Essential fatty acids and eicosanoids : invited papers from the fifth international congress

Essential fatty acids and eicosanoids: invited papers from the fifth international congress......Page 1
Preface......Page 6
Contents......Page 7
Introduction......Page 10
Biosynthesis of 22-Carbon Acids with Their First Double Bond at Position-4......Page 11
The Intracellular Movement of Polyunsaturated Fatty Acids......Page 12
References......Page 14
Introduction......Page 16
References......Page 19
Materials and Methods......Page 21
Results and Discussion......Page 22
References......Page 26
Materials and Methods......Page 27
Results......Page 28
Continuous Two-step Ethyl Esterification of DHA......Page 30
Summary......Page 31
References......Page 32
Materials and Methods......Page 33
Discussion......Page 34
References......Page 36
Results and Discussion......Page 38
References......Page 44
Results and Discussion......Page 45
References......Page 50
Antihypertensive Drugs......Page 51
Melatonin Receptor Agonist......Page 54
β3-Receptor Agonist......Page 55
Conclusion......Page 57
References......Page 58
Introduction......Page 59
References......Page 60
Environmental Effects on FAD2-1 Expression......Page 62
References......Page 64
Soybean Exports......Page 65
The Better Bean Initiative......Page 66
Conclusion......Page 67
Stereospecific Effects of Fat Digestion......Page 68
Effects of Stereospecific Structure of Dietary Glycerides on Chylomicron Clearing and Tissue Targeting......Page 70
Different Nutritional Effects of Fatty Acids Fed as Triglycerides or Phospholipids......Page 71
References......Page 72
How the Body Defends Itself Against ROS......Page 74
Is There a Solution to the n-3 Paradox?......Page 75
References......Page 77
What Is the Distribution of Radiolabeled ALA in Liver and Brain in Developing Rats?......Page 80
Does ALA Accumulate in Tissues Other Than Liver and Brain?......Page 82
ALA and Body Weight......Page 83
References......Page 84
Materials and Methods......Page 85
Results and Discussion......Page 87
References......Page 92
Introduction......Page 93
Experimental Methods......Page 94
Results......Page 95
References......Page 97
Hypothesis......Page 100
Experimental Evidence......Page 101
Discussion......Page 102
Summary......Page 105
Materials and Methods......Page 107
Results......Page 108
Discussion......Page 110
References......Page 112
Introduction......Page 114
References......Page 119
Discussion......Page 121
Summary......Page 122
Introduction......Page 124
Summary and Conclusions......Page 128
References......Page 129
Materials and Methods Introduction......Page 131
Results......Page 133
Discussion......Page 135
References......Page 138
Dietary Frying Oil Enhanced PGE Formation......Page 141
Phytochemicals......Page 142
Foods......Page 145
References......Page 148
The Extracellular Regulators of Prostaglandins in Reproductive Tissues......Page 150
Conclusion......Page 153
References......Page 154
Regulation of COX-2 Gene Expression......Page 155
Anti-Inflammatory Phytochemicals with Chemopreventive Potential......Page 157
Conclusion......Page 159
References......Page 160
Introduction......Page 164
Materials and Methods......Page 165
Results......Page 167
Discussion......Page 172
References......Page 175
5-Lipoxygenase......Page 178
12-Lipoxygenase......Page 180
Concluding Comments......Page 181
References......Page 182
13S-HODEÒSubstituted DAG Modulates Epidermal Signal Transduction......Page 183
Substituted DAG on EFAD-Induced Hyperproliferation......Page 185
Lipoxygenation of 20-Carbon PUFA by Epidermal 15- LOX......Page 186
Role of Cutaneous Monohydroxy Fatty Acids  13S- HODE and 15S- HETrE in Epidermal Skin Homeostasis......Page 187
Upregulation of Nuclear PKC and Mitogen- Activated Protein  MAP- Kinase During Hyperproliferation of Guinea Pig Epidermis: Modulation by 13S- HODE and 15S- HETrE......Page 188
Concluding Remarks......Page 189
References......Page 190
Introduction......Page 192
Vulnerable Plaques......Page 193
Oxidation......Page 195
Endothelial Dysfunction......Page 196
