Excitotoxins: Proceedings of an International Symposium held at The Wenner-Gren Center, Stockholm, August 26–27, 1982

Front Matter....Pages i-xii
Front Matter....Pages 1-1
Identification of Excitatory Amino Acid Pathways in the Mammalian Nervous System....Pages 3-18
Electrophysiological Actions of Kainate and Other Excitatory Amino Acids, and the Structure of Their Receptors....Pages 19-30
Two Types of Excitatory Amino Acid Responses in the Cat Caudate Nucleus....Pages 33-42
Recent Advances in the Pharmacology of Excitatory Amino Acids in the Mammalian Central Nervous System....Pages 43-54
Alteration by Kainate of Energy Stores and Neuronal-Glial Metabolism of Glutamate In Vitro ....Pages 55-65
Receptors for Excitotoxins....Pages 66-81
Excitotoxins: An Overview....Pages 82-96
Front Matter....Pages 97-97
Neuronal Degeneration after Intracerebral Injections of Excitotoxins. A Histological Analysis of Kainic Acid, Ibotenic Acid and Quinolinic Acid Lesions in the Rat Brain....Pages 99-111
Kainic Acid: Insights into Its Receptor-Mediated Neurotoxic Mechanisms....Pages 112-121
The Neurodegenerative Properties of Intracerebral Quinolinic Acid and its Structural Analog Cis-2,3-Piperidine Dicarboxylic Acid....Pages 122-137
Studies on Excitatory Amino Acid Receptors and Their Interactions and Regulation of Pre- and Postsynaptic Dopaminergic Mechanism in the Rat Telencephalon....Pages 138-156
Electrophysiological and Pharmacological Studies on Kainic Acid-Induced Neuronal Activation....Pages 157-169
An Analysis of Bioelectrical Phenomena Evoked by Microiontophoretically Applied Excitotoxic Amino-Acids in the Feline Spinal Cord....Pages 170-183
The Role of Seizures in Kainic Acid Induced Brain Damage....Pages 184-198
Excitatory Amino Acid Transmitters in Cerebellum and Optic Tectum....Pages 199-206
Mechanisms of Excitotoxins Examined in Organotypic Cultures of Rat Central Nervous System....Pages 207-219
Front Matter....Pages 221-221
Ibotenate as a Tool in Neurobiology. Studies on Dopaminergic and Cholecystokinin Immunoreactive Neurons after Ibotenate Induced Lesions....Pages 223-238
Characterization of Striatal Ibotenate Lesions and of 6-Hydroxydopamine Induced Nigral Lesions by Morphometric and Densitometric Approaches....Pages 239-250
Effect of Ibotenic Acid Stereotactically Injected into Striatum or Hippocampus on Local Blood Flow and Glucose Utilization in Rats....Pages 251-255
Synaptic Rearrangements in the Kainic Acid Model of Ammon’s Horn Sclerosis....Pages 256-270
Front Matter....Pages 221-221
On the Problem of Distant Lesions in Behavioual Studies Utilizing Kainic Acid....Pages 271-279
Kainic Acid Injections into the Rat Neostratum: Effects on Learning and Exploration....Pages 280-294
Effects of Neurotoxic Excitatory Amino Acids on Neuroendocrine Regulation....Pages 295-305
Front Matter....Pages 307-307
Adverse Reactions in Humans thought to be Related to Ingestion of Elevated Levels of Free Monosodium Glutamate (MSG)....Pages 309-330
Temporal Lobe Epilepsy, Excitotoxins and the Mechanism of Selective Neuronal Loss....Pages 331-342
Huntington’s Disease: Anti-Neurotoxic Therapeutic Strategies....Pages 343-353
Excitotoxicity in Aging and Dementia....Pages 354-362
Back Matter....Pages 363-363