Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2: Part A

Front Matter....Pages i-xxv
Front Matter....Pages 1-1
Regulation of Phosphoinositide Phospholipases by G-Proteins....Pages 3-8
The Effects of Group II Phospholipase A 2 on Ras -Induced Metastasis....Pages 9-17
Activation of Ca 2+ -Sensitive Cytosolic Phospholipase A 2 (cPLA 2 ) in Human Platelets....Pages 19-24
Involvement of Reactive Oxygen Species in Phospholipase A 2 Activation: Inhibition of Protein Tyrosine Phosphatases and Activation of Protein Kinases....Pages 25-30
High Molecular Weight Phospholipase A 2 : Its Occurrence and Quantification in Human Colon Cancer and Normal Mucosa....Pages 31-37
Front Matter....Pages 39-39
 (S) -Type Lipoxygenase and Cyclooxygenase Reaction Box Models Characterizing the Stereochemistry of the Dioxygenation Reaction....Pages 41-45
Activation of 5-Lipoxygenase in Whole Polymorphonuclear Leukocytes by Arachidonic Acid: Evidence of Cytosolic Active Enzyme....Pages 47-56
Intracellular Distribution, Activity, and Ca 2+ -Dependent Translocation of 12-Lipoxygenase in Lewis Lung Tumor Cells....Pages 57-64
Cloning and Sequencing of Prostaglandin H Synthetase from Rat Tracheal Epithelial Cells: Structural Evidence that a TPA Regulated mRNA Codes for the Rat Ortholog of Murine PHS-1....Pages 65-70
Non-Enzymatic Rearrangement of Leukotriene A 4 to 5-Keto-(7E,9E,11Z,14Z)-Eicosatetraenoic Acid in Aqueous Media....Pages 71-76
Bromoacetamido-Analogs of Indomethacin and Mefenamic Acid Affinity-Label Prostaglandin H 2 Synthase at Two Sites....Pages 77-84
Regulation of Eicosanoid Synthesis in Liver Macrophages....Pages 85-92
Comparison of Arachidonic Acid Metabolism by Normal, Pre-Cancerous and Neoplastic Epithelial Cell Lines of the Upper Aerodigestive Tract....Pages 93-98
Induction of Prostaglandin Endoperoxide Synthase-1 (Cox-1) in a Human Promonocytic Cell Line by Treatment with the Differentiating Agent TPA....Pages 99-106
X-Ray Crystallographic Study of the Structure of Prostaglandin H Synthase....Pages 107-111
Properties of Prostacyclin Synthase....Pages 113-119
Regulation of Prostaglandin H Synthase-1 Gene Expression....Pages 121-126
Mammalian Arachidonate 12-Lipoxygenases....Pages 127-131
The Three-Dimensional Structure of Soybean Lipoxygenase-1: An Arachidonic Acid 15-Lipoxygenase....Pages 133-138
Purification and Characterization of the Epidermal 8(S)Lipoxygenase....Pages 139-144
Front Matter....Pages 39-39
The Effect of 5-Lipoxygenase-Activating Protein (Flap) on Substrate Utilization by 5-Lipoxygenase....Pages 145-151
Leukotriene A 4 Hydrolase: Differential Inhibition of the Catalytic Activities by Divalent Cations....Pages 153-157
Regulation of 12(S)-Hete Production in Tumor Cells....Pages 159-166
Distribution of Cox-1 and Cox-2 in Normal and Inflamed Tissues....Pages 167-170
Examination of Prostaglandin H Synthase-1 Topology in the Endoplasmic Reticulum Membrane....Pages 171-175
Coordinate Regulation of the Inducible forms of Prostaglandin Synthase and Nitric Oxide Synthase in Fibroblasts and Macrophages....Pages 177-182
Molecular Cloning of Prostacyclin Synthase from Bovine Endothelial Cells....Pages 183-187
Interaction of PGH Synthase Isozymes-1 and -2 with Nonsteroidal Anti-Inflammatory Drugs....Pages 189-196
Front Matter....Pages 197-197
Dual Effect of Propranolol on the Human Platelet Activation by Thrombin: Potentiation of Free Intracellular Ca 2+ Mobilization and Inhibition of Phospholipase D Activity....Pages 199-205
Molecular Diversity of Prostanoid Receptors; Subtypes and Isoforms of Prostaglandin E Receptor....Pages 207-213
Molecular Characterization and Physiological Functions of PAF Receptors....Pages 215-221
Identification of the FP-Receptor as a Discrete Entity by Radioligand Binding in Biosystems that Exhibit Different Functional Rank Orders of Potency in Response to Prostanoids....Pages 223-227
Cellular Activation by Thromboxane A2 and 8 — EPI — PGF 2α ....Pages 229-233
Modification on Ligand Binding to TXA 2 /PGH 2 Receptors by Diethylpyrocarbonate....Pages 235-240
Prostaglandin Receptors Involved in Inflammatory Events....Pages 241-245
