Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

Front Matter ....Pages i-viii
Front Matter ....Pages 1-1
 Regulatory T Cells: Molecular and Cellular Basis for Immunoregulation  (Yosuke Togashi, Hiroyoshi Nishikawa)....Pages 3-27
 Overview of LAG-3-Expressing, IL-10-Producing Regulatory T Cells  (Keishi Fujio, Kazuhiko Yamamoto, Tomohisa Okamura)....Pages 29-45
 Regulatory Dendritic Cells  (Katsuaki Sato, Tomofumi Uto, Tomohiro Fukaya, Hideaki Takagi)....Pages 47-71
Front Matter ....Pages 73-73
 Role of PD-1 in Immunity and Diseases  (Kenji Chamoto, Muna Al-Habsi, Tasuku Honjo)....Pages 75-97
 CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation  (Shunsuke Chikuma)....Pages 99-126
 Tim-3, Lag-3, and TIGIT  (Nicole Joller, Vijay K. Kuchroo)....Pages 127-156
Front Matter ....Pages 157-157
 SOCS1: Regulator of T Cells in Autoimmunity and Cancer  (Subburaj Ilangumaran, Diwakar Bobbala, Sheela Ramanathan)....Pages 159-189
 Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity  (Claudia Penafuerte, Luis Alberto Perez-Quintero, Valerie Vinette, Teri Hatzihristidis, Michel L. Tremblay)....Pages 191-214
 Immune Regulation by Ubiquitin Tagging as Checkpoint Code  (Peng Zeng, Jieyu Ma, Runqing Yang, Yun-Cai Liu)....Pages 215-248
 MicroRNA in Immune Regulation  (Cheng-Jang Wu, Li-Fan Lu)....Pages 249-267