Diet and Genes......Page 198
Conclusion......Page 200
References......Page 201
The Antioxidant Paradox......Page 206
Dietary Oxidized Fatty Acids......Page 207
Postprandial Lipemia and CHD......Page 208
Summary......Page 209
References......Page 210
The Benefits of n-3 PUFA in Cardiovascular Disease......Page 213
Randomized Clinical Trials of n-3 PUFA in Secondary MI Prevention......Page 214
Vasoactive Agents......Page 216
Sudden Death......Page 217
References......Page 218
Introduction......Page 222
Abnormal Contractions in Hypertensive Vessels......Page 223
Modulation of by Dietary Constituents......Page 225
Summary......Page 226
Materials and Methods......Page 228
Results......Page 229
Discussion......Page 231
Summary......Page 233
References......Page 234
Introduction......Page 236
Conclusions......Page 237
Introduction......Page 239
References......Page 245
The Effect of Oxidized Frying Oil on OVA- Sensitized Mice......Page 252
The Effect of Vitamin E Supplementation on OVA- Sensitized Mice......Page 253
The Effect of Fish Oil Intakes on OVASensitized Mice......Page 254
References......Page 255
Introduction......Page 256
Anti-Inflammatory Actions of PBT: Inhibition of Lung Fibrosis......Page 257
Acknowledgments......Page 258
References......Page 259
Role of n-6 Polyunsaturated Fatty Acids in Hypertension......Page 260
Role of n-3 Polyunsaturated Fatty Acids in Hypertension......Page 261
Role of n-6/n-3 Polyunsaturated Fatty Acid Combinations in Hypertension......Page 262
References......Page 266
Materials and Methods......Page 270
Results......Page 271
Discussion......Page 272
References......Page 275
Materials and Methods......Page 276
Results......Page 278
Discussion......Page 279
References......Page 280
Introduction......Page 283
Results and Discussion......Page 284
Subjects and Methods......Page 287
Results......Page 288
Discussion......Page 290
References......Page 292
General......Page 294
Etiology: Factors Contributing to Scar Healing and Keloid Formations......Page 295
Histopathogenesis of Keloids......Page 296
References......Page 297
Materials and Methods......Page 299
Results and Discussion......Page 300
References......Page 304
Health Benefits of Metabolic Regulation......Page 305
Food Factors Regulating Metabolism......Page 306
Perspectives......Page 307
References......Page 308
Introduction......Page 309
References......Page 312
Introduction......Page 314
Acknowledgments......Page 316
References......Page 317
Metabolic Characteristics of DAG Compared with TAG......Page 318
Clinical Efficacy in Type 2 Diabetic Patients......Page 319
Physiologic Characteristics......Page 320
Human Long-Term Study in Japan......Page 321
Conclusion......Page 322
References......Page 323
Results......Page 325
Discussion......Page 326
References......Page 328
Subjects and Methods......Page 330
Results......Page 331
Discussion......Page 332
References......Page 335
Subjects and Methods......Page 337
Results......Page 338
Discussion......Page 340
References......Page 341
Comparison of Cholesterol-Lowering Effect of Phytosterol Dissolved in DAG vs. Phytosterol in TAG: Animal Study......Page 342
Comparison of Cholesterol-Lowering Effect of Phytosterol Dissolved in DAG vs. Phytosterol in TAG: Human Study......Page 343
Measurements of Body Weight, Visceral Fat Weight, Liver Weight, and Blood Sampling......Page 344
TAG: Human Study......Page 345
References......Page 346
Dietary CLA Influences Fatty Acid Metabolism......Page 348
References......Page 349
Experimental Studies......Page 352
Acknowledgments......Page 355
References......Page 356
The Comparative Effect of TAG-CLA and FFACLA on Tissue Weights, Lipid Metabolism, and Serum Metabolites......Page 357
The t10,c12-Isomer of CLA Reduces TAG Mass in the Liver, Serum, and Abdominal Adipose Tissue......Page 358
Effect of CLA on Energy Metabolism in OLETF Rats......Page 359
References......Page 360
Experimental Procedures......Page 362
Results......Page 364
Discussion......Page 366
Acknowledgments......Page 367
References......Page 368