Epstein-Barr Virus and Human Disease • 1988

Front Matter....Pages i-xxvii
Front Matter....Pages 1-1
Epstein-Barr Virus Transformation of B Lymphocytes: Molecular Pathogenesis....Pages 3-15
Role of The Zebra Protein in the Switch Between Epstein-Barr Virus Latency and Replication....Pages 17-35
DNA:EBMA-1 Interactions and Latency of Epstein-Barr Virus....Pages 37-42
The EBV DR Enhancer Contains two Functionally Different Domains: A and B.....Pages 43-47
Identification of the Gene Product Encoded by the Not l Repeats of the EBV Genome....Pages 49-53
Effect of the BZLF1 Transactivator on Different Classes of EBV Promoters....Pages 55-60
EBNA Expression and CpG Methylation of Viral DNA in EBV Associated Tumours....Pages 61-62
Transcription and Protein Expression Pattern of EBV in Freshly Infected Lymphoid Cells....Pages 63-67
Characterization of a cDNA of Epstein-Barr Virus DNase Gene....Pages 69-74
The 5’Flanking Region of the Gene for EBNA2 Contains a Cell Type Specific cis -Acting Regulatory Element that Activates Transcription in Transfected B-Cells....Pages 75-78
Establishment and Characterization of a Tumor Cell Line from Nasopharyngeal Carcinoma Tissue....Pages 79-82
Front Matter....Pages 83-83
EBV DNA Structure and Expression in EBV-Induced Proliferations....Pages 85-97
The Role of Differentially Expressed EB-Viral and Cellular Genes for Development of Virus-Related Tumors and Possibilities of the Control of These Diseases....Pages 99-103
Detection of Proteins Binding to the EBV EBNA-2 Promoter....Pages 105-112
Anti EBNA-1 Protein Induced with TPA....Pages 113-118
Characterization of the EBV Alkaline Exonuclease Expressed in a Recombinant Prokaryotic System....Pages 119-124
Immunocytochemistry of EBV Envelope Glycoproteins on Freeze-Fractured Nuclear Membranes of Virus Producer Cells....Pages 125-130
Detection of a Transformation-Incompetent Epstein-Barr Virus Genotype in a Seronegative Host....Pages 131-135
Propagation and Cytogenetic Analysis of NPC Biopsies in Nude Mice: Evidence for a Translocation in Chromosome #8 at 8q 2 4 which is the Localization of the c-myc Gene....Pages 137-140
Epstein-Barr Virus Gene Expression in Lymphomas Induced by the Virus in the Cottontop Tamarin....Pages 141-144
Front Matter....Pages 83-83
The DNA Demethylating Agent 5-Azacytidine Induces the Expression of EBNA 2–6 and LMP in Burkitt Lymphoma Lines....Pages 145-148
Epstein-Barr Virus mRNA Expression in Biopsies of Lymphoma Induced by the Virus in the Cottontop Tamarin....Pages 149-153
Establishment of Salivary Gland Epithelial Cell Lines from Patients with Sjogren’s Syndrome and Normal Individual....Pages 155-161
The Transforming Activity of a Nasopharyngeal Carcinoma-Derived Epstein-Barr Virus Isolate....Pages 163-167
Front Matter....Pages 169-169
Immune Control Mechanisms over EBV Infection....Pages 171-178
Epstein-Barr Virus Infection and Immunoregulation....Pages 179-187
Helper T Lymphocyte Proliferation is Stimulated by the Presence of EBV-Carrying B Lymphocytes....Pages 189-193
Role of the Recognition of Virion Antigens in the T-Cell Mediated Inhibition of EBV-Induced B-Cell Transformation....Pages 195-200
An Analysis of the Cytotoxic T-Cell Response of A- and B-Type EB Virus....Pages 201-206
The Immune Response to Glycine-Rich Sequences of Epstein-Barr Nuclear Antigen-1 (EBNA-1) in Autoimmunity: B and T Cell Epitopes....Pages 207-212
Cytotoxic Tumor Infiltrating Lymphocytes in Nasopharyngeal Carcinoma....Pages 213-218
Generation of Cytotoxic T Cells Against EBV Infected B Lymphocytes....Pages 219-222
T Cell Response to Peptides Encompassing a 5 Amino Acid Sequence Shared by the HLA DW4 DR Beta 1 Chain and the Epstein Barr Virus Glycoprotein GP110....Pages 223-226
Growth Stimulation and Immunoglobulin (Ig) Secretion in Epstein-Barr Virus (Ebv)-Infected B Cells by Interleukin 6 (IL-6)....Pages 227-229
Presence of EBV Infected Cells in the Bone Marrow from Transplant Donors....Pages 231-235
Front Matter....Pages 237-237
