Enzyme Kinetics and Mechanism - Part C: Intermediates, Stereochemistry, and Rate Studies

Content: 
Contribution to volume 87
Pages ix-x

Preface
Page xi
Daniel L. Purich

Volumes in series
Pages xiii,xv-xxi

[1] Criteria for evaluating the catalytic competence of enzyme-substrate covalent compounds Original Research Article
Pages 3-20
Daniel L. Purich

[2] Galactose-1-phosphate uridylyltransferase: Detection, isolation, and characterization of the uridylyl enzyme Original Research Article
Pages 20-36
Perry A. Frey, Lee-Jun Wong, Kwan-Fu Sheu, Sue-Lein Yang

[3] The trimethylacetyl-transglutaminase complex Original Research Article
Pages 36-42
J.E. Folk

[4] Intermediates in the phosphoglycerate mutase and bisphosphoglycerate synthase reactions Original Research Article
Pages 42-51
Zelda B. Rose

[5] Covalent chemistry of pyruvate, orthophosphate dikinase Original Research Article
Pages 51-66
Neil H. Goss, Harland G. Wood

[6] Preparation and properties of covalent compounds and intermediates of serine proteases Original Research Article
Pages 66-76
R.J. Coll, P.D. Compton, A.L. Fink

[7] Covalent reaction of substrates and antimetabolites with formylglycinamide ribonucleotide amidotransferase Original Research Article
Pages 76-84
John M. Buchanan

[8] Enzymology of enol intermediates Original Research Article
Pages 84-97
Irwin A. Rose

[9] Stereospecificities of the pyridine nucleotide-linked enzymes Original Research Article
Pages 101-126
Kwan-sa You

[10] Preparation, analysis, and biochemical applications of chiral methyl groups Original Research Article
Pages 126-159
Heinz G. Floss

[11] Preparation of chromium(III) and cobalt(III) nucleotides as chirality probes and inhibitors Original Research Article
Pages 159-179
W. Wallace Cleland

[12] NMR and EPR studies of chromium and cobalt nucleotides and their interactions with enzymes Original Research Article
Pages 180-197
Joseph J. Villafranca

[13] Stereochemistry of enzymic phosphoryl and nucleotidyl transfer Original Research Article
Pages 197-212
Fritz Eckstein, Paul J. Romaniuk, Bernard A. Connolly

[14] Stereochemistry of selected phosphotransferases and nucleotidyltransferases Original Research Article
Pages 213-235
Perry A. Frey, John P. Richard, Hsu-Tso Ho, Richard S. Brody, R. Douglas Sammons, Kwan-Fu Sheu

[15] Use of 31P(18O), 31P(17O), and 17O NMR methods to study enzyme mechanisms involving phosphorus Original Research Article
Pages 235-279
Ming-Daw Tsai

[16] Chiral [16O, 17O, 18O] phosphoric monoesters as stereochemical probes of phosphotransferases Original Research Article
Pages 279-301
Stephen L. Buchwald, David E. Hansen, Annemarie Hassett, Jeremy R. Knowles

[17] The stereochemical course of nucleoside triphosphatase reactions Original Research Article
Pages 301-316
Martin R. Webb

[18] Kinetic examination of enzyme mechanisms involving branched reaction pathways—A detailed consideration of multifunctional glucose-6-phosphatase Original Research Article
Pages 319-353
Robert C. Nordlie

[19] Initial velocity analysis for terreactant mechanisms Original Research Article
Pages 353-366
Ronald E. Viola, W. Wallace Cleland

[20] An analysis of haldane relationships Original Research Article
Pages 366-369
W. Wallace Cleland

[21] Regression analysis, experimental error, and statistical criteria in the design and analysis of experiments for discrimination between rival kinetic models Original Research Article
Pages 370-390
Bengt Mannervik

[22] The use of pH studies to determine chemical mechanisms of enzyme-catalyzed reactions Original Research Article
Pages 390-405
W. Wallace Cleland

[23] Buffers of constant ionic strength for studying pH-dependent processes Original Research Article
Pages 405-426
Keith J. Ellis, John F. Morrison

[24] Two-protonic-state electrophiles as probes of enzyme mechanism Original Research Article
Pages 427-469
Keith Brocklehurst

[25] Application of affinity labeling for studying structure and function of enzymes Original Research Article
Pages 469-499
Bryce V. Plapp

[26] The Yonetani-Theorell graphical method for examining overlapping subsites of enzyme active centers Original Research Article
Pages 500-509
Takashi Yonetani

[27] Determination of binding stoichiometry by the continuous variation method: The job plot Original Research Article
Pages 509-525
Charles Y. Huang

[28] The mechanism of action of yeast inorganic pyrophosphatase Original Research Article
Pages 526-548
Barry S. Cooperman

[29] Solvent isotope effects on enzyme systems Original Research Article
Pages 551-606
K. Barbara Schowen, Richard L. Schowen

[30] Deuterium and tritium kinetic isotope effects on initial rates Original Research Article
Pages 607-625
Dexter B. Northrop

[31] The use of isotope effects to determine transition-state structure for enzymic reactions Original Research Article
Pages 625-641
W. Wallace Cleland

[32] Determination of equilibrium isotope effects by the equilibrium perturbation method Original Research Article
Pages 641-646
W. Wallace Cleland

[33] Isotope exchange studies of regulatory enzymes: “Fingerprint” kinetic patterns for modifier action Original Research Article
Pages 647-711
Frederick C. Wedler, William H. Shalongo

[34] Deduction of kinetic mechanisms from primary Hydrogen isotope effects: Dopamine β-monooxygenase —A case history Original Research Article
Pages 711-732
Susan M. Miller, Judith P. Klinman

[35] Carbonic anhydrase: Oxygen-18 exchange catalyzed by an enzyme with rate-contributing Proton-transfer steps Original Research Article
Pages 732-752
David N. Silverman

Author index
Pages 753-776

Subject index
Pages 777-830