Enteroviruses : omics, molecular biology, and control

Contents
Current Books of Interest
Preface
1 Enteroviruses Future
	Introduction
	Curiouser and curiouser
	Viral eradication and control by vaccination
	Antivirals: crucial for post eradication of poliovirus and needed for all Enteroviruses
	Enteroviruses in 10 years
2 Enterovirus Receptors and Entry
	Introduction
	The Enterovirus capsid
	Attachment to a cellular receptor
	Use of multiple receptors
	Uncoating: formation of expanded A-particles
	Uncoating: RNA release
	Where does uncoating occur?
	Introduction to endocytosis
	Other forms of endocytosis
	Post-internalization events
	Concluding thoughts
3 Hijacking Host Functions for Translation and RNA Replication by Enteroviruses
	Introduction
	Viral proteinase disruption of host machinery
	Use and abuse of host cell functions for viral translation and RNA replication
	Evasion of host antiviral and stress response pathways and mRNA surveillance
	Summary
4 The Omics of Rhinoviruses
	The Rhinoviruses
	How RV taxa are defined
	Making an informative alignment
	Prediction of an RV-C capsid
	Statistical prediction of immunogenicity
	Other uses for RV sequences
5 Viral Population Dynamics and Sequence Space
	Quasispecies dynamics of Enteroviruses: model RNA viruses
	Mutation rates and RdRp fidelity
	Recombination
	Sequence space and fitness landscapes
	Viral adaptation dynamics: step-wise walks along the landscape
	Intra-population interactions: complementation and interference
	Group contribution of minority variants to phenotype
	The genomics era: challenges and prospects of high-throughput sequencing technologies
	Final conclusions
6 Enterovirus Control of Cytoplasmic RNA Granules
	Cytoplasmic RNA granules
	Mechanisms of stress granule assembly
	Enterovirus relationships with stress granules: antagonism rules
	How does G3BP cleavage block stress granule assembly?
	Enterovirus relationships with P-bodies: rapid destruction
	Why Enteroviruses must antagonize RNA granules
	Future directions
7 The Autophagic Pathway and Enterovirus Infection
	Autophagy was first identified in Enterovirus infections through electron microscopy
	Basics of autophagy
	The relationship between Enteroviruses and autophagy
	Release of Enteroviruses without lysis
	Enterovirus proteins promote autophagic signalling and degradation
	Triggering of autophagy upon virus entry
	Coxsackievirus regulation of the autophagy pathway
	Enterovirus 71
	Rhinovirus
	The dual nature of autophagy
	The current model
8 The Lipid Blueprints of Replicating Viral Genomes
	Introduction
	Membranes facilitate replication
	Convergence on a common lipid blueprint
	Advantages of enriching for PI4P lipids in replication organelles
	Mechanisms and consequences of viral induction of PI4P lipid production
	Phosphatidylethanolamine
	Cholesterol: co-factor to stabilize PI4P and phosphatidylethanolamine domains
	Viral mechanisms of obtaining cholesterol
	Therapeutic potential of targeting lipids and future directions
Index