Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury: Proceedings of the 2nd International Conference September 17–21, 1991 Berlin, FRG

Front Matter....Pages i-xlviii
Front Matter....Pages 1-1
Mutagenesis of Six Conserved Histidines in Human 5-Lipoxygenase, Effects on Enzyme Activity....Pages 3-6
Arachidonate 12-Lipoxygenases: Enzymology and Molecular Biology....Pages 7-10
Cytochrome P-450 Epoxygenase Dependent Formation of Novel Endogenous Epoxyeicosatrienoyl-Phospholipids....Pages 11-15
The Significance of the Peroxide Tone in the Arachidonic Acid Cascade....Pages 17-21
Properties and Functions of an Epidermal 8-Lipoxygenase....Pages 23-26
On the Biological Role of Mammalian 15-Lipoxygenases....Pages 27-30
Studies on Expression and Regulation of 5-Lipoxygenase in Human B Lymphocytes....Pages 31-34
Platelet-Activating Factor Induces Receptor Mediated Leukocyte 5 Lipoxygenase Activation Through its Translocation to the Membrane....Pages 35-38
Leukotriene A 4 Hydrolase: A Zinc Metalloenzyme with Dual Enzymatic Activities....Pages 39-42
Mutations of the Three Zinc-Ligands of Leukotriene A 4 Hydrolase: Effects on Zinc Content and Enzyme Activities....Pages 43-46
Effects of Anions on the Peptidase Activity of Leukotriene A 4 Hydrolase....Pages 47-50
ESR Investigation of Tyrosyl Radicals of Prostaglandin H Synthase; Relation to Enzyme Catalysis....Pages 51-53
Histidine Residues Involved in Heme Binding by Prostaglandin Endoperoxide Synthase....Pages 55-57
Chemical Modifications of Prostaglandin Endoperoxide Synthase with N-Acetylimidazole and Tetranitromethane....Pages 59-62
Rous Sarcoma Virus Induces a New Form of Prostaglandin G/H Synthase (Cyclooxygenase)....Pages 63-66
3-Hydroxy-5,8,11,14 (All CIS )-Eicosatetraenoic Acid (3-Hete) — A New Aspirin Sensitive Arachidonic Acid Metabolite from Yeast....Pages 67-70
Gestational Age Related Changes in Platelet Activating Factor Acetylhydrolase Activity in Maternal Plasma....Pages 71-74
Phospholipid Hydroperoxide Glutathione Peroxidase: A Selenoprotein Distinct from Glutathione Peroxidase....Pages 75-78
Front Matter....Pages 79-79
Disturbances of Lipid Peroxidation in Rat Liver Cancer Cells and in Normal Regenerating Rat Liver....Pages 81-83
Identification of Novel Prostaglandin-Containing Glycerophospholipids in vivo ....Pages 85-88
Front Matter....Pages 79-79
Susceptibility to Lipid Peroxidation of Rat Hepatoma Cells Enriched with Arachidonic Acid....Pages 89-97
Human Reperfusion Injury: The Role of Free Radicals....Pages 99-102
Hydrogen Peroxide as Inflammatory Mediator....Pages 103-105
Relationships Between Ascorbic Acid and Glutathione in Antioxidant Defense....Pages 107-109
Antioxidant and Hepatoprotective Properties of IdB 1016, A New Flavanolignan Complex....Pages 111-113
Absorption and Transport of Vitamin E....Pages 115-118
Protection Against Lipid Peroxidation by Vitamin E-Acetate is Higher in Liver than in Kidney....Pages 119-123
Enhancement of Hydroxyl Radical Induced Methionine Oxidation to Methionine Sulfoxide by the Vitamin E Analogue Trolox C....Pages 125-128
Plasma Membrane Structure, Calcium and Microfilaments in Anoxia....Pages 129-131
Front Matter....Pages 133-133
Prostanoids, Prostanoid Receptors and Tumor Progression....Pages 135-141
Pharmacological Characterization of the Prostanoid FP-Receptor....Pages 143-146
PGE 2 Receptors: Involvement of EP2 and EP3 Subtypes in the Chick Spinal Cord....Pages 147-150
