Experimental Glycoscience: Glycobiology

Front Matter....Pages I-XVIII
Front Matter....Pages 1-1
Convenient Synthesis of Glycan-Related Oligosaccharides and Their Transformation into Neoglycoconjugates Using Enzymatic Methods....Pages 5-8
Comparison of Glycosyltransferase Families Using the Profile Hidden Markov Model....Pages 9-12
 N -Acetylglucosaminyltransferases Involved in N -Glycan Biosynthesis....Pages 13-15
UDP- N -Acetyl- d -Galactosamine:polypeptide N -Acetylgalactosaminyltransferases (ppGaNTases, pp-GalNAc-Ts, EC 2.4.1.41)....Pages 16-18
Glycosyltransferase Family with β4GT Motif (β4Gal-T and β4GalNAc-T Family)....Pages 19-23
β1,3-glycosyltransferase Gene Family and IGnT Gene Family....Pages 24-29
 O -Mannosyltransferase and POMGnT1....Pages 30-32
Glycosyltransferases Involved in O-fucose Glycan Synthesis....Pages 33-35
Fucosyltransferase (α1,2/ α1,3/ α1,4-fucosyltransferases)....Pages 36-38
FUT8 Assay....Pages 39-41
Sialyltransferases....Pages 42-46
Glucuronyltransferases Involved in the HNK-1 Biosynthesis....Pages 47-49
α1,4-Linkage Glycosyltransferases....Pages 50-52
Glycosyltransferases Involved in the Biosynthesis of Glycolipids....Pages 53-55
Sialyltransferases and Other Enzymes Involved in the Biosynthesis of Gangliosides....Pages 56-58
Heparan Sulfate Synthases and Related Genes....Pages 59-63
Chondroitin Sulfate Biosynthesis and Related Genes....Pages 64-66
Biosynthesis of Keratan Sulfate....Pages 67-69
Hyaluronan Synthase Assay....Pages 70-71
Glycosylphosphatidylinositol-Anchored Protein Biosynthesis and Related Genes in Mammalian Cells....Pages 72-75
Front Matter....Pages 1-1
Processing Enzymes Involved in N -glycan Biosynthesis and Related Genes: the Golgi N -glycan Processing α-mannosidase II and α-mannosidase IIx....Pages 111-114
Sialidase Genes....Pages 115-118
Release of Sugar Chains from Glycosphingolipids....Pages 119-122
Heparan Sulfate Endosulfatase Assay....Pages 123-124
Sphingolipid Activator Proteins....Pages 125-129
Affinity Purification of Recombinant Galectins....Pages 133-135
Siglec Family....Pages 136-140
Cloning of Genes for N-linked Oligosaccharide Synthesis in Endoplasmic Reticulum....Pages 76-79
 N -acetylglucosamine-6- O -sulfotransferases....Pages 83-86
Sulfotransferases Involved in Sulfation of Glycosaminoglycans....Pages 87-93
Sulfatide Synthase....Pages 94-96
CMP- N -acetylneuraminic Acid Hydroxylase....Pages 97-99
Nucleotide Sugar Transporter Genes and Their Functional Analysis....Pages 103-107
Front Matter....Pages 141-141
NKT Cells and Their Recognition of Glycolipids....Pages 145-147
Carbohydrate Ligands for Selectins in Immune Cell Trafficking....Pages 148-153
Carbohydrate Recognition by Cytokines and Its Relevance to Their Physiological Activities....Pages 154-157
Detection of Mouse MGL1/CD301a by a Specific Monoclonal Antibody....Pages 158-161
Roles of Serum Lectins in Host Defense....Pages 162-166
Siglec-2 Is a Key Molecule for Immune Response....Pages 167-170
Galectin and Immune System: Toward Clinical Applications....Pages 171-173
Front Matter....Pages 141-141
A Cytoplasmic Peptide: N -Glycanase and ER-Associated Degradation....Pages 201-203
Ubiquitination of Glycoproteins in the Cytosol....Pages 204-206
Degradation of Misfolded Glycoproteins in the Endoplasmic Reticulum....Pages 207-210
Fucosylation and Cancer....Pages 235-237
Biological Significance of Mucins Produced by Epithelial Cancer Cells....Pages 238-242
Regulation of Glycosyltransferases for O-Glycan Core Structure in Cancer and Their Relations to Metastasis....Pages 243-245
Roles of Carbohydrate-Mediated Cell Adhesion in Cancer Progression....Pages 246-251
Retrograde Transport of Glycolipid-Bound Toxins....Pages 213-215
Degradation of Hyaluronan and Its Disorder....Pages 216-218
Recent Advances in Enzyme Replacement Therapy for Lysosomal Diseases....Pages 219-221
Developing an Assay System for the Hemagglutinin Mutations Responsible for the Binding of Highly Pathogenic Avian Influenza A Viruses to Human-Type Receptors....Pages 225-226
 Helicobacter pylori Growth Assay for Glycans....Pages 227-229
Binding Properties of Clostridium botulinum Type C Progenitor Toxin....Pages 230-232
Novel Glycolipids in Developing Brain: Determination by Nano-LC/MS/MS....Pages 177-179
Functional Roles of the HNK-1 Carbohydrate and Polysialic Acid in the Nervous System....Pages 180-181
Neuronal Function of Sulfatide....Pages 182-184
