Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4

Front Matter....Pages i-xix
Front Matter....Pages 1-1
Function and Regulation of Prostaglandin Synthase 2....Pages 3-8
Regulation of Cyclooxygenase-2 by the Activated p38 Mapk Signaling Pathway....Pages 9-15
Fatty Acid Cyclooxygenase Induction and Prostaglandin D Synthesis in a Human Megakaryoblastic Cell Line CMK Differentiated by Phorbol Ester....Pages 17-21
Eicosanoid Metabolism in Human Platelets is Modified by Albumin....Pages 23-27
Diverse Functional Coupling of Prostanoid Biosynthetic Enzymes in Various Cell Types....Pages 29-35
Regulation of Prostaglandin, Leukotriene, and Platelet-Activating Factor Metabolism in Mast Cells....Pages 37-42
Lipid Peroxides and Neuronal Plasticity....Pages 43-48
Secretion of Lipocalin-Type Prostaglandin D Synthase (β-Trace) from Human Heart to Plasma During Coronary Circulation....Pages 49-54
Lipocalin-type Prostaglandin D Synthase (β-Trace) Binds Non- Substrate Lipophilic Ligands....Pages 55-60
Features of Mammalian Lipoxygenases....Pages 61-66
Identification and Characterization of an Enhancer Sequence in the Promoter Region of Human 15-Lipoxygenase ( 15-LO ) Gene....Pages 67-74
Cytokine Induced Regulation of 15-Lipoxygenase and Phospholipid Hydroperoxide Glutathione Peroxidase in Mammalian Cells....Pages 75-81
Investigation of a Second 15 S -Lipoxygenase in Humans and its Expression in Epithelial Tissues....Pages 83-89
Sequence Determinants for the Positional Specificity of Mammalian and Plant Lipoxygenases....Pages 91-97
X-Ray Absorption Studies into the iron Ligand Sphere of Plant and Animal Lipoxygenases....Pages 99-104
Regulation of 5-Lipoxygenase mRNA Expression in the Human Monocytic Cell Line Mono Mac 6 by Transforming Growth Factor-ß and 1,25-Dihydroxyvitamin D 3 ....Pages 105-111
Front Matter....Pages 113-113
Comparison of Prostaglandin H Synthase-1 and -2 Structural Stabilities....Pages 115-118
Modulation of the Expression of the Cyclooxygenase 1 and 2 Genes in Rat Mammary Glands: Role of Hormonal Status and Dietary Fat....Pages 119-124
Regulation of Cerebrovascular Cyclooxygenase-2 by Pro- and Anti-Inflammatory Cytokines....Pages 125-129
Visualization and Quantitation of Cyclooxygenase-1 and -2 Activity by Digital Fluorescence Microscopy.....Pages 131-137
Front Matter....Pages 113-113
Discovery of a New Class of Selective Cyclooxygenase-2 (COX-2) Inhibitor that Covalently Modifies the Isozyme....Pages 139-143
Mitigation of Arthritis by High-Dose Administration of a COX-2 Inhibitor in the Collagen-Induced Arthritis Model in the Mouse....Pages 145-150
Indomethacin Inhibition of Pristane Plasmacytomagenesis in Genetically Susceptible Inbred Mice....Pages 151-156
Role of COX-2 Inhibition on the Formation and Healing of Gastric Ulcers Induced by Indomethacin in the Rat....Pages 157-163
Regulation of in Vivo Prostaglandin Biosynthesis by Glutathione....Pages 165-168
Different Effects of Reactive Nitrogen Intermediates on Prostaglandin E 2 Synthesis in Cultured Rat Microglia and Raw 264.7 Cells....Pages 169-174
Front Matter....Pages 175-175
Activation of cPLA 2 in Vascular Smooth Muscle....Pages 177-182
Role of Type IIA Secretory Phospholipase A 2 in Arachidonic Acid Metabolism....Pages 183-188
Phospholipase A 2 is Involved in Chemotaxis Of Human Leukocytes....Pages 189-197
Supression of Acute Experimental Inflammation by Antisense Oligonucleotides Targeting Secretory Phospholipase A 2 (sPLA 2 ) IN VITRO and IN VIVO Experiments....Pages 199-207
Comparison Of Recombinant Types IIA, V And IIC Phospholipase A 2 S, the Three Related Mammalian Secretory Phospholipase A 2 Isozymes....Pages 209-214
Respective Roles of the 14 KDA and 85 KDA Phospholipase A 2 Enzymes in Human Monocyte Eicosanoid Formation....Pages 215-219
Modulation of Long-Term Potentiation in the CA1 Area of Rat Hippocampus by Platelet-Activating Factor....Pages 221-227
