Enzymology and Molecular Biology of Carbonyl Metabolism 4

Front Matter....Pages i-xiv
Aldehyde Dehydrogenases — The 1992 Perspective....Pages 1-4
Metabolic Role of Aldehyde Dehydrogenase....Pages 5-15
Effects of Aldehyde Products of Lipid Peroxidation on the Activity of Aldehyde Metabolizing Enzymes in Hepatomas....Pages 17-25
Metabolic Interactions of 4-Hydroxynonenal, Acetaldehyde and Glutathione in Isolated Liver Mitochondria....Pages 27-36
Biological Role of Human Cytosolic Aldehyde Dehygrogenase 1: Hormonal Response, Retinal Oxidation and Implication in Testicular Feminization....Pages 37-44
Human Cytosolic Aldehyde Dehydrogenase in Androgen Insensitivity Syndrome....Pages 45-50
The use of Immortalized Mouse L1210/OAP Cells Established in Culture to Study the Major Class 1 Aldehyde Dehydrogenase-Catalyzed Oxidation of Aldehydes in Intact Cells....Pages 51-62
Enhanced Transcription of the Cytosolic ALDH Gene in Cyclophosphamide Resistant Human Carcinoma Cells....Pages 63-72
Attempts to Increase the Expression of Rat Liver Mitochondrial Aldehyde Dehydrogenase in E. coli by Altering the mRNA....Pages 73-79
Preliminary Characterization of the Rat Class 3 Aldehyde Dehydrogenase Gene....Pages 81-86
Human High-K m , Aldehyde Dehydrogenase (ALDH3): Molecular, Kinetic and Structural Features....Pages 87-98
Overexpression or Polycyclic Aromatic Hydrocarbon-Mediated Induction of an Apparently Novel Class 3 Aldehyde Dehydrogenase in Human Breast Adenocarcinoma Cells and its Relationship to Oxazaphosphorine-Specific Acquired Resistance....Pages 99-113
Tumor-Associated Aldehyde Dehydrogenase (ALDH3): Expression in Diffrent Human Tumor Cell Lines with and without Treatment with 3-Methylcholanthrene....Pages 115-122
Sexual Differentiation in the Induction of the Class 3 Aldehyde Dehydrogenase....Pages 123-129
Mouse Class 3 Aldehyde Dehydrogenases: Positive and Negative Regulation of Gene Expression....Pages 131-139
Human Stomach Aldehyde Dehydrogenase, ALDH3....Pages 141-152
Bovine Corneal Aldehyde Dehydrogenases: Evidence for Multiple Gene Products (ALDH3 and ALDHX)....Pages 153-157
Carbonyl-Metabolizing Enzymes and Their Relatives Recruited as Structural Proteins in the Eye Lens....Pages 159-168
Members of the ALDH Gene Family are Lens and Corneal Crystallins....Pages 169-179
Retinoic Acid Synthesis in the Developing Retina....Pages 181-190
Human Liver High Km Aldehyde Dehydrogenase (ALDH4): Properties and Structural Relationship to the Glutamic γ-Semialdehyde Dehydrogenase....Pages 191-197
Effect of Some Compounds Related to Disulfiram on Mitochondrial Aldehyde Dehydrogenase in Vitro and in Vivo ....Pages 199-209
Photoaffinity Labeling of Aldehyde Dehydrogenase from Horse Liver by P 1 -N 6 -(4-Azidophenylethyl)adenosine-P 2 -[4-(3-Azidopyridinio)Butyl] Diphosphate....Pages 211-219
Aldehyde Dehydrogenase: Aldehyde Dehydrogenation and Ester Hydrolysis....Pages 221-231
Is the Single Site Binding Model for Aldehyde Dehydrogenase an Oversimplification? The One-Site, Two-Site Debate Revisited....Pages 233-244
Crystallization and Preliminary X-ray Analysis of Bovine Mitochondrial Aldehyde Dehydrogenase and Human Glutathione-Dependent Formaldehyde Dehydrogenase....Pages 245-250
The Aldo-Keto Reductases: an Overview....Pages 251-257
Location of an Essential Arginine Residue in the Primary Structure of Pig Aldose Reductase....Pages 259-265
CYS 298 is Responsible for Reversible Thiol-Induced Variation in Aldose Reductase Activity....Pages 267-277
Substrate Specificity of Reduced and Oxidized Forms of Human Aldose Reductase....Pages 279-288
Kinetic Alteration of Human Aldose Reductase by Mutagenesis of Cysteine Residues....Pages 289-300
Inhibition of Aldose Reductase By (2, 6-Dimethylphenylsulphonyl)Nitromethane: Possible Implications for the Nature of an Inhibitor Binding Site and A Cause of Biphasic Kinetics....Pages 301-311