Clinical Syndromes Associated with Epstein-Barr Virus....Pages 239-250
The Natural History and Treatment of EBV Infections and Their Nonmalignant Complications....Pages 251-260
Epstein-Barr Virus Polymorphic Diffuse Lymphoma Associated with Leukemia and with Congenital Immunodeficiencies....Pages 261-266
EB-Viral Expression Depends on the Differentiated Status of Epithelial Cells in Oral Hairy L eukoplakia....Pages 267-270
EBV-Associated Lymphoproliferative Disorders in a Large Transplant Population....Pages 271-275
Front Matter....Pages 237-237
EBV Associated Head and Neck Tumours and Thymic Lesions....Pages 277-280
Expression of EBV in the Nasopharyngeal Carcinoma-Derived Nude Mouse Tumour, C15....Pages 281-286
Killer Cell Defect and Lack or Loss of Antibodies to Epstein-Barr Virus Glycoproteins in Chronic Active EBV....Pages 287-291
Characterization of Cell Types and EBV Gene Expression in Lymphoproliferative Diseases (LPD) of Patients Receiving Bone Marrow Transplants (BMT) after T-Cell Depletion....Pages 293-296
Epstein-Barr (EBV) Viral DNA in Tissues of Immunocompetent and Immunodeficient Children....Pages 297-301
Different Cell Susceptibility to Epstein-Barr Virus Infection in a Patient with X-Linked Lymphoproliferative Syndrome....Pages 303-306
Front Matter....Pages 307-307
Detection of EBV Specific IgA Antibodies to EA, MA and EBNA-1 Recombinant Proteins in NPC Patients and Controls....Pages 309-313
Challenges in the Treatment of EBV-Associated Diseases: New Approaches....Pages 315-327
Epstein-Barr Virus Replication and Gene Expression in Oral “Hairy” Leukoplakia....Pages 329-331
Changes in virus-host genome relationship in two sublines of the same Burkitt’s lymphoma....Pages 333-339
Molecular Weight Variation of EBNAs as a Means to Identify Different Epstein-Barr Virus Isolates (EBNotyping)....Pages 341-347
Cell-Mediated Responses to Epstein-Barr Virus Lytic Antigens....Pages 349-353
Successful Therapy for EBV Associated B Cell Lymphoproliferative Disorders in Immunodeficiency Using Alpha Interferon and Intravenous Immunoglobulin....Pages 355-360
Serological Correlation of HHV-6 and EBV Infections in Infectious Mononucleosis....Pages 361-367
Natural Epstein-Barr Virus Isolates from Southern China and California Differ in the Bam Hl I Region....Pages 369-374
Antibodies Against EBNA-1 Derived Synthetic Peptide in Various Patient Groups....Pages 375-378
Nasopharyngeal Carcinoma (NPC): The Influence of Different Types of Interferon (IFN) on Peripheral Blood Lymphocytes....Pages 379-383
Early Diagnosis of Nasopharyngeal Carcinoma: A Multi-Pronged Approach....Pages 385-389
Front Matter....Pages 391-391
Cellular Receptors for Epstein-Barr Virus....Pages 393-403
The Post-Infectious Chronic Fatigue Syndrome....Pages 405-438
Front Matter....Pages 391-391
Post Viral Chronic Fatigue Syndrome: Persistence of Epstein-Barr Virus DNA in Muscle....Pages 439-444
The Post-Infectious Chronic Fatigue Syndrome: Cell Surface Expression of LFA-1 And ICAM-1....Pages 445-447
Front Matter....Pages 449-449
Epstein-Barr Virus (EBV)-Induced Transformation and EBV Genome Reorganization in Lymphoblastoid Cell Lines Established from Patients with AIDS Following Enhancement with Chemical Carcinogens....Pages 451-460
Human Herpesvirus-6 (Human B-Lymphotrophic Virus)....Pages 461-472
Interactions of Epstein-Barr Virus with Human Retroviruses....Pages 473-480
An Environmental Plant Factor Enhancing EBV-Specific Events in East Africa: Reduction of Killer T-Cell Function and Its Protection by Hot Spring Water....Pages 481-484
Epstein-Barr Virus Antigens and Genome in Lymph Nodes from Patients with Persistent Generalized Lymphadenopathy (PGL)....Pages 485-488
Interaction of HBLV (HHV-6) With EBV and HIV....Pages 489-494
Enhanced SV40 Immortalization of Primary Human Epidermal Cells Following Phorbol Ester Dependent EBV Transformation....Pages 495-500
Food Extracts from High Risk Areas for NPC Induce an EBV Early Promoter....Pages 501-504
Back Matter....Pages 505-522