Experimental and Clinical Effects of L-Asparaginase

Front Matter....Pages I-XI
Opening Remarks....Pages 1-2
Asparaginase and Cancer — Yesterday and Today....Pages 3-14
L-Asparaginase: Early Findings and Current Studies on the Metabolism of L-Asparagine in Lymphoma Cells....Pages 15-21
Studies on the Control of Asparagine Biosynthesis in Mammalian Tissues....Pages 22-30
Isolation and Crystallisation of L-Asparaginase from E. coli....Pages 31-38
Biochemical Characterization of L-Asparaginases from E. coli....Pages 39-47
Some Physicochemical Aspects of L-Asparaginase Therapy....Pages 48-57
The Distribution and Clearance of L-Asparaginase....Pages 58-63
Pharmacokinetic Behavior of L-Asparaginase in Men and in Animals....Pages 64-74
The Partitioning of L-Asparaginase between Blood and Lymph....Pages 75-80
Critical Influence of an Enzyme-Elevating Virus upon Long-Term Remissions of Mouse Leukemia Following Asparaginase Therapy....Pages 81-101
Experimental Studies with L-Asparaginase in Mouse Leukemias....Pages 102-113
Experimental Investigations on Problems of the Clinical Use of L-Asparaginase....Pages 114-124
Studies on the Glutaminase Activity of E. coli Asparaginase in Tissue Culture....Pages 125-130
L-Asparaginase in the Treatment of Neoplastic Diseases of the Dog, Cat and Cow....Pages 131-139
The Cytomorphological Effects of L-Asparaginase in Sensitive Cells....Pages 140-150
Inhibitation by L-Asparaginase from E. coli of Human Malignant Melanoma Cells Growing in vitro....Pages 151-154
Influence of L-Asparaginase Preparations of E. coli and Agouti Serum on the Homograft Reactivity in the Mouse....Pages 155-159
Studies on the Immunosuppressive Activity of L-Asparaginase....Pages 160-169
Experimental Immunosuppression with L-Asparaginase....Pages 170-173
Experimental Studies on the Toxicity of Crasnitin in Animals....Pages 174-180
The Effect of Asparaginase on Some Animal-Tumors....Pages 181-187
Studies of Resistance to L-Asparaginase in Human Leukemia....Pages 188-193
The Antigenicity of E. coli-Asparaginase....Pages 194-197
Studies on Antibody Formation in Patients Treated with L-Asparaginase....Pages 198-203
Treatment of Acute Leukemia with L-Asparaginase....Pages 204-218
Clinical Experience with L-Asparaginase....Pages 219-235
Clinical Experience with L-Asparaginase....Pages 236-243
Result of a Cooperative Study with L-Asparaginase in Human Leukemias....Pages 244-256
Clinical Experience with L-Asparaginase....Pages 257-262
Treatment of Acute Leukemia with L-Asparaginase — Preliminary Results on 84 Cases....Pages 263-278
The Place of the L-Asparaginase in the Treatment of Acute Leukemias....Pages 279-287
With Reference to Blastogenesis Inhibition by L-Asparaginase....Pages 288-295
Some Clinical Observations on the Treatment with L-Asparaginase of the Acute Leukemias....Pages 296-315
Clinical Trials of Asparaginase in Chemotherapy-Resistant Acute Leukemias....Pages 316-322
Use of Asparaginase in Conjunction with Cytosine Arabinoside in Acute Leukemia in Children....Pages 323-328
Clinical Studies with L-Asparaginase in Dermatomyositis....Pages 329-330
Blood Coagulation Changes under L-Asparaginase Therapy....Pages 331-341
The Hemostatic Defect Induced by Treatment with Asparaginase in Leukemia....Pages 342-343
Dysmetabolic and Neurological Complications in Leukemic Patients Treated with L-Asparaginase....Pages 344-349
A Summary of the Clinical Status of Asparaginase....Pages 350-354
Back Matter....Pages 355-356