مشخصات کتاب

Endogenous Toxins: Targets for Disease Treatment and Prevention

ویرایش:  
 
سری:  
ISBN (شابک) : 9783527323630, 9783527628100 
ناشر:  
سال نشر: 2009 
تعداد صفحات: 967 
زبان: English 
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) 
حجم فایل: 9 مگابایت 

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توضیحاتی درمورد کتاب به خارجی

Designed as a first-stop reference for researchers and professionals in toxicology, pharmacology and medicine, this handbook is the very first to tie together the knowledge from many disciplines that has so far been available only from widely dispersed sources in the primary literature. As such, it presents the complete picture on what is currently known about endogenous toxins, including their generation, mode of action, resulting disease condition, and available countermeasures.
Clearly divided into four parts, the first systematically covers important toxic molecule species, including metabolic intermediates and reactive oxygen species. The second discusses the role of genetically determined metabolic malfunctions, such as galactosemia, hyperlipidemia, porphyria, hemochromatosis and related conditions, while part three looks at acquired and chronic diseases caused or exacerbated by endogenous toxins, such as hepatic injury, asthma, rheumatism, colorectal cancer, reperfusion diseases, neurodegneration and aging. The final part reviews currents strategies to control and minimize the effect of endogenous toxins, either by nutritional or pharmacological interventions.
With its complete coverage integrating molecular and systemic aspects from the biochemical basis to human disease conditions, this comprehensive reference will appeal to a broad target group of toxicologists, biochemists, nutrition specialists and physicians.Content:
Chapter 1 Endogenous DNA Damage (pages 1–42): Erin G. Prestwich and Peter C. Dedon
Chapter 2 Modification of Cysteine Residues in Protein by Endogenous Oxidants and Electrophiles (pages 43–63): Norma Frizzell and John W. Baynes
Chapter 3 Endogenous Macromolecule Radicals (pages 65–101): Arno G. Siraki and Marilyn Ehrenshaft
Chapter 4 Alcohol?Derived Bioadducts (pages 103–132): Geoffrey M. Thiele and Lynell W. Klassen
Chapter 5 Iron from Meat Produces Endogenous Procarcinogenic Peroxides (pages 133–149): Denis E. Corpet, Francoise Gueeraud and Prof. Peter J. O'brien
Chapter 6 Short Chain Sugars as Endogenous Toxins (pages 151–171): Ludmil T. Benov
Chapter 7 Fructose?Derived Endogenous Toxins (pages 173–212): Prof. Peter J. O'Brien, Cynthia Y. Feng, Owen Lee, Q. Dong, Rhea Mehta, Jeff Bruce and Prof. W. Robert Bruce
Chapter 8 Glyceraldehyde?Related Reaction Products (pages 213–225): Teruyuki Usui, Hirohito Watanabe and Fumitaka Hayase
Chapter 9 Estrogens as Endogenous Toxins (pages 227–248): Jason Matthews
Chapter 10 Reactive Oxygen Species, Hypohalites, and Reactive Nitrogen Species in Liver Pathophysiology (pages 249–266): Hartmut Jaeschke
Chapter 11 Oxalate and Primary Hyperoxaluria (pages 267–290): Christopher J. Danpure
Chapter 12 Pathophysiology of Endogenous Toxins and Their Relation to Inborn Errors of Metabolism and Drug?Mediated Toxicities (pages 291–316): Vangala Subrahmanyam
Chapter 13 Mechanisms of Toxicity in Fatty Acid Oxidation Disorders (pages 317–348): J. Daniel Sharer
Chapter 14 Homocysteine as an Endogenous Toxin in Cardiovascular Disease (pages 349–378): Sana Basseri, Jennifer Caldwell, Shantanu Sengupta, Arun Kumar and Richard C. Austin
Chapter 15 Uric Acid Alterations in Cardiometabolic Disorders and Gout (pages 379–394): Renato Ippolito, Ferruccio Galletti and Pasquale Strazzullo
Chapter 16 Genetic Defects in Iron and Copper Trafficking (pages 395–418): Douglas M. Templeton
Chapter 17 Polyglutamine Neuropathies: Animal Models to Molecular Mechanisms (pages 419–447): Kelvin Hui and Jeffrey Henderson
Chapter 18 Alcohol?Induced Hepatic Injury (pages 449–483): Emanuele Albano
Chapter 19 Ethanol?Induced Endotoxemia and Tissue Injury (pages 485–509): Radhakrishna K. Rao
Chapter 20 Gut Microbiota, Diet, Endotoxemia, and Diseases (pages 511–524): Patrice D. Cani and Nathalie M. Delzenne
Chapter 21 Nutrient?Derived Endogenous Toxins in the Pathogenesis of Type 2 Diabetes at the ??Cell Level (pages 525–555): Christine Tang, Andrei I. Oprescu and Adria Giacca
Chapter 22 Endogenous Toxins and Susceptibility or Resistance to Diabetic Complications (pages 557–576): Paul J. Beisswenger
Chapter 23 Serum Advanced Glycation End Products Associated with NASH and Other Liver Diseases (pages 577–593): Hideyuki Hyogo, Sho?ichi Yamagishi and Susumu Tazuma
Chapter 24 Oxidative Stress in the Pathogenesis of Hepatitis C (pages 595–617): Tom S. Chan and Marc Bilodeau
Chapter 25 Oxidized Low Density Lipoprotein Cytotoxicity and Vascular Disease (pages 619–645): Steven P. Gieseg, Elizabeth Crone and Zunika Amit
Chapter 26 Oxidative Stress in Breast Cancer Carcinogenesis (pages 647–672): Lisa J. Martin and Norman Boyd
Chapter 27 Lifestyle, Endogenous Toxins, and Colorectal Cancer Risk (pages 673–693): Gail McKeown?Eyssen, Jeff Bruce, Owen Lee, Prof. Peter J. O'Brien and Prof. W. Robert Bruce
Chapter 28 Dopamine?Derived Neurotoxicity and Parkinson's Disease (pages 695–714): Jose Luis Labandeira?Garcia
Chapter 29 Dopamine Catabolism and Parkinson's Disease: Role of a Reactive Aldehyde Intermediate (pages 715–731): Jonathan A. Doorn
Chapter 30 Tetrahydropapaveroline, an Endogenous Dicatechol Isoquinoline Neurotoxin (pages 733–746): Young?Joon Surh and Hyun?Jung Kim
Chapter 31 Chemically Induced Autoimmunity (pages 747–768): Michael Schiraldi and Marc Monestier
Chapter 32 Endogenous Toxins Associated with Life Expectancy and Aging (pages 769–786): Victoria Ayala, Jordi Boada, Jose Serrano, Manuel Portero?Otin and Reinald Pamplona
Chapter 33 Therapeutic Potential for Decreasing the Endogenous Toxin Homocysteine: Clinical Trials (pages 787–839): Wolfgang Herrmann and Rima Obeid
Chapter 34 Prevention of Oxidative Stress–Induced Diseases by Natural Dietary Compounds: The Mechanism of Actions (pages 841–857): Tin Oo Khor, Ka?Lung Cheung, Avantika Barve, Harold L. Newmark and Ah?Ng Tony Kong
Chapter 35 Genotoxicity of Endogenous Estrogens (pages 859–879): James S. Wright
Chapter 36 Design of Nutritional Interventions for the Control of Cellular Oxidation (pages 881–906): Elizabeth P. Ryan and Henry J. Thompson

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