LTB 4 Receptor Antagonists Exacerbate T Lymphocyte-Mediated Delayed Hypersensitivity in Guinea Pigs....Pages 247-251
Isolation and Cloning of Human Peroxisome Proliferator Activated Receptor Gamma CDNA....Pages 253-260
Structure and Localization of the Rabbit Prostaglandin EP3 Receptor....Pages 261-268
Prostaglandin Regulation of Gene Expression and Growth in Normal and Malignant Tissues....Pages 269-278
Distinct Signaling Pathways Mediate Induction of c-fos by PGE 2 in Glomerular Mesangial Cells....Pages 279-286
Front Matter....Pages 197-197
Cytosolic 12(S)-Hydroxy-5,8,10,14-Eicosatetraenoic Acid Binding Sites in Carcinoma Cells....Pages 287-293
Front Matter....Pages 295-295
Dag Second Messengers: Molecular Switches and Growth Control....Pages 297-303
Sphingolipid Second Messengers: Tumor Suppressor Lipids....Pages 305-312
The Role of Protein Kinase C in Signal Transduction, Growth Control and Lipid Metabolism....Pages 313-321
Tumor Responsiveness to the Metastasis-Stimulatory Effects of Prostaglandin E 2 is Restricted by Protein Phosphatases....Pages 323-328
Interactions Between Specific Phosphoproteins During Modulation of Prostacyclin Secretion in Cultured Bovine Aortic Endothelial Cells....Pages 329-337
The Role of Lipid Peroxidation Products in the Regulation of Protein Kinase C Activity in Vitro....Pages 339-348
Role of Protein Kinase C and Phosphatases in 12(S)-Hete-Induced Tumor Cell Cytoskeletal Reorganization....Pages 349-361
Front Matter....Pages 363-363
PX-52, a Novel Inhibitor of 14 kDa Secretory and 85 kDa Cytosolic Phospholipases A 2 ....Pages 365-373
Hepoxilin A 3 Inhibits Agonist-Evoked Rise in Free Intracellular Calcium in Human Neutrophils....Pages 375-380
The Discovery of LY293111, a Novel, Potent and Orally Active Leukotriene B 4 Receptor Antagonist of the Biphenylphenol Class....Pages 381-386
Inhibition of Leukotriene B 4 (LTB 4 ) in Human Neutrophils by L-Threo-Dihydrosphingosine....Pages 387-392
Front Matter....Pages 393-393
Aspirin and Gastrointestinal Cancer....Pages 395-402
Monohydroxylated Fatty Acids in Mouse Epidermis Papilloma Quantification and Stereochemical Characterization....Pages 403-407
Negative Growth Regulation of Oncogene-Transformed Mammary Epithelial Cells by Tumor Inhibitors....Pages 409-418
Different Expression of Prostaglandin-H Synthase Isozymes and Lipoxygenases During Multistage Carcinogenesis in Mouse Skin....Pages 419-424
Expression of Two cPLA 2 Isoforms in Mouse Epidermis in Vivo....Pages 425-431
Regulation of Arachidonic Acid Release and Metabolism by Tumor Promoters....Pages 433-438
Effect of the Peroxisome Proliferators Ciprofibrate and Perfluorodecanoic Acid on Eicosanoid Concentrations in Rat Liver....Pages 439-445
Front Matter....Pages 447-447
A Mitogenic and Hormonal Signalling Network Regulate Mammalian Cell Division Commitment Time....Pages 449-454
Front Matter....Pages 447-447
Growth Inhibitory Effects of Thromboxane Antagonists on Breast Cancer Cell Lines: A Preliminary Study....Pages 455-460
The Rise and Fall of Ceramide and 1,2-Diacylglycerol (DAG): Modulation by Transforming Growth Factor-β1 (TGFβ1) and by Epidermal Growth Factor (EGF)....Pages 461-472
Antioxidant Defence Mechanisms and PGE Secretion by Different Types of Transformed and Tumor Cells: In Vivo Selective Advantages....Pages 473-477
The Relationship Between Farnesylation and Carcinogenesis: The Effect of Lovastatin on Fibroblast Proliferation....Pages 479-486
Eicosanoid Production and Growth Regulation in Rat Intestinal Epithelial Cells....Pages 487-493
Role of Archidonic Acid and Linoleic Acid Metabolism in Epidermal Growth Factor Initiated Proliferation of Syrian Hamster Embryo Fibroblasts....Pages 495-500
Phenylacetate and Phenylbutyrate as Novel, Nontoxic Differentiation Inducers....Pages 501-505
Structural Requirements for Enhancement of EGF-Dependent DNA Synthesis by Oxygenated Metabolltes of Linoleic Acid....Pages 507-512
Decreased DNA Synthesis in SCC-25 Cells with ETYA and SC41661....Pages 513-516
Liver Fatty Acid Binding Protein and Mitogenesis in Transfected Hepatoma Cells....Pages 517-524
Induction of 12-Lipoxygenase Expression by Epidