Excitatory Amino Acids and Neuronal Plasticity

Front Matter....Pages i-x
Front Matter....Pages 1-1
Glutamate Receptors in Cultures of Mouse Hippocampus Studied with Fast Applications of Agonists, Modulators and Drugs....Pages 3-11
Measuring and Controlling the Extracellular Glycine Concentration at the NMDA Receptor Level....Pages 13-16
The Glycine Coagonist Site of the NMDA Receptor....Pages 17-26
The PCP Site of the NMDA Receptor Complex....Pages 27-34
Antagonists of NMDA-Activated Current in Cortical Neurons: Competition with Glycine and Blockade of Open Channels....Pages 35-43
Front Matter....Pages 47-47
Experiments with Kainate and Quisqualate Agonists and Antagonists in Relation to the Sub-Classification of ‘Non-NMDA’ Receptors....Pages 49-55
Homocysteic Acid as Transmitter Candidate in the Mammalian Brain and Excitatory Amino Acids in Epilepsy....Pages 57-63
Specific Quisqualate Receptor Ligand Blocks Both Kainate and Quisqualate Responses....Pages 65-71
Molecular Characterization, Ultrastructural Localization and Gene Cloning of the Chick Cerebellar Kainate Receptor....Pages 73-77
Intracellular Messengers Associated with Excitatory Amino Acid (EAA) Receptors....Pages 79-91
The Glycine Site on the NMDA Receptor: Pharmacology and Involvement in NMDA Receptor-Mediated Neurodegeneration....Pages 93-100
Evidence for Glutamate Receptor Subtypes from in Vivo Electrophysiology: Studies with HA-966, Quinoxalinediones and Philanthotoxin....Pages 101-108
Characterization of Membranal and Purified NMDA Receptors....Pages 109-114
Front Matter....Pages 115-115
Mechanisms Underlying Excitatory Amino Acid-Evoked Calcium Entry in Cultured Neurons from the Embryonic Rat Spinal Cord....Pages 117-124
Topographical Heterogeneity of Glutamate Agonist-Induced Calcium Increase in Hippocampus....Pages 125-133
Protection by Natural and Semisynthetic Gangliosides from Ca 2+ -Dependent Neurotoxicity Caused by Excitatory Amino Acid (EAA) Neurotransmitters....Pages 135-144
Front Matter....Pages 145-145
Periodic Inward Currents Triggered by NMDA in Immature CA3 Hippocampal Neurones....Pages 147-150
GABA Mediated Synaptic Events in Neonatal Rat CA3 Pyramidal Neurons in Vitro : Modulation by NMDA and Non-NMDA Receptors....Pages 151-159
Neural Networks and Synaptic Transmission in Immature Hippocampus....Pages 161-171
A Role of NMDA Receptors and Ca 2+ Influx in Synaptic Plasticity in the Developing Visual Cortex....Pages 173-180
Front Matter....Pages 145-145
Spontaneous and Evoked NMDA-Receptor Mediated Potentials in the Entorhinal Cortex of the Neonate Rat in Vitro ....Pages 181-186
Learning by Seeing: N-Methyl-D-Aspartate Receptors and Recognition Memory....Pages 187-196
The Role of the NMDA Receptor in the Development of the Frog Visual System....Pages 197-203
Front Matter....Pages 209-209
Excitatory Amino Acids, Growth Factors, and Calcium: A Teeter-Totter Model for Neural Plasticity and Degeneration....Pages 211-220
Trophic Effects of Excitatory Amino Acids in the Developing Nervous System....Pages 221-228
Mechanisms of Excitatory Amino Acid-Induced Stimulation of GABAergic Synaptic Activity in Cultures from the Rat Superior Colliculus....Pages 229-238
The Role of Taurine and Glutamate during Early Postnatal Cerebellar Development of Normal and Weaver Mutant Mice....Pages 239-244
Regulation of Neurite Outgrowth from Cerebellar Granule Cells in Culture: NMDA Receptors and Protein Kinase C....Pages 245-253
Regulation of GABA A Currents by Excitatory Amino Acids....Pages 255-263
Front Matter....Pages 267-267
Long-Term Potentiation in the Dentate Gyrus in Vivo is Associated with a Sustained Increase in Extracellular Glutamate....Pages 269-278
Long Term Potentiation is not Associated with a Sustained Enhanced Release of Glutamate in the Rat Hippocampus in Vivo and in Vitro ....Pages 279-289
Postsynaptic Mechanisms Involved in Long-Term Potentiation....Pages 291-299
Identifying and Localizing Protein Kinases Necessary for LTP....Pages 301-305
Delayed Onset of Potentiation in Neocortical EPSPs during Long-Term Potentiation (LTP) — A Postsynaptic Mechanism or Heterogeneous Synaptic Inputs ?....Pages 307-312
Local Circuit Connections Mediated by NMDA and Non-NMDA Receptors in Slices of Neocortex....Pages 313-321
Modulation of the Responsiveness of Cerebellar Purkinje Cells to Excitatory Amino Acids....Pages 323-329
Front Matter....Pages 331-331
The Role of Ependymin in Neuronal Plasticity and LTP....Pages 333-345
The Role of Protein Kinase C Substrate B-50 (GAP-43) in Neurotransmitter Release and Long-Term Potentiation....Pages 347-358
Different Mechanisms and Multiple Stages of LTP....Pages 359-368
Extracellular Proteases and S100 Protein in Long-Term Potentiation in the Dentate Gyrus of the Anaesthetized Rat....Pages 369-375
Front Matter....Pages 331-331
Modulation of the Induction of Long-Term Potentiation in the Hippocampus....Pages 377-386
Roles of Metabotropic and Ionotropic Glutamate Receptors in the Long-Term Potentiation of Hippocampal Mossy Fiber Synapses....Pages 387-394
Effects of a Neurotrophic Factor (FGF) on Development, Regeneration and Synaptic Plasticity of Central Neurons....Pages 395-399
Trans-Synaptophobia....Pages 401-403
Front Matter....Pages 405-405
Kindling, Prenatal Exposure to Ethanol and Postnatal Development Selectively Alter Reponses of Hippocampal Pyramidal Cells to NMDA....Pages 407-417
Sprouting of Mossy Fibers in the Hippocampus of Epileptic Human and Rat....Pages 419-424
Molecular Markers of Reactive Plasticity....Pages 425-432
Transplantation of Developing Hippocampal Neurons to Ischemic and Excitotoxic Lesions of the Adult Rat Hippocampus....Pages 433-443
Changes in Synaptic Transmission in the Kindled Hippocampus....Pages 445-450
NMDA Receptor Plasticity in the Kindling Model....Pages 451-459
NMDA-Receptors are Involved in Synaptic Plasticity Following Partial Denervation of CA1 Hippocampal Cells....Pages 461-469
Front Matter....Pages 473-473
Anoxia and NMDA Receptors....Pages 475-479
Modulation of ATP Sensitive K+ Channels: A Novel Strategy to Reduce the Deleterious Effects of Anoxia....Pages 481-489
Effects of Transient Forebrain Ischemia in Area CA1 of the Gerbil Hippocampus: An in Vitro Study....Pages 491-500
Acute Brain Injury, NMDA Receptors, and Hydrogen Ions: Observations in Cortical Cell Cultures....Pages 501-504
Mechanisms of Excitatory Amino Acid Neurotoxicity in Rat Brain Slices....Pages 505-518
Back Matter....Pages 523-530