Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5

Front Matter....Pages i-xvii
Phospholipase A2 Modification of Lipoproteins: Potential Effects on Atherogenesis....Pages 3-7
Type IIA Secretory PLA 2 -Mediated Delayed PGE 2 Biosynthesis is Regulated by the Products of the Cytosolic PLA 2 ....Pages 9-13
Functional coupling between Phospholipase a2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways....Pages 15-19
Cytosolic Phospholipase A2a Interacts With Microtubules....Pages 21-24
Group IV Cytosolic Phospholipase A 2 (Pla 2 ) Function:Insights from the Knockout Mouse....Pages 25-31
Investigation Into the Involvement of Phospholipases A2 and Map Kinases in Modulation of Aa Release and Cell Growth in A549 Cells....Pages 33-40
Participation of Cytosolic Phospholipase A2 in Eicosanoid Generation by Mouse Bone Marrow-Derived Mast Cells....Pages 41-46
Analysis of Cyclooxygenase-Substrate Interactions Using Stereospecificallylabeled Arachidonic Acids....Pages 49-53
Sequence Determinants For The Positional Specificity Of Lipoxygenases....Pages 55-60
Regulation Of Leukotriene C4 Synthase Gene Expression By Sp1 And Sp3 In Mononuclear Phagocytes....Pages 61-66
Pgg 2 11r-Hpete and 15r/S-Hpete are Formed From Different Conformers of Arachidonic Acid in the Prostaglandin Endoperoxide H Synthase-1 Cyclooxygenase Site....Pages 67-72
Suppression of Cyclooxygenase-2 Gene Transcription by Humulon....Pages 73-77
Inhibition of 5-lo Activating Protein (Flap) Activity Decreases Proteinuria in Streptozotocin(Stz)-induced Diabetic Rats.....Pages 79-83
Inhibition of Ultraviolet Light B-Induced Cutaneous Inflammation by A Specific Cyclooxygenase-2 Inhibitor....Pages 85-92
Cyclooxygenase-2 Expression and Activity are Induced by Amyloid-Beta 1-42 in Brain-Derived Cells....Pages 93-99
Down-regulation of 5-lipoxygenase activity and leukotriene production by prolonged exposure to Lipopolysaccharide....Pages 101-105
Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF 1α , a potent epithelial Secretagogue....Pages 107-112
Substrate Down Regulation of 12-lipoxygenase in Human Platelets....Pages 113-116
Calcium Binding to 5-Lipoxygenase....Pages 117-121
Expression Of Cycloxygenase-2 In Human Bladder And Renal Cell Carcinoma....Pages 123-126
Modulation of Cyclooxygenase-2 Expression by Apc In Ht-29 Human Colorectal Carcinoma Cells....Pages 127-131
15-Lipoxygenase-1 Overexpression in Prostate Adenocarcinoma....Pages 133-145
Characterization of Epidermal 12( S ) and 12( R ) Lipoxygenases....Pages 147-153
Selective Inhibition of Cyclooxygenase-2 Attenuates Expression of Inflammation-Related Genes in Cns Injury....Pages 155-160
Intracellular Activation and Induction of 12-lipoxygenase in Mouse Peritoneal Macrophages....Pages 161-164
Epidermis-Type Lipoxygenases....Pages 165-170
Manganese Lipoxygenase Has A Mononuclear Redox Center....Pages 171-176
Cyclooxygenase-2 In Human Pathological Disease....Pages 177-184
Leukotriene D 4 -Induced Calcium Signaling in Human Intestinal Epithelial Cells....Pages 187-191
Do Leukotrienes Increase Cell Viability in Human Intestinal Epithelial Cells?....Pages 193-198
Aspirin-Triggered 15-Epi-Lipoxin A 4 Biosynthesis in Rat Liver Cells....Pages 199-209
Inhibition of Allergen-Induced Eosinophil Migration by Lipoxin (LX)A 4 and Aspirin-Triggered 15-Epi-LXA 4 ....Pages 211-216
Anti-Leukotrienes as Novel Anti-Inflammatory Treatments in Asthma....Pages 217-221
