Everything You Wanted to Know About ADHD ...But Forgot You Wanted to Ask

Cover......Page 1
©......Page 2
Table of Contents......Page 3
CME Information......Page 5
1. Neurobiology, Circuitsand Genetics......Page 9
Deconstructing the Syndrome into DSM-IV Diagnostic Symptoms......Page 10
Important Brain Areas in Executive Function and Motor Control......Page 11
How are Core Symptoms of ADHD Linked to a Malfunctioning Prefrontal Cortex?......Page 12
Hypothetical Malfunctioning CSTC Loops in ADHD......Page 13
Assessing Sustained Attention and Problem Solving with the N-Back Test......Page 14
Assessing Selective Attention with the Stroop Task......Page 15
Impulsivity is Modulatedby the Orbital Frontal Cortex......Page 16
Motor Hyperactivity Is Modulated by the Prefrontal Motor Cortex......Page 17
Cognitive Dysfunction in ADHD Linked to Deficient Arousal......Page 18
Cognitive Dysfunction in ADHD Linked to Excessive Arousal, Stress and Comorbidity......Page 19
ADHD: Weak NE and DA Signals in Prefrontal Cortex......Page 20
Similar Symptoms in Different Disorders: Does It Matt er?......Page 21
Impact of Genetics in ADHD......Page 22
Nature vs. Nurture......Page 23
2. ADHD Across the Ages......Page 25
Synaptogenesis in Prefrontal Cortex and the Development of Executive Functions......Page 26
Impact of Development on ADHD......Page 27
Persistence of ADHD into Adulthood......Page 28
Evolution of ADHD Symptoms With Age......Page 29
Screening and Rating Scales: Children......Page 30
Screening and Rating Scales: Adults......Page 31
3. Comorbidities of ADHD......Page 33
Comorbidities in Children......Page 34
The Connection Between Sleep Problems and ADHD......Page 35
Comorbidities in Adults......Page 36
Bi-Directional Overlap Between ADHD and Substance Use Disorders......Page 37
What Should Be Treated First?......Page 38
4. The Treatment of ADHD......Page 39
ADHD in Children and Adolescents vs. Adults......Page 40
Treatment Choices Differ with the Age of the Patient......Page 41
Use of ADHD Medication by Agent and Formulation......Page 42
Medications Used in ADHD......Page 43
Specifi cs of ADHD Medications......Page 44
Slow-Dose Stimulants Amplify Tonic NE and DA Signals......Page 45
Pulsatile Stimulants Amplify Tonic and Phasic NE and DA Signals......Page 46
Atomoxetine in ADHD with Weak Prefrontal NE and DA Signals......Page 47
ADHD, Stress and Comorbidities......Page 48
Chronic Treatment with Atomoxetine in ADHD with Excessive Prefrontal NE and DA Signals......Page 49
Regulation of NE Pathways by Alpha 2A Agonist: Guanfacine ER and Clonidine......Page 50
Enhancing Arousal in the Prefrontal Cortex: How It Treats ADHD......Page 51
Desensitizing Arousal in the Prefrontal Cortex: How It Treats ADHD......Page 52
Psychosocial Therapies in Adults......Page 53
Summary......Page 55
Abbreviations......Page 56
Suggested Readings......Page 57
Rating Scales......Page 62
The SWAN* Rating Scale for ADHD......Page 69
Adults ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist......Page 71
CME Postt est......Page 73