Epidemiological Concepts in Clinical Pharmacology

Front Matter....Pages I-XII
Opening Remarks....Pages 1-1
The Thalidomide Hypothesis: How It Was Found and Tested....Pages 3-10
Reasons for the Successes and Failures of Specific Models in Drug Epidemiology....Pages 11-22
Methodological Concepts: What Could We Know and What Should We Know in Drug Epidemiology?....Pages 23-33
The Design of Case-Control Studies....Pages 34-42
Methodological Evaluation of Studies in Drug Epidemiology....Pages 43-49
Problems with International Evaluation of Drug Risks....Pages 50-56
Drug Utilization Studies — an Instrument in Drug Research....Pages 57-72
Observational Cohort Study in General Practice: Differences and Equivalences Among Analgesics for Treatment of Colic Pain....Pages 73-86
Oxprenolol in Myocardial Infarction Survivors: Brief Review of the European Infarction Study Results in the Light of Other Beta-Blocker Post Infarction Trials....Pages 87-99
The Epidemiological Evaluation of Major Upper Gastrointestinal Bleeding in Relation to Aspirin Use....Pages 100-104
The Role of Pharmacogenetics in Drug Epidemiology....Pages 105-118
Possibilities and Limitations of a Modified Spontaneous ADR Monitoring System Available to Practitioners in Germany....Pages 119-124
Prescription of Psychotropic Drugs in Germany....Pages 125-137
The Benefit-Risk Evaluation of Drugs by Health Authorities in the Federal Republic of Germany....Pages 138-142
Postmarketing Surveillance of Drugs: Visions of the Future....Pages 143-147
Closing Remarks....Pages 148-148