Evolutionary Systems Biology

Front Matter....Pages i-x
Evolutionary Systems Biology: Historical and Philosophical Perspectives on an Emerging Synthesis....Pages 1-28
Metabolic Networks and Their Evolution....Pages 29-52
Organization Principles in Genetic Interaction Networks....Pages 53-78
Evolution of Regulatory Networks: Nematode Vulva Induction as an Example of Developmental Systems Drift....Pages 79-91
Life’s Attractors....Pages 93-119
Evolutionary Characteristics of Bacterial Two-Component Systems....Pages 121-137
Comparative Interaction Networks: Bridging Genotype to Phenotype....Pages 139-156
Evolution In Silico: From Network Structure to Bifurcation Theory....Pages 157-182
On the Search for Design Principles in Biological Systems....Pages 183-193
Toward a Theory of Multilevel Evolution: Long-Term Information Integration Shapes the Mutational Landscape and Enhances Evolvability....Pages 195-224
Evolutionary Principles Underlying Structure and Response Dynamics of Cellular Networks....Pages 225-247
Phenotypic Plasticity and Robustness: Evolutionary Stability Theory, Gene Expression Dynamics Model, and Laboratory Experiments....Pages 249-278
Genetic Redundancies and Their Evolutionary Maintenance....Pages 279-300
Evolution of Resource and Energy Management in Biologically Realistic Gene Regulatory Network Models....Pages 301-328
Reverse Ecology: From Systems to Environments and Back....Pages 329-345
Bacteria–Virus Coevolution....Pages 347-370
The Genotype–Phenotype Maps of Systems Biology and Quantitative Genetics: Distinct and Complementary....Pages 371-398
How Evolutionary Systems Biology Will Help Understand Adaptive Landscapes and Distributions of Mutational Effects....Pages 399-410
Building Synthetic Systems to Learn Nature’s Design Principles....Pages 411-429
The Robustness Continuum....Pages 431-452
Back Matter....Pages 453-455