Accumulation of Alzheimer β-amyloid via Ganglioside Clusters....Pages 185-187
Chondroitin Sulfate Proteoglycans and Neuronal Network Formation....Pages 188-191
Processing of Glycosyltransferases by Alzheimer’s β-secretase (BACE1)....Pages 192-194
Chondroitin Sulfate Proteoglycans: A Key Substance for Central Nervous System Injury Repair....Pages 195-198
Front Matter....Pages 141-141
Proteoglycans in Tissue Regeneration....Pages 257-261
Stem Cell Glycobiology....Pages 262-264
Human Embryonic Stem (ES) Cells and Induced Pluripotent Stem (iPS) Cells Are Defined by Carbohydrate Markers....Pages 265-266
Glycoantigens in Xenotransplantation....Pages 267-271
Congenital Muscular Dystrophies Due to the Glycosylation Defect....Pages 315-318
Molecular Diagnosis of Congenital Disorders of Glycosylation....Pages 319-322
Research in Japan Has Contributed to the Understanding of GPI Anchor Deficiency....Pages 323-325
Conditional Transgenic Mouse of Hyaluronan Synthase: A Potential Model of Advanced Breast Cancer....Pages 252-254
Glycoconjugates in Spermatogenesis....Pages 275-277
Recognition Mechanism of Egg and Sperm Based on Sugar Chains....Pages 278-281
Aberrant Expression of Sialidase in Cancer and Diabetes....Pages 329-332
Insulin Resistance and Type 2 Diabetes as Microdomain Disease: Implication of Ganglioside GM3....Pages 333-336
Incompleteness of O -glycans at the Hinge Region of IgA1 and IgA Nephropathy....Pages 339-342
β4-Galactosyltransferase Deficiency and IgA Nephropathy....Pages 343-345
Functional Analysis of Sugar Chains Using a Genome-Wide RNAi System in Drosophila ....Pages 285-289
Functional Glycomics at the Level of Single Cells: Studying Roles of Sugars in Cell Division, Differentiation, and Morphogenesis with 4D Microscopy....Pages 290-294
Studies on Functions of Notch O -Fucosylation in Drosophila ....Pages 295-298
Membrane Microdomain as a Platform of Carbohydrate-Mediated Interactions During Early Development of Medaka Fish....Pages 299-302
Functions of Heparan Sulfate Proteoglycans in Morphogenesis....Pages 303-308
Fukutin and Fukuyama Congenital Muscular Dystrophy....Pages 309-312
Front Matter....Pages 141-141
Glycosyltransferases Involved in the Biosynthesis of IgA O -Glycans....Pages 346-346
Importance of Sugar Chains in the Function of Growth Factor Receptors....Pages 349-350
Analysis of N -glycan of Growth Factor Receptors....Pages 351-354
The Midkine Family and Its Receptors....Pages 355-357
 N -glycans Regulate Integrin α5β1 Functions....Pages 358-359
Blood Group Antigens: Blood Group Carbohydrate Antigens....Pages 363-365
Bombay, Lewis and Ii Blood Group Antigens on Human Erythrocytes....Pages 366-368
Blood Cells in Glycobiology....Pages 369-372
Front Matter....Pages 373-373
Fucosyltransferase-9 Knockout Mouse....Pages 377-378
Knockout Mice of α1,6 Fucosyltransferase (Fut 8)....Pages 379-380
Glucuronyltransferase (GlcAT-P) Gene-Deficient Mice....Pages 381-382
KO Mice of β1,4-galactosyltransferase-I....Pages 383-385
Sulfotransferases....Pages 386-388
KO Mice of Cerebroside Sulfotransferase....Pages 389-390
KO Mice of β1,4- N -acetylgalactosaminyltransferase (GM2/GD2 Synthase)....Pages 391-393
KO Mice of α-2,8-sialyltransferase (GD3 Synthase)....Pages 394-395
Double KO Mice of β-1,4- N -acetylgalactosaminyltransferase (GM2/GD2 Synthase) and α-2,8-sialyltransferase (GD3 Synthase)....Pages 396-398
Front Matter....Pages 399-399
Cell Lines for Glycobiology....Pages 403-406
Sugar Chain-Related Genes: Glycosyltransferases Expression System....Pages 407-409
GALAXY Database and Pyridylaminated Oligosaccharide Library....Pages 413-416
Front Matter....Pages 399-399
Mass Production of Sugar Intermediates for the Synthesis of Functional Oligosaccharides....Pages 417-419
A Database System for Glycogenes (GGDB)....Pages 423-425
CabosDB: Carbohydrate Sequencing Database....Pages 426-428
GlycoEpitope: A Database of Carbohydrate Epitopes and Antibodies....Pages 429-431
A Novel Lectin-Affinity Database for Structural Glycomics....Pages 432-434
Glycoconjugate Data Bank....Pages 435-440
KEGG GLYCAN for Integrated Analysis of Pathways, Genes, and Structures....Pages 441-444
DNA Microarray in Glycobiology....Pages 447-450
Lectin Microarray....Pages 451-454
Carbohydrate Microarray for Deciphering the Information Embedded in Oligosaccharide Structures....Pages 455-458
Back Matter....Pages 459-498