Sepiapterin Reductase and ALR2 (“Aldose Reductase”) from Bovine Brain....Pages 313-324
Polymorphisms of the Aldose Reductase Locus (ALR2) and Susceptibility to Diabetic Microvascular Complications....Pages 325-332
Polycyclic Aromatic Hydrocarbons and Phenolic Antioxidants do not Significantly Induce Carbonyl Reductase in Human Cell Lines....Pages 333-337
The Purification and Properties of a Novel Carbonyl Reducing Enzyme from Mouse Liver Microsomes....Pages 339-350
Properties and Stereoselectivity of Carbonyl Reductases Involved in the Ketone Reduction of Warfarin and Analogues....Pages 351-360
Activation of Pulmonary Carbonyl Reductase by Aromatic Amines and Pyridine Ring-Containing Compounds....Pages 361-370
Unique Dihydrodiol Specific Dehydrogenase of Bovine Liver: Inhibition Studies and Comparison with Aldo/Keto Reductase....Pages 371-377
Carbonyl Reduction by 3α-HSD from Comamonas Testosteroni — New Properties and its Relationship to the SCAD Family....Pages 379-390
Substrate Specificity of Alcohol Dehydrogenases....Pages 391-400
The Influence of pH on the Substrate Specificity and Stereoselectivity of Alcohol Dehydrogenase from Horse Liver....Pages 401-410
The Catalytic Specificity of Liver Alcohol Dehydrogenase: Vitamin A Alcohol and Vitamin A Aldehyde Activities....Pages 411-418
A Synthetic Approach to Analysis of the Structural Zinc Site of Alcohol Dehydrogenase....Pages 419-428
Kinetics of A Glycine for Arg-47 Human Alcohol Dehydrogenase Mutant Can be Explained by Lys-228 Recruitment into the Pyrophosphate Binding Site....Pages 429-437
Site-Directed Mutagenesis of Mammalian Alcohol and Sorbitol Dehydrogenases Map Functional Differences within the Enzyme Family....Pages 439-450
Horse Liver Alcohol Dehydrogenase — S — Isozyme: Confirmation of the Primary Structure by Protein Sequencing and Ion Spray Mass Spectrometry....Pages 451-455
Mixed Substrate Experiments with Class III (χ) Alcohol Dehydrogenases from Human and Pig Liver and Stomach....Pages 457-464
Glutathione-Dependent Formaldehyde Dehydrogenase/Class III Alcohol Dehydrogenase: Further Characterization of the Rat Liver Enzyme....Pages 465-474
Class IV Alcohol Dehydrogenase: Structure and Function....Pages 475-480
The Oxidation of Aldehydes by Horse Liver Alcohol Dehydrogenase....Pages 481-491
Effect of Glycation Upon Activity of Liver Alcohol Dehydrogenase....Pages 493-500
Kinetically Specific Spin-Label Substrates of Liver Alcohol Dehydrogenase and of Liver Aldehyde Dehydrogenase....Pages 501-512
Fluorescence Studies of Ternary Complexes of Liver Alcohol Dehydrogenase....Pages 513-521
Evolutionary Relationships of Branched Chain and Non-specific Alcohol and Aldehyde Dehydrogenases....Pages 523-531
Enzyme and Isozyme Developments within the Medium-Chain Alcohol Dehydrogenase Family....Pages 533-544
Tissue Distribution of Alcohol and Sorbitol Dehydrogenase mRNAs....Pages 545-553
The Role of Alcohol and Aldehyde Dehydrogenases In Alcohol-Related Diseases: Clinical Studies of Molecular Markers....Pages 555-560
Regulation of the Human Alcohol Dehydrogenase Genes ADH1 , ADH2 and ADH3 : Differences in Cis -Acting Sequences At CTF/NF-I Sites....Pages 561-570
DNA Elements Mediating Retinoid and Thyroid Hormone Regulation of Alcohol Dehydrogenase Gene Expression....Pages 571-580
Modulation of Hepatic and Renal Alcohol Dehydrogenase Activity and mRNA By Steroid Hormones in Vivo....Pages 581-589
Alcohol- and Aldehyde-Dehydrogenase: Modulation By Biogenic Amine Metabolites, Neuropeptides and Psychoactive Agents....Pages 591-603
Microbial Alcohol, Aldehyde and Formate Ester Oxidoreductases....Pages 605-620
Carbonyl Metabolising Enzymes in Alkane-Grown Microorganisms....Pages 621-630
Back Matter....Pages 631-637