Evolution-adjusted Tumor Pathophysiology:: The Novel Language of Tumor Biology

Front Matter....Pages i-x
Front Matter....Pages 1-1
Communication—Evolution—Pathophysiology: An Endogenous Conjunction—Instead of an Introduction....Pages 3-9
Front Matter....Pages 11-11
Applied Systems Biology for the Control of Metastatic Cancer: Therapeutic Top-Down Strategy for Targeting the Tumors’ Normativity....Pages 13-28
Targeting the Proangiogenic Network in Angiosarcomas: Biomodulatory Therapy....Pages 29-33
Long-Term Results of Combined Modularized, Immune-Modulatory, Angiostatic, and Antiinflammatory Therapy in Systemically Pre-Treated Multi-Systems Langerhans Cell Histiocytosis....Pages 35-45
Redirecting and Modulating Rationalizations of Tumor-Immanent Normative Functions in Castration-Resistant Prostate Cancer....Pages 47-66
Front Matter....Pages 67-67
Non-Hierarchically Organized Operations in Malignancies: Stromal Dysfunction Induces and Maintains Hematopoietic Malignancies....Pages 69-90
Biomodulatory Therapy Approaches in Renal Clear Cell Carcinoma: A Perspective....Pages 91-100
Proteome Analysis Identified the PPARγ Ligand 15d-PGJ2 as a Novel Drug Inhibiting Melanoma Progression and Interfering with Tumor-Stroma Interaction....Pages 101-141
Front Matter....Pages 143-143
The Philosophical Quest of a Cancer Cell: Redefining Existentialism....Pages 145-154
The Tumor’s Normativity: Normative Structures, Action Norms and Decision Maxims as Therapeutic Targets for Tumor Therapy....Pages 155-167
Criticizable Claims for the Validity of Communication Acts in Biological Systems: Therapeutic Implications in Cancer....Pages 169-187
Front Matter....Pages 189-189
Evolution Theory: Its Practical Relevance for Understanding Tumor Development and Specifying Tumor Therapy....Pages 191-238
Modularity, Subjectivity, Intersubjectivity and Normativity: Clinically Applicable Operative Benchmarks....Pages 239-247
Turning Upside Down the Mode of Science to Emphasize and Harness the Impact of Environmental Communication....Pages 249-257
Front Matter....Pages 259-259
Purposive-Rational Tumor Therapy: Exploiting the Tumor’s ‘Living World’ for Diversifying, Specifying and Personalizing Tumor Therapy....Pages 261-288
Including Rationalizations of Tumor-Associated Normative Notions in Pathophysiologic Considerations: Communication-Theoretical Implications....Pages 289-299
Front Matter....Pages 301-301
Bridging a Diagnostic and Therapeutic Gap: Selecting, Assessing and Categorizing, Tumor-associated Normative Notions....Pages 303-321
Personalizing Tumor Pathophysiology by Diagnosing Developmental Problems in Tumors with Imaging Techniques....Pages 323-341
Biologic Memory: Induction by Metronomically Administered Combined Modularized Therapy....Pages 343-361
Front Matter....Pages 363-363
Diversifying and Specifying Palliative Care for Patients with Metastatic Cancer by Therapeutic Implementation of Non-Normative Boundary Conditions....Pages 365-395
Front Matter....Pages 363-363
Targeting a Hallmark of Cancer: Simultaneous Inflammation and Tumor Control for Palliative Care in Metastatic Cancer....Pages 397-415
Front Matter....Pages 417-417
Combined Modularized Tumor Therapy—Tumor Biology—and Prognostic Factors: Bioengineering Tumor Response....Pages 419-429
Front Matter....Pages 431-431
The Subjectivity of Systems Objects as a Scientific Object....Pages 433-438
Back Matter....Pages 439-453