Enzymology and Molecular Biology of Carbonyl Metabolism 3

Front Matter....Pages i-ix
Aldehyde Dehydrogenases: What can be Learned from a Baker’s Dozen Sequences?....Pages 1-8
Rat Class 3 Aldehyde Dehydrogenase: Crystals and Preliminary Analysis....Pages 9-11
Probing the Active Site of Aldehyde Dehydrogenase by Site Directed Mutagenesis....Pages 13-17
Localization of Cysteine 302 at the Active Site of Aldehyde Dehydrogenase....Pages 19-30
PH Effects on Cytoplasmic Aldehyde Dehydrogenase from Sheep Liver....Pages 31-41
Biochemical, Immunological, and Molecular Characterization of a “High KM” Aldehyde Dehydrogenase....Pages 43-52
Purification and Properties of Baboon Corneal Aldehyde Dehydrogenase: Proposed UVR Protective Role....Pages 53-60
A Polymorphism in the Rat Liver Mitochondrial ALDH2 Gene is Associated with Alcohol Drinking Behavior....Pages 61-65
Aldehydic Products of Lipid Peroxidation: Substrates or Inhibitors of Hepatic Aldehyde Dehydrogenase?....Pages 67-73
Metabolism of 4-Hydroxynonenal in Hepatoma Cell Lines....Pages 75-84
Role of Aldehyde Dehydrogenase (ALDH) in the Detoxication of Cyclophosphamide (CP) in Rat Embryos....Pages 85-95
Human and Mouse Hepatic Aldehyde Dehydrogenases Important in the Biotransformation of Cyclophosphamide and the Retinoids....Pages 97-104
A Paradigm for Aldehyde Oxidation: Histidinol Dehydrogenase....Pages 105-112
Structural Studies of Pig Lens Aldose Reductase: Reversible Dimerization of the Enzyme....Pages 113-118
cDNA Cloning and Expression of Human Aldose Reductase....Pages 119-127
 In Vitro Expression of Human Placental Aldose Reductase in Escherichia Coli ....Pages 129-138
Osmotic Stress Induces Aldose Reductase in Glomerular Endothelial Cells....Pages 139-152
Purification of Aldose and Aldehyde Reductases from Dog Kidney....Pages 153-163
Study on Dihydrodiol Dehydrogenase (I) Molecular Forms of the Enzyme and the Presence of a Dihydrodiol Specific Enzyme in Bovine Liver Cytosol....Pages 165-175
Study on Dihydrodiol Dehydrogenase (II) Modulation of Dihydrodiol Dehydrogenase Activity by Biological Disulfides....Pages 177-185
Distribution of Dimeric Dihydrodiol Dehydrogenase in Pig Tissues and its Role in Carbonyl Metabolism....Pages 187-196
Inhibition of Aldehyde Reductase by Carboxylic Acids....Pages 197-204
Reactivity of Enzyme Modification Reagents with Aldose Reductase and Aldehyde Reductase....Pages 205-216
A Kinetic Perspective on the Peculiarity of Aldose Reductase....Pages 217-228
Best-Fit Analysis of Kinetic Scheme for the Stepwise Reduction of the “Diketo” Group of 6-Pyruvoyl Tetrahydropterin by Sepiapterin Reductase....Pages 229-239
Catalysis by Yeast Alcohol Dehydrogenase....Pages 241-251
Alcohol Dehydrogenase Gene Expression and Cloning of the Mouse χ-Like ADH....Pages 253-262
Role of Alcohol Dehydrogenase Polymorphism in Ethanol Metabolism and Alcohol-Related Diseases....Pages 263-270
Characterization of Human Alcohol Dehydrogenases Containing Substitutions at Amino Acids 47 and 51....Pages 271-275
Endocrine Regulation and Methylation Patterns of Rat Class I Alcohol Dehydrogenase in Liver and Kidney....Pages 277-284
Mammalian Class II Alcohol Dehydrogenase: Species and Class Comparisons at Genomic and Protein Levels....Pages 285-292
The Activation of Alcohols by Liver Alcohol Dehydrogenase: Dependence of Inhibition Upon the pK a Lowering Effect....Pages 293-304
Glutathione-Dependent Formaldehyde Dehydrogenase (EC 1.2.1.1): Evidence for the Identity with Class III Alcohol Dehydrogenase....Pages 305-313
Kinetics and Mechanism of Methanol and Formaldehyde Interconversion and Formaldehyde Oxidation Catalyzed by Liver Alcohol Dehydrogenase....Pages 315-325
Novel Substrates and Inhibitors of Human Liver Sorbitol Dehydrogenase....Pages 327-336
Comparison of the Primary Structures of NAD(P)-Dependent Bacterial Alcohol Dehydrogenases....Pages 337-345
Back Matter....Pages 347-359