Eukaryotic Cell Function and Growth: Regulation by Intracellular Cyclic Nucleotides

Front Matter....Pages i-xxii
Cell Fractionation by Centrifugation Methods....Pages 1-17
Binding of Ligands to Receptors: Theory....Pages 19-41
On the Modes of Regulation of Intracellular Cyclic AMP: Desensitization of Adenylyl Cyclases to Hormonal Stimulation and Compartmentalization of Cyclic AMP....Pages 43-66
The Interaction of Glucagon with Isolated Plasma Membranes of Rat Livers: The Relevancy of Measuring Binding Sites....Pages 67-96
Hormone Binding to Receptors: Vasopressin....Pages 97-111
Effects of Choleragen and Fluoride on Adenylate Cyclase....Pages 113-124
Stimulation of Adenylate Cyclase in the Thyroid....Pages 125-154
Guanylate Cyclase....Pages 155-193
Regulation of Cyclic AMP Phosphodiesterase Activity....Pages 195-202
Theoretical Simulation of the cAMP System....Pages 203-229
Control of Metabolic Processes by cAMP-Dependent Protein Phosphorylation....Pages 231-247
Cyclic AMP and Cyclic GMP Binding in Tissues....Pages 249-284
The Assay of Cyclic AMP in Biological Material....Pages 285-294
Determination of Cyclic GMP in Biological Material....Pages 295-311
Methods for the Study of Cyclic AMP Metabolism in Intact Cells....Pages 313-331
The Actions of Nucleotides on Adenylyl Cyclase Systems....Pages 333-357
Cyclic AMP Metabolism of Some Fibroblastic and Epithelial Cells In Vitro ....Pages 359-367
Metabolism of Cyclic GMP in Vascular Smooth Muscle, Leukocytes, and Lung....Pages 369-378
Cyclic Nucleotide Analogues....Pages 379-390
Microtubule Morphology....Pages 391-406
Cyclic AMP and Microtubules....Pages 407-434
Prostaglandins and Cyclic Nucleotides....Pages 435-465
Re-Examination of the Role of Cyclic AMP in the Actions of Glucagon and Epinephrine....Pages 467-495
The Role of Cyclic AMP in the Regulation of Glycogen Metabolism....Pages 497-532
Cyclic AMP and Pyruvate Dehydrogenase....Pages 533-548
Cyclic AMP and Protein Synthesis....Pages 549-566
Cyclic AMP and the Control of Lipolysis in Fat Cells of the Rat....Pages 567-576
Studies on the Permissive Effect of the Thyroid on fat Cells....Pages 577-590
Cyclic Nucleotides, Calcium and Ion Transport....Pages 591-607
Insulin Secretion — The Role and Mode of Action of Cyclic AMP....Pages 609-631
Effects of Cyclic AMP on B-Cell Function....Pages 633-638
Role of Cyclic Nucleotides in the Anterior Pituitary Gland....Pages 639-652
Mechanism of LH and FSH Action on the Testis....Pages 653-666
Possible Roles of Cyclic Nucleotides in the Regulation of Smooth Muscle Tonus....Pages 667-683
The Regulation of Thyroid Cell Metabolism....Pages 685-709
Behavior of Cultured Fibroblasts, The Cell Surface and Cyclic AMP....Pages 711-732
Chromatin Structure and the Role of Histone Phosphorylation in the Cell Cycle....Pages 733-745
Cyclic Nucleotides and Cell Adhesion....Pages 747-758
Cyclic AMP and Cancer....Pages 759-771
Cyclic Nucleotides and Cell Growth....Pages 773-793
Cyclic AMP and Myoblast Differentiation....Pages 795-806
Diseases Involving Cyclic AMP....Pages 807-835
Back Matter....Pages 837-838