ESMO Handbook of Cancer in the Senior Patient (European Society for Medical Oncology Handbooks)

Contents......Page 6
Preface......Page 12
Contributors......Page 14
Biology of Aging and Changes in Organ Function......Page 18
Changes in Cognition......Page 19
Clinical Aspects......Page 20
Further Reading......Page 24
Population Demographics......Page 25
Cancer Demographics......Page 26
Society-Related Problems......Page 28
Further Reading......Page 29
Introduction......Page 30
Short Screening Tools......Page 32
MGA Packages......Page 36
Further Reading......Page 37
Frailty in the Elderly......Page 39
The Impact of Frailty on Cancer......Page 42
Assessment of Frailty......Page 44
Further Reading......Page 45
Indications for Surgery......Page 46
Patients Selection......Page 47
Outcomes......Page 49
Palliation......Page 50
Conclusion......Page 51
Further Reading......Page 52
Indications for Radiotherapy in the Elderly......Page 53
Side Effects of Radiotherapy in the Elderly ( Acute and Late)......Page 54
Efficacy and Outcome of Radiotherapy in the Aging......Page 57
Curative Setting: Combinations of Chemotherapy and Radiotherapy......Page 59
Selection Criteria for Radiotherapy in the Elderly......Page 60
Conclusions......Page 61
Further Reading......Page 62
Breast Cancer......Page 63
Prostate Cancer......Page 67
Further Reading......Page 73
Chemotherapy in Senior Adults......Page 74
Targeted Therapies in Senior Adults......Page 78
Further Reading......Page 81
Diagnosis and Prognosis......Page 83
Treatment......Page 85
Further Reading......Page 87
Diagnosis and Classification of Myeloproliferative Disorders......Page 89
Treatment Strategies of MPD in the Senior Patient......Page 93
Future Outlook......Page 97
Further Reading......Page 98
Classification and Risk Scoring in MDS......Page 99
Age-Adjusted Models and Assessment in Elderly MDS Patients......Page 102
Treatment Options in Elderly MDS Patients......Page 103
Further Reading......Page 107
Early Breast Cancer......Page 109
Metastatic Breast Cancer......Page 112
Further Reading......Page 114
Early Non–Small Cell Lung Cancer in the Elderly......Page 115
Advanced Non–Small Cell Lung Cancer in the Elderly......Page 118
Small Cell Lung Cancer in the Elderly......Page 123
Conclusion......Page 124
Further Reading......Page 125
Adjuvant Chemotherapy......Page 126
Metastatic Disease......Page 128
Further Reading......Page 130
Introduction and General Background......Page 131
Treatment of Localized Prostate Cancer in Senior Adult Patients......Page 133
Treatment of Metastatic Prostate Cancer in Senior Adult Patients......Page 134
Conclusion......Page 135
Acknowledgments......Page 136
Further Reading......Page 137
Pathology......Page 138
Imaging, Cystoscopy, and Urinary Cytopathology......Page 139
Staging......Page 140
Surgical Treatment......Page 141
Radiotherapy......Page 142
Prognosis of BC......Page 143
Further Reading......Page 144
Cervical Cancer......Page 145
Uterine Cancer......Page 149
Special Types of Endometrial Malignancy......Page 150
Vaginal Cancer......Page 151
Vulvar Cancer......Page 154
Ovarian Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cancer......Page 156
Further Reading......Page 159
Surgery......Page 160
Radiotherapy......Page 161
Chemotherapy......Page 162
Conclusion......Page 163
Further Reading......Page 164
Introduction......Page 165
Systemic Therapy of Metastatic Renal Cell Carcinoma in the Senior Cancer Patient......Page 166
Patient-Focused Approach......Page 170
Further Reading......Page 173
Depression......Page 174
Anxiety......Page 178
Further Reading......Page 181
Introduction......Page 182
Attention......Page 184
Diagnosis......Page 185
Time......Page 186
Caution......Page 187
Further Reading......Page 188
Introduction......Page 189
The Assessment of Age......Page 190
Polypharmacy......Page 192
Management of the Caregiver......Page 193
Function of the Team......Page 195
Further Reading......Page 197
A......Page 198
C......Page 199
D......Page 201
F......Page 202
H......Page 203
L......Page 204
N......Page 205
P......Page 206
R......Page 207
S......Page 208
U......Page 209
X......Page 210