Thromboxane A 2 Receptors: Characterization and Regulation....Pages 151-154
The Second Leukotriene Receptor in Human Lung....Pages 155-158
Front Matter....Pages 159-159
Molecular Diversity and Functional Considerations in Transmembrane Signalling by G Proteins....Pages 161-174
Function of Sphingolipid Metabolites in Cell Regulation....Pages 175-181
Cell Signaling in LPS Primed and PAF Stimulated P388D 1 Macrophage-Like Cells....Pages 183-186
Cellular Phospholipases A 2 in Inflammatory Processes....Pages 187-190
Regulation of Eicosanoid Formation in Liver Macrophages: Role of Phospholipase A 2 ....Pages 191-193
Enhancement by Staurosporine of PLA 2 -Activity and PAF-Biosynthesis in FMLP- Stimulated Human Neutrophils: Specific Role of Endogenously Synthesized PAF....Pages 195-199
Front Matter....Pages 159-159
Phosphorylation/Dephosphorylation Possibly Regulate Cellular PLA 2 and Pl- PLC- γ 1 Activity: Implication for the Mechanism of H 2 O 2 and Glucocorticoid Action....Pages 201-208
 Hydra Tentacle Regeneration: A Model for the Study of the Involvement of Protein Kinase C and Phospholipase A 2 in Cell Differentiation....Pages 209-212
Concerted Mitogenic Signals Control Mammalian DNA Replication Protein Kinase C Role....Pages 213-218
12(S)-Hete-Induced Microvascular Endothelial Cell Retraction is Mediated by Cytoskeletal Rearrangement Dependent on PKC Activation....Pages 219-229
Inhibition of Human Platelet Aggregation by Novel 2-Aminochromone Phospholipase C Inhibitors....Pages 231-233
Arachidonic Acid is Involved in Catecholamine Release Mechanism of PGE 2 in Bovine Adrenal Chromaffin Cells....Pages 235-238
Effect Of A23187 Stimulation on Subcellular Redistribution of 15-Lipoxygenase Activity in Human Leukocytes....Pages 239-242
Enhancement of Phospholipase C and Phospholipase D Activity by Staurosporine in N-Formyl-Methionin-Leucin-Phenylalanine- Stimulated Human Neutrophils....Pages 243-247
Hepoxilins Activate Phospholipase D in the Human Neutrophil....Pages 249-252
Front Matter....Pages 253-253
Regulation of Eosinophil Programmed Cell Death and the Subsequent Priming of Ligand Mediated Functions by the Eosinophil-Directed Hematopoietins....Pages 255-259
In Vivo Desensitization to LTB4-Induced Neutrophil Sequestration in Rabbit Lungs....Pages 261-263
Synthesis of 20-Hydroxy Arachidonic Acid by the Human Neutrophil and Platelet Metabolism....Pages 265-270
Leukotoxin, a Linoleate Epoxide, and Severe Inflammation....Pages 271-274
Epidermal Cell-Polymorphonuclear Leukocyte Cooperation in the Formation of Leukotriene B 4 by Transcellular Biosynthesis....Pages 275-278
Contribution of Bidirectional Transcellular Routes to Lipoxin Biosynthesis....Pages 279-282
The Effect of Lipoxin on the Binding of [ 3 H]LTB 4 to Guinea PIG Eosinophils....Pages 283-290
Stimulus Dependent Formation of Leukotriene B 4 in Human Alveolar Macrophages....Pages 291-294
Transport and Elimination of Cysteinyl Leukotrienes....Pages 295-298
Mast Cells are Essential for the Formation of Leukotrienes Initiating Early Inflammatory Responses....Pages 299-302
Importance of Prostanoids for Bronchial Smooth Muscle Tone....Pages 303-306
Front Matter....Pages 253-253
Neuropeptides and Airway-Inflammation....Pages 307-311
PAF and Related Lipids Regulate Events in the Vascular Wall....Pages 313-316
Use of PCR-Technique for Determination of Cell Adhesion Molecule Transcription in Human Endothelial Cells....Pages 317-320
Front Matter....Pages 321-321
Cytokines Interaction in Innate and Immunomodulator-Induced Radioprotection....Pages 323-328
Variations in the Profiles of Radioprotective Eicosanoids....Pages 329-331
Radiation Injury and Antioxidant Mechanisms of Protection....Pages 333-339
Reduction of Short- and Long-Term Lethality by Prostaglandins Given Alone or in Association with Other Protectors....Pages 341-343
The Effects of SO-1100 in Reducing the Severity of Radiation-Induced Damage to Pig Skin....Pages 345-348
Protection of Thymocytes from Radiation-Induced Interphase Death by Dihydrolipoic Acid and WR-1065....Pages 349-352
Protective Roles of MnSOD, TNF-α, TNF-β and D-Factor in Radiation Injury....Pages 353-357
Radioprotective Efficacy of Platelet Activating Factor in Mice....Pages 359-367
Low Level Radiation Effects on Endothelial Cell Eicosanoid Biosynthesis....Pages 369-375
Capsaicin and Its Protective Effect Against UV-Induced Lipid Peroxidation on Liposomal Preparations....Pages 377-380
Front Matter....Pages 381-381
Chronic Inflammation is a Major Cause of Preventable Cancer....Pages 383-385
Inflammation and Oxidative Stress in Carcinogenesis....Pages 387-390
Intracellular Signal Transduction and Skin Tumor Promotion (A Minireview)....Pages 391-394
Oxidant Generation in Mouse Skin in Response to Phorbol Ester Tumor Promoters....Pages 395-399
Antioxidant-Prooxidant Status of Murine Skin During the Ontogeny of Chemically-Induced Skin Cancer....Pages 401-404
Profiling of Monohydroxylated Fatty Acids in Normal, Hyperplastic and Neoplastic Mouse Epidermis by Gas Chromatography-Mass Spectrometry....Pages 405-408
Free Radical Metabolism and DNA Damage by Organic Peroxide Tumor Promoters....Pages 409-413
Front Matter....Pages 381-381
Does Superoxide Anion Have a Role in Phorbol Ester Tumor Promotion ?....Pages 415-418
Ovine Seminal Vesicle Cell Cultures, A Tool for Studies of Carcinogen Activation by Prostaglandin H Synthase....Pages 419-421
Defective Heme Biosynthesis as the Initiating Lesion in Carcinogenesis....Pages 423-425
Inhibitors of Prostaglandin Synthesis in Cancer Chemoprevention....Pages 427-429
Sphingolipids Inhibit Protein Kinase C and Multistep Transformation....Pages 431-434
Linoleic Acid Specifically Stimulates the Growth of Hepatoma Cell Lines Transfected with the Target Protein of a Liver Carcinogen....Pages 435-438
Chemopreventive Modulation of Human Mammary Carcinogenesis by Bioactive Lipids....Pages 439-446
Formation of 8-Hydroxyguanine in DNA by Oxygen Radicals and Its Repair Enzyme....Pages 447-451
Detection of DNA Adducts of Unsaturated Fatty Acid Hydroperoxides by 32 P-Postlabeling Analysis....Pages 453-455
Front Matter....Pages 457-457
Transforming Growth Factor Alpha Stimulated Phospholipase A 2 Activity in Mouse Keratinocytes....Pages 459-462
Epidermal Growth Factor Enhances a Microsomal 12 — Lipoxygenase Activity in A431 Cells....Pages 463-466
Epidermal Growth Factor Regulation of Linoleic Acid Metabolism in Syrian Hamster Embryo Fibroblasts....Pages 467-470
Insulin-Like (IGF-I, IGF-II), Epidermal (EGF) and Alpha Transforming (TGF-α) Growth Factors in Human Breast Cyst Fluid (BCF)....Pages 471-474
Restriction Polymorphisms in Tyrosine Kinase Genes in Cells Transformed by Reactive Oxidants: Evidence for Concerted Methylation Changes in a Family of Genes....Pages 475-478
Effects of Hyperthermia on Patterns of Eicosanoid Synthesis; Potential Roles in Altered Cell Behaviour and Gene Expression....Pages 479-483
Front Matter....Pages 485-485
Interregulatory Effects of Eicosanoids and Cytokines....Pages 487-489
Cytokine-Induced Phospholipase A 2 and Its Possible Relationship to Eicosanoid Formation....Pages 491-495
Eicosanoid and Cytokine Production by the Pulmonary Alveolar Macrophage....Pages 497-502
Regulation of Nitric Oxide Synthesis in Liver Macrophages by Lipopolysaccharide, Cytokines and Prostaglandin E 2 ....Pages 503-506
Interleukin-1 Stimulates Arachidonic Acid 15-Hydroxylation in Human Endothelial Cells....Pages 507-511
Front Matter....Pages 485-485
IL-1 Stimulates the Linoleic Acid Metabolism in Human Dermal Fibroblasts....Pages 513-516
Inhibition of Prostaglandin E2 (PGE2) by Human Recombinant Interleukin-1 Receptor Antagonist (hrIL-1ra)....Pages 517-523
Activation by Interleukin-1 of Human Synovial Cell, Human Skin and Lung Fibroblast Proliferation. Interaction with the Arachidonic Acid-Derived Metabolites....Pages 525-529
Front Matter....Pages 531-531
The Role of Eicosanoids and Linoleic Acid Metabolites in Epidermal Growth Factor Dependent Cellular Proliferation....Pages 533-536
Role of Phospholipid Metabolites in the Cell Cycle Delay Caused by Epidermal Growth Factor at the Transition from G2-Phase to Mitosis in A431 Cells....Pages 537-540
Effect of a Novel 5-Lipoxygenase Inhibitor, E6080 on the Eicosanoid Production of Human Peritoneal Cells....Pages 541-546
Role of an 8-Lipoxygenase in the Maturation of Starfish Oocytes....Pages 547-550
Fatty Acids in Malignancy....Pages 551-554
Selective Cytotoxicity of Certain Essential Fatty Acids Towards Tumour Cells....Pages 555-558
Anti-Tumor Prostaglandins Facilitate Mineralization by Human Osteoblasts....Pages 559-562
Effects of Castration and Estrogen Treatment on Tissue Levels of Prostaglandins in the Dunning R3327 Rat Prostatic Adenocarcinoma....Pages 563-567
Immunohistochemical Localization of Thromboxane Synthase in Normal and Neoplastic Tissues by the Monoclonal Antibody Tü 300....Pages 569-571
Effect of Stearic Acid on Human Cervical Cancer Cell Growth....Pages 573-575
Measurements on Individual Cells from Human Cervical Squamous Epithelium: Distinctions between Normal Cases and Cases of Cervical Intraepthelial Neoplasia....Pages 577-584
Modulatory Effects of PGD 2 -Analogue ZK 110 841 on Tumor Cell Proliferation....Pages 585-589
The Effects of Leukotrienes on Glioma Cell Proliferation in Vitro....Pages 591-595
Inhibition of Glioma Growth by Lipoxygenase Inhibitors and PAF-Antagonists....Pages 597-601
The New Anticancer Drug Ilmofosine Enhances the Activity of CIS-Platin and Reverses Multidrug Resistance....Pages 603-605
Lipid Activators of Protein Kinase C and Their Role in the Multidrug Resistance Phenotype of Tumor Cells....Pages 607-609
Front Matter....Pages 611-611
Eicosanoid Regulation of Tumor Cell-Platelet and -Endothelium Interaction During Arrest and Extravasation....Pages 613-617
Front Matter....Pages 611-611
Fatty Acid Regulation of Endothelial Cell Adhesion Molecules and Tumor Cell Adhesion: Implications in Metastasis....Pages 619-621
Effect of EFA Deficiency on the Metastatic Potential of RSV-Transformed Fibroblastic Lines....Pages 623-627
Activation Of Protein Kinase C by 12(S)-HETE: Role in Tumor Cell Metastasis....Pages 629-634