Front Matter....Pages 229-229
Ppars: Nuclear Receptors for Fatty Acids Eicosanoids, and Xenobiotics....Pages 231-236
Molecular Cloning and Characterization of Leukotriene B 4 Receptor....Pages 237-244
Determinants of Receptor Subtype Specificity in the LPA-Like Lipid Mediator Family....Pages 245-251
Subunits and Cellular Occurrence of the 12(S)-Hete Binding Complex....Pages 253-258
A Subfamily of G Protein-Coupled Cellular Receptors for Lysophospholipids and Lysosphingolipids....Pages 259-264
Evidence for Involvement of Prostaglandin I 2 as a Major Nociceptive Mediator in Acetic Acid-Induced Writhing Reaction: a Study Using IP-Receptor Disrupted Mice....Pages 265-268
Local Anesthetic Effects on TXA 2 Receptor Mediated Platelet Aggregation Using Quenched Flow Aggregometry....Pages 269-276
Front Matter....Pages 229-229
Volatile and Local Anesthetics Interfere with Thromboxane A 2 Receptors Recombinantly Expressed in Xenopus Oocytes....Pages 277-283
Front Matter....Pages 285-285
Aspirin-Triggered 15-Epi-Lipoxin A 4 and Novel Lipoxin B 4 Stable Analogs Inhibit Neutrophil-Mediated Changes in Vascular Permeability....Pages 287-293
Cleavage of Leukotriene D 4 in Mice with Targeted Disruption of a Membrane-Bound Dipeptidase Gene....Pages 295-300
γ-Glutamyl Leukotrienase Cleavage of Leukotriene C 4 ....Pages 301-306
LTE 4 Blood Levels in Infants with Congenital Heart Lesions....Pages 307-311
Evaluation of the Pharmacological Activity of the Pure Cysteinyl-Leukotriene Receptor Antagonists CGP 45715A (Iralukast) and CGP 57698 in Human Airways....Pages 313-318
Evidence for a Carbocation Intermediate in the Enzymatic Transformation of Leukotriene A 4 Into Leukotriene B 4 ....Pages 319-325
A Random Rapid Equilibrium Mechanism for Leukotriene C 4 Synthase....Pages 327-332
Front Matter....Pages 333-333
Formation of Reactive Products of the Isoprostane Pathway: Isolevuglandins and Cyclopentenone Isoprostanes....Pages 335-341
Formation of Novel Isoprostane-Like Compounds from Docosahexaenoic Acid....Pages 343-347
Front Matter....Pages 349-349
cDNA Cloning, Expression and Chromosomal Localization of Two Human Lysophosphatidic Acid Acyltransferases....Pages 351-356
The First Cloned and Identified Lysophospholipid (LP) Receptor Gene, VZG-1 : Implications for Related Receptors and the Nervous System....Pages 357-362
Front Matter....Pages 363-363
Involvement of Protein Kinase C, P38 Map Kinase and ERK in Arachidonic Acid-Stimulated Superoxide Production in Human Neutrophils....Pages 365-370
13(S)-Hpode Augments Epidermal Growth Factor Signal Transduction by Attentuating EGF Receptor Dephosphorylation....Pages 371-376
Role of Lipoxygenase in the Regulation of Glucose Transport in Aortic Vascular Cells....Pages 377-383
Functions of the P21-Activated Protein Kinases (Paks) in Neutrophils and their Regulation by Complex Lipids....Pages 385-390
Inhibition of Neurofibromin and p120 GTPASE Activating Protein (GAP) by Dietary Fatty Acids....Pages 391-398
Front Matter....Pages 399-399
Spinal Synthesis and Release of Prostanoids After Peripheral Injury and Inflammation....Pages 401-408
Prostaglandin E2 as a Modulator of Lymphocyte Mediated Inflammatory and Humoral Responses....Pages 409-412
Lipid Mediators Stimulate Reactive Oxygen Species Formation in Immortalized Human Keratinocytes....Pages 413-418
Front Matter....Pages 399-399
Nitric Oxide Synthesis is Increased in Periodontitis....Pages 419-424
Augmentation Effects of High Glucose on Endotoxin-Induced Nitric Oxide Production in Murine Macrophages....Pages 425-430
1,2-Diacylglycerol Hydroperoxide Induces the Generation and Release of Superoxide Anion from Human Polymorphonuclear Leukocytes....Pages 431-436
Kinetic Evaluation of Endogenous Leukotriene B4 Ande4 Acute Activation of Inflammatory Cells in the Rabbit....Pages 437-441
Lipopolysaccharide- and Liposome-Encapsultaed MTP-PE- Induced Formation of Eicosanoids, Nitric Oxide and Tumor Necrosis Factor-α in Macrophages....Pages 443-448
