Diethylnitrosamine....Pages 219-233
Respiratory Cocarcinogenesis Studies with Ferric Oxide: A Test Case of Current Experimental Models....Pages 234-245
Induction of Pulmonary Tumors in Mice by Oral Administration of a 5-Nitrofuran Derivative....Pages 246-256
Surface Morphology of Tracheal Epithelium in Vitamin A Deficiency and Reversal....Pages 257-264
Postinfluenzal Pulmonary Lesions in Vitamin A Deficient Mice....Pages 265-273
Influenza-Virus-Induced Hyperplasia of the Respiratory Tract of the Hamster....Pages 274-279
Inoculation of Owl Monkeys ( Aotus trivirgatus ) with 7,12-Dimethylbenz(a)anthracene and Herpesvirus saimiri . Induction of Epidermoid Carcinoma in the Lung....Pages 280-291
Front Matter....Pages N5-N5
Review and Introductory Remarks: Bioassays of Respiratory Carcinogens in Tobacco Products....Pages 293-299
A Modified Method for Locating Labeled Smoke Particles in Organs of Syrian Golden and European Hamsters....Pages 300-308
Dotriacontane-16, 17- 14 C Distribution Pattern in the Respiratory System of Two Hamster Species after Passive Exposure to Radioactive Labelled Smoke....Pages 309-319
Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters....Pages 320-330
Tumorigenic Effect of Chronic Cigarette Smoke Inhalation on Syrian Golden Hamsters....Pages 331-359
Effect of Chronic Exposure to Cigarette Smoke on Tumor Incidence in the Syrian Golden Hamster....Pages 360-368
Carcinogenicity of Inhaled Cigarette Smoke in the NMU-Pretreated Hamster Larynx....Pages 369-382
Validity of the Sebaceous Gland Test and the Hyperplasia Test for the Prediction of the Carcinogenicity of Cigarette Smoke Condensates and Their Fractions....Pages 383-391
Squamous Carcinoma of the Lung from Cigarette Smoke Condensate in Implanted Beeswax Pellets....Pages 392-400
Front Matter....Pages N7-N7
Radiation Carcinogenesis. Introductory Remarks....Pages 401-401
The Effects of Inhaled Uranium Mine Air Contaminants in Beagle Dogs....Pages 403-410
Lesions and Lung Cancers Induced in Rats by Inhaled Radon 222 at Various Equilibriums with Radon Daughters....Pages 411-421
Studies of Pulmonary Carcinogenesis in Rodents Following Inhalation of Transuranic Compounds....Pages 422-429
Front Matter....Pages N7-N7
Lung Irradiation with Static Plutonium Microspheres....Pages 430-442
Respiratory Carcinogenesis in Rats after Inhalation of Radioactive Aerosols of Actinides and Lanthanides in Various Physicochemical Forms....Pages 443-453
Pulmonary Carcinogenesis and Chronic Beta Irradiation of Lung....Pages 454-467
Histologic Observations on the Pathogenesis of Lung Cancer in Hamsters Following Administration of Polonium-210....Pages 468-474
Cellular Localization of Intratracheally Administered 210 PO in the Hamster Lung Using Autoradiography of Thin Sections from Plastic Embedded Tissue....Pages 475-484
Experimental Respiratory Carcinogenesis: Interaction between Alpha Radiation and Benzo (a) pyrene in the Hamster....Pages 485-491
Front Matter....Pages N9-N9
Review and Introductory Remarks: The Role of Organ Culture and Cell Culture Methods in Studies of Respiratory Carcinogenesis and Anti-Carcinogenesis....Pages 493-496
Interactions between Radiation and Benzo(a)pyrene in an in vitro Model for Malignant Transformation....Pages 497-506
Dose Dependence of Carcinogen-Induced Changes in Tracheal Epithelium in Organ Culture....Pages 507-513
Topical Application of Polycyclic Hydrocarbons to Differentiated Respiratory Epithelium in Long-Term Organ Cultures....Pages 514-520
The Bioassay of Carcinogenesis: Effects on the Epithelial Cell Complement of Rat Tracheae Maintained in vitro ....Pages 521-531
Effects of Cigarette Smoke Condensate (CSC) on Rat Fetal Lung in Organ Culture....Pages 532-538
Tracheal Grafts....Pages 539-547
Studies of Ultrastructure, Cytochemistry, and Organ Culture of Human Bronchial Epithelium....Pages 548-563
Studies on Carcinogen Binding in vitro in Isolated Hamster Tracheas....Pages 564-574
The Reversal of Keratinized Squamous Metaplastic Lesions of Vitamin A Deficiency in Tracheobronchial Epithelium by Vitamin A and Vitamin A Analogs in Organ Culture: A Model System for Anti-Carcinogenesis Studies....Pages 575-582
Transformation of Nonvirus Producing BALB/3T3 Cells by an Environmental Extract....Pages 583-589
Concluding Remarks: Progress in Respiratory Carcinogenesis Bioassays....Pages 590-591
Back Matter....Pages 593-611