12-(S)-HETE Induces Cytoskeleton Phosphorylations and Rearrangement in Melanoma Cells....Pages 635-638
Fatty Acid Modulation of Cancer Cell Spreading and Cytoskeleton Rearrangement....Pages 639-643
Effect of 12-HETE on the Expression of Autocrine Motility Factor-Receptor and Motility in Melanoma Cells....Pages 645-649
Mechanisms of the Antimetastatic Activity of Prostanoids....Pages 651-655
Demonstration of Antimetastatic Effects of Prostacyclin Analogues In Vivo....Pages 657-662
The Stable Prostacyclin Analogue Cicaprost Inhibits Tumor Metastases in M5076 Reticulum Sarcoma....Pages 663-666
Transformation of Exogenous Arachidonic Acid into a New Metabolite, 12-Keto- 5,8,10,14-Eicosatetraenoic Acid by Lewis Lung Carcinoma Cells: Implications in Tumor Cell Metastasis....Pages 667-670
Enhanced Membrane Expression Of Cytoadhesion α IIb β 3 in Lewis Lung Carcinoma Cells by Epoxyeicosatrienoic Acids....Pages 671-678
Cysteinyl-Leukotriene Production by Human Astrocytomas In Vivo Correlates with the Malignancy Grade and the Perifocal Edema....Pages 679-681
Radiation Enhances Tumor Cell Metastasis....Pages 683-687
Front Matter....Pages 689-689
The Role of a COA-Independent Transacylase in the Movement of Arachidonate among Phospholipids and the Synthesis of PAF....Pages 691-697
Antitumour Ether Lipids and Platelet-Activating Factor Analogues Have Different Cytotoxic Profiles and Calcium Mobilizing Effects — a Structure-Activity Study....Pages 699-702
Ether Lipid Antitumor Agents Inhibit Phosphatidylinositol Phospholipase C....Pages 703-706
Biological Activity of a New Ketone-Containing Analog of Edelfosine....Pages 707-711
Scanning Electron Microscope Study of the Effect of Alkyl-Lysophospholipid on Bone Marrow and Leukemic Cells....Pages 713-719
Interference of ALP on Tumor Cell Adhesion to Activated Human Endothelial Cells....Pages 721-725
Platelet-Activating Factor: Its Regulation in Parturition....Pages 727-730
Front Matter....Pages 689-689
Some Novel Observations on Inhibitors of Platelet Activating Factor Induced Reactions....Pages 731-733
Front Matter....Pages 735-735
Prostaglandin J 2 and Related Compounds: Preclinical Results and Gene Mechanisms....Pages 737-739
Alkyl Lysophospholipids in Cancer Treatment: Their Cytostatic and Immunomodulatory Role....Pages 741-748
Changes in the Tissue Fatty Acid Composition in Murine Malignancy and Following Anticancer Therapy....Pages 749-751
Disorders of Vascular Permeability: Pathophysiological and Clinical Implications....Pages 753-757
Analysis of 5-Lipoxygenase and 5-Lipoxygenase-Activating Protein in Neutrophil Granulocytes from Patients with Sepsis and Sepsis Syndrome....Pages 759-761
Leukotrienes as Mediators of Airway Obstruction in Asthmatics: Experimental Findings and Clinical Studies....Pages 763-766
Potentiation of Tumor Radioresponse by Combination of Indomethacin with the Hypoxic Cell Radiosensitizer Misonidazole....Pages 767-770
Elevated Rectal Leukotriene B 4 , Thromboxane B 2 and Prostaglandin E 2 Levels in Patients Having Pelvic Radiotherapy....Pages 771-773
Mediators of Endothelial Cell Injury Following Total Body Irradiation in Bone Marrow Transplant Patients: The Role of Thromboxane and Leukotrienes....Pages 775-777
Quantification of PAF in Plasma from Kidney Transplant Patients by Radio Receptor Assay (PAF-RRA)....Pages 779-783
Back Matter....Pages 785-799