Electrical Diseases of the Heart: Volume 1: Basic Foundations and Primary Electrical Diseases

Front Matter....Pages i-xxi
Front Matter....Pages 1-1
Introduction to Part I: Basic Cardiac Electrophysiology – Promises Kept and Promises to Keep....Pages 3-5
Basic Physiology of Ion Channel Function....Pages 7-24
Developmental Aspects of the Electrophysiology of the Heart: Function Follows Form....Pages 25-45
Anatomic and Histopathologic Characteristics of the Conductive Tissues of the Heart....Pages 47-71
Neural Regulation of the Heart in Health and Disease....Pages 73-92
Mechanisms of Cardiac Arrhythmia....Pages 93-128
Mechanisms of Action of Antiarrhythmic Drugs in Ventricular Arrhythmias....Pages 129-140
Mechanisms of Action of Antiarrhythmic Drugs in Atrial Fibrillation....Pages 141-156
Mechano-Electric Interactions and Their Role in Electrical Function of the Heart....Pages 157-175
Pathological Roles of the Cardiac Sodium Channel Late Current (Late I Na )....Pages 177-191
Sodium Ion Channelopathies....Pages 193-207
L-Type Calcium Channel Disease....Pages 209-217
Nerve Sprouting, Defibrillation and Calcium Waves....Pages 219-232
K + Channelopathies (I Ks , I Kr , and I to )....Pages 233-244
Cardiac ATP-Sensitive Potassium Channels and Associated Channelopathies....Pages 245-258
Cardiac K ATP Channels in Health and Diseases....Pages 259-279
Ca 2+ Release Channels (Ryanodine Receptors) and Arrhythmogenesis....Pages 281-297
Caveolae and Arrhythmogenesis....Pages 299-315
Senescence and Arrhythmogenesis....Pages 317-332
Comparisons of Substrates Responsible for Atrial Versus Ventricular Fibrillation....Pages 333-352
Front Matter....Pages 1-1
Single Nucleotide Polymorphisms in Health and Cardiac Disease....Pages 353-367
Electrophysiological Remodeling in Heart Failure....Pages 369-386
Ventricular Electrical Remodeling in Compensated Cardiac Hypertrophy....Pages 387-398
Physiological and Other Biological Pacemakers....Pages 399-414
Cardiac Memory: From Electrical Curiosity to Clinical Diagnostic and Research Tool....Pages 415-433
Front Matter....Pages 435-435
Introduction to Part Two: Celebrating the Challenge of Cardiac Arrhythmias....Pages 437-437
Congenital Long QT Syndrome....Pages 439-468
Brugada Syndrome: Clinical and Genetic Aspects....Pages 469-495
Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy....Pages 497-536
Early Repolarization Syndrome: Epidemiology, Genetics, and Risk Stratification....Pages 537-550
Catecholaminergic Polymorphic Ventricular Tachycardia....Pages 551-560
Andersen-Tawil and Timothy Syndromes....Pages 561-567
Short QT Syndrome....Pages 569-581
Progressive Cardiac Conduction Disease....Pages 583-603
Genetics of Atrial Fibrillation and Standstill....Pages 605-627
Idiopathic Ventricular Fibrillation....Pages 629-646
Back Matter....Pages 647-659