Endorphins in Mental Health Research

Front Matter....Pages i-xx
Front Matter....Pages 1-1
Distribution and pharmacology of the enkephalins....Pages 3-16
β-Endorphin: cellular localization, electrophysiological and behavioral effects....Pages 17-29
Immunohistochemical and biochemical studies of the enkephalins, β-endorphin, and related peptides....Pages 30-44
Effects of opiates and opioid peptides on motor behaviors: sites and mechanisms of action....Pages 45-61
Mapping of leu-enkephalin-containing axons and cell bodies of the rat forebrain....Pages 62-73
Histochemical localization of the enkephalins....Pages 74-83
Isolation and characterization of endogenous [α]-n-acyl derivatives of the C and C′ of lph....Pages 84-92
Behavioral manipulation of rats causes alterations in opiate receptor occupancy....Pages 93-104
Participation of [Met5]-enkephalin in the action of antipsychotic drugs....Pages 105-114
Brain endorphin levels increase after long-term chlorpromazine treatment....Pages 115-118
A re-evaluation of the opioid peptides present in the central nervous system utilizing microfluorometry....Pages 119-130
Front Matter....Pages 131-131
Metabolic regulation of β-endorphin levels in perspective....Pages 131-142
Coordinate synthesis and release of corticotropin and endorphin....Pages 143-157
Biosynthesis and processing of a common precursor to adrenocorticotropin and β-LPH in mouse pituitary cells....Pages 159-180
Enkephalin levels in mouse brain: diurnal variation, post-mortem degradation, and effect of cycloheximide....Pages 181-188
Proteolytic processing in the biosynthesis and metabolism of endorphins....Pages 189-202
Endogenous opioids: cold-induced release from pituitary tissue in vitro; extraction from pituitary and milk....Pages 203-208
Exorphins: peptides with opioid activity isolated from wheat gluten, and their possible role in the etiology of schizophrenia....Pages 209-218
Release and inactivation of opioids in the guinea pig ileum....Pages 219-234
Dynamics of [Met5] — enkephalin storage in rat striatum....Pages 235-241
Front Matter....Pages 243-243
Structure—activity relationships of ß-endorphin by synthesis —1977....Pages 243-253
ß-endorphin: stimulation of DNA-dependent RNA formation....Pages 254-259
Studies on endorphin function in animals and man....Pages 260-268
Analgesia, catatonia and changes in core temperature induced by opiates and endorphins: a comparison....Pages 269-278
Behavioral and biochemical effects of FK 33-824, a parenterally and orally active enkephalin analogue....Pages 279-292
Actions of opiate agonists and substance P on dorsal horn neurons of the cat....Pages 293-301
Effects of endorphins on motor behavior, striatal dopaminergic activity and dopaminergic receptors....Pages 302-306
Characteristics of β-endorphin-induced behavioral activation and immobilization....Pages 307-324
Morphine: exogenous endorphin?....Pages 325-334
Effects of endorphins and their analogues on prolactin and growth hormone secretion....Pages 335-343
Effect of enkephalin on sensory neurons in cell culture: inhibition of substance P release and reduction of inward calcium currents....Pages 344-351
Evidence for tonic activity of enkephalins in brain and development of systemically active analogues with clinical potential....Pages 352-365
Differential binding properties of some opiates and opioid peptides....Pages 366-374
Brain endorphins: possible mediators of pleasurable states....Pages 375-389
Front Matter....Pages 391-391
Use of narcotic antagonists to study the role of endorphins in normal and psychiatric patients....Pages 393-406
Behavioral effects of naloxone and LSD....Pages 407-415
Participation of endorphins in the regulation of pituitary function....Pages 416-422
Naloxone administration in chronic hallucinating schizophrenic patients....Pages 423-434
Effects of naloxone in normal, manic, and schizophrenic patients: evidence for alleviation of manic symptoms....Pages 435-447
Behavioral effects of opioid peptides:implications for future clinical research....Pages 448-451
Front Matter....Pages 391-391
Actions of naloxone in different types of psychoses....Pages 452-460
Effects of naloxone on schedule-controlled behavior in monkeys....Pages 461-472
Possible role of β-endorphin in heat adaptation....Pages 473-483
Naloxone-induced mood and physiologic changes in normal volunteers....Pages 484-491
Front Matter....Pages 493-493
FDA requirements for the study of endorphins....Pages 495-499
β-Endorphin therapy in psychiatric patients....Pages 500-517
Preliminary results of treatment with β-endorphin in depression....Pages 518-528
Demonstration of the analgesic activity of human β-endorphin in six patients....Pages 529-534
β-Endorphin: initial clinical studies....Pages 535-544
Front Matter....Pages 545-545
Possible role of endorphins in schizophrenia and other psychiatric disorders....Pages 545-552
Endorphins in human cerebrospinal fluid and their measurement....Pages 553-560
Plasma β-lipotropin in the human....Pages 561-568
Presence of a non-peptide morphine-like compound in human CSF and urine....Pages 569-575
Pronase P resistant endogenous opiate-like acting materials....Pages 576-580
Characterization of a peptide from the serum of psychotic patients....Pages 581-593
Summary of basic research....Pages 594-600
Summary of clinical research....Pages 601-602
Back Matter....Pages 603-618