LTA4 Hydrolase Expression During Glomerular Inflammation: Correlation of Immunohistochemical Localization with Cytokine Regulation....Pages 449-454
12-Lipoxygenase Products Increase Monocyte: Endothelial Interactions....Pages 455-460
Front Matter....Pages 461-461
Linoleic Acid Metabolites in Health and Disease....Pages 463-469
Toxicity of Linoleic Acid Metabolites....Pages 471-477
Dramatic Increase of Linolelic Acid Peroxidation Products by Aging, Atherosclerosis, and Rheumatoid Arthritis....Pages 479-483
Modulation of Atherogenesis by Dietary Gamma-Linolenic Acid....Pages 485-491
The Selective Cytotoxicity of γ-Linolenic Acid (GLA) is Associated with Increased Oxidative Stress....Pages 493-498
γ-Linolenic Acid (GLA)-Mediated Cytotoxicity in Human Prostate Cancer Cells....Pages 499-504
Five-Lipoxygenase Inhibitors Reduce Panc-1 Survival: Synergism of MK886 with Gamma Linolenic Acid....Pages 505-510
Front Matter....Pages 511-511
Enzymological and Molecular Biological Studies on Anandamide Amidohydrolase....Pages 513-518
A Pathway for the Biosynthesis of Fatty Acid Amides....Pages 519-525
Investigation of Structural Analogs of Prostaglandin Amides for Binding to and Activation of CB 1 and CB 2 Cannabinoid Receptors in Rat Brain and Human Tonsils....Pages 527-533
Hepoxilin A 3 is Metabolized Into its ω-Hydroxy Metabolite by Human Neutrophils....Pages 535-538
Oxidation of Arachidonate Containing Glycerophospholipids in Intact Red Blood Cells and Red Blood Cell Membranes with Tert-Butylhydroperoxide....Pages 539-545
Cannabinoid Modulation of Neuronal Activity in Adult Rat Hippocampus....Pages 547-552
Front Matter....Pages 553-553
Cyclooxygenase-Independent Induction of P2L WAF-1/CIP1 , Apoptosis and Differentiation by L-745, 337 and Salicylate in HT-29 Colon Cancer Cells....Pages 555-561
Modulation of Cellular Proliferation and Induction of Apoptosis in a Human Lymphoma Cell Line After Treatment with Selective Lipoxygenase Inhibitors....Pages 563-568
Mechanisms of Peroxynitrite-Induced Apoptosis in HL-60 Cells....Pages 569-575
Central Role of Arachidonate 5-Lipoxygenase in the Regulation of Cell Growth and Apoptosis in Human Prostate Cancer Cells....Pages 577-582
Role of Autocrine Motility Factor in a 12-Lipoxygenase Dependent Anti-Apoptotic Pathway....Pages 583-590
Front Matter....Pages 591-591
The Possible Involvement of 15-Lipoxygenase/Leukocyte Type 12- Lipoxygenase in Colorectal Carcinogenesis....Pages 593-598
Induction of Leukotriene B 4 Metabolism by Cancer Chemopreventive Agents....Pages 599-605
Intestinal Tumor Load in the Min /+ Mouse Model is not Correlated with Eicosanoid Biosynthesis....Pages 607-615
12-Lipoxygenase Expression in Human Melanoma Cell Lines....Pages 617-622
Platelet-Type 12-Lipoxygenase Regulates Angiogenesis in Human Prostate Carcinoma....Pages 623-630
Prostaglandin H Synthase and Lipoxygenase Mediated Activation of Xenobiotics in Platelets....Pages 631-637
Characterization of Two Spliced Variants of Human Phosphatidic Acid Phosphatase cDNAs that are Differentially Expressed in Normal and Tumor Cells....Pages 639-646
Eicosapentaenoic Acid Alters Manganese Superoxide Dismutase Immunoreactive Protein Levels in Normal But not Maligant Central Nervous System Derived Cells....Pages 647-653
Gamma Radiation and Release of Norepinephrine in the Hippocampus....Pages 655-659
Front Matter....Pages 661-661
(3R)-Hydroxy-Oxylipins—A Novel Family of Oxygenated Polyenoic Fatty Acids of Fungal Origin....Pages 663-668
Eicosanoids in the Brain of Warm- and Cold-Acclimated Bullfrogs....Pages 669-674
Production of 3-Hydroxy Fatty Acids by the Yeast Dipodascopsis Uninucleata. Biological Implications....Pages 675-677
Catalytic Properties of Linoleate Diol Synthase of the Fungus Gaeumannomyces Graminis: A Comparison with PGH Synthases....Pages 679-685
Back Matter....Pages 687-699