Lipoxin A 4 and Aspirin-Triggered 15-Epi-Lipoxin A 4 Modulate Adhesion Molecule Expression on Human Leukocytes in Whole Blood and Inhibit Neutrophil-Endothelial Cell Adhesion....Pages 223-228
Mechanisms of Active Intestinal Inflammation and Potential Down-Regulation Via Lipoxins....Pages 229-236
Interactions Between 5-Oxo-Ete and Chemokines in Stimulating Eosinophils....Pages 237-242
Structure and Function of Human Nad + -Linked 15-Hydroxyprostaglandin Dehydrogenase....Pages 245-250
Catalytic Properties of Purified Recombinant Anandamide Amidohydrolase....Pages 251-256
Purification and Characterization of Membrane-Bound Prostaglandin E Synthase from Bovine Hearts....Pages 257-262
cDNA Cloning and Mutagenesis Study of Liver-Type Prostaglandin F Synthase, and Identification of the Prostaglandin F Producing Cells in the Liver....Pages 263-268
Determination of Cyclooxygenase and Arachidonic Acid Metabolites in Invasive Human Prostate Cancer Cells....Pages 269-274
Effects Of Overexpression Of Prostacyclin Synthase In Vascular Smooth Muscle Cells....Pages 275-280
Analysis of the Transcriptional Regulation of Mouse Prostacyclin Synthase Gene....Pages 281-286
Characterization of Microsomal, Glutathione Dependent Prostaglandin E Synthase....Pages 287-291
 Activation-Dependent Internalization of The Human Prostacyclin Receptor ....Pages 295-301
The Design and Synthesis of Selective Prostaglandin Analogs As Bone Anabolic Agents for the Potential Treatment of Osteoporosis....Pages 303-307
Leukotrienes and the Pulmonary Vascular Bed....Pages 309-313
The Contraction of the Human Pulmonary Artery by LTC 4 is Resistant to CYSLT 1 Antagonists and Counteracted by Prostacyclin Release....Pages 315-319
Targeted gene disruption of the prostaglandin e2 ep2 receptor....Pages 321-326
Ocular Hypotensive Activity of Prostaglandin F 2 α (PGF 2 α) Analogs with Neutral Substituents at Position 1 is Predicted by the Isolated Cat Iris Sphincter Smooth Muscle Preparation but not Ca + Signalling in Swiss 3T3 Cells....Pages 327-330
Prostanoid FP Receptor Mediated, Endothelium Dependent Vasodilatation and the Ocular Surface Hyperemic Response to PGF 2 α and Related Compounds....Pages 331-336
Regulation of Cd36 Expression In Human Melanoma Cells....Pages 337-342
Novel Eicosanoid Activators of PPARγ Formed by Raw 264.7 Macrophage Cultures....Pages 343-349
Isoprostane Activation of the Nuclear Hormone Receptor Ppar....Pages 351-355
In Vivo Chemotaxis Using Cho Cells Expressing Human Leukotriene B4 Receptor....Pages 357-361
Mechanism of Inhibition of Novel Cox-2 Inhibitors....Pages 365-369
Chemopreventive Effects of Nimesulide, A Selective Cyclooxygenase-2 Inhibitor, Against Phip-Induced Mammary Carcinogenesis....Pages 371-376
Antitumor Effects of Piroxicam in Spontaneous Canine Invasive Urinary Bladder Cancer, A Relevant Model of Human Invasive Bladder Cancer....Pages 377-380
Cannabimimetic Eicosanoids in Cancer and Inflammation: an Update....Pages 381-386
Acetyl-11-Keto-ß-Boswellic Acid (Akba) is Cytotoxic for Meningioma Cells and Inhibits Phosphorylation of the Extracellular-Signal Regulated Kinase 1 and 2....Pages 387-393
Cyclooxygenase-2 Induction in Rat Spinal Cord Injury Mediated By Proinflammatory Tumor Necrosis Factor-α and Interleukin-1....Pages 397-401
Growth Stimulation and Epidermal Growth Factor Receptor Induction in Cyclooxygenase-Overexpressing Human Colon Carcinoma Cells....Pages 403-407
Relationship Between Apoptosis, Angiogenesis And Colon-26 Tumour Growth After Oral Nsaid-Treatment....Pages 409-414
Molecular Mechanisms of Prostate Cancer Cell Death Triggered by Inhibition of Arachidonate 5-Lipoxygenase: Involvement of Fas Death Receptor-Mediated Signals....Pages 415-420
induction of apoptosis in mouse t cells upon peroxisome proliferator-activated receptor gamma (ppar-γ) binding....Pages 421-425
Nitration of cytochrome c by peroxynitrite: a putative anti-apoptotic pathway mediated by prostaglandin h2 Synthase (pghs) and nitric oxide (no) synthase....Pages 427-431
Apoptosis In Vascular Smooth Muscle Accompanied By Increases In Arachidonic Acid....Pages 433-437
Sphingolipids In Vascular Biology....Pages 439-444
Cyclooxygenase-2: A Molecular Target For Chemoprevention Of Epithelial Tumors Of Skin And Colon....Pages 445-448
Mk 886 Functions As A Radiomimetic Agent: Genomic Responses Related to Oxidative Stress, The Cell Cycle, Proliferation and Programmed Cell Death in Panc-1 Cells....Pages 451-456
Lps-Induced Synthesis and Release of Pge 2 in Liver Macrophages: Regulation by Cpla 2 , Cox-1, Cox-2, and Pge 2 Synthase....Pages 457-462
13(S)-Hpode Modulates Mitogenic Signal Transduction Through Enhancing The Phosphorylation and Association of Egf Receptor with the Tyrosine Phosphatase Shp-2....Pages 463-467
Ku 70/80 Lupus Autoantigen is the Transcription Factor Induced by Interleukins (IL)-13 and -4 Leading to Induction of 15-Lipoxygenase ( 15-LO ) in Human Cells....Pages 469-481
Divergence in Intracellular Signaling Between Interleukin-4 (IL -4) And IL-13 in Human Cells Localizes To Monomeric/Dimeric Expression of A Transcription Factor, The Lupus Autoantigen 70/80, Induced by Both Cytokines....Pages 483-489
Role of Phosphatidylethanolamine in G Protein-Coupled Receptor-Associated Signal Transduction....Pages 491-496
 The P21-Activated Protein Kinases (Paks) Receive And Integrate Messages From A Variety of Signaling Pathways ....Pages 497-502
Signaling Pathways for Tnfa-Induced Cox-2 Expression: Mediation Through Map Kinases And Nfkb, And Inhibition By Certain Nonsteroidal Anti-Inflammatory Drugs....Pages 503-508
12(S)-Hete, Pleiotropic Functions, Multiple Signaling Pathways....Pages 509-515
Formation of Novel D-Ring and E-Ring Isoprostane-Like Compounds (D 4 /E 4 -Neuroprostanes) in Vivo From Docosahexaenoic Acidt....Pages 519-524
Regulation of Cell-Substrate Adhesion by the Lipoxygenase and Cyclooxygenase Branches of Arachidonic Acid Metabolism....Pages 525-529
Development of Enzyme Immunoassays for 5,6-, 8,9-,11,12-, And 14,15- Eets and the Corresponding Dhets....Pages 531-536
Enzyme Immunoassays for 15-F2t Isoprostane-M, an Urinary Biomarker for Oxidant Stress....Pages 537-541
Biphasic Regulation of Leukocyte Trafficking by Lipoxins....Pages 543-549
Pantothenic Acid: an Organ-Specific Pro-Oxidant Vitamin¶....Pages 551-555
Linoleate Diol Synthase and PGH Synthase - A New Gene Family of Fatty Acid Heme Dioxygenases?....Pages 557-561
Eicosanoids regulation of transcription factors in pc-3 prostate cancer cells.....Pages 563-568
Non-Prostaglandin Effects of Aspirin III and Salicylate: Inhibition of Integrin-dependent Human Neutrophil Aggregation and Inflammation in COX 2- and NFκB (P105)-Knockout Mice....Pages 571-577
Dietary Epa Reduces Tumor Load in Apc Min/+ Mice by Altering Arachidonic Acid Metabolism, But Conjugated Linoleic Acid, Gamma- And Alpha-Linolenic Acids Have No Effect....Pages 579-584
The Regulation of Cyclooxygenase-1 and -2 in Knockout Cells and Mice....Pages 585-591
Prostanoids In Health and Disease; Lessons From Receptor-Knockout Mice....Pages 593-597
Back Matter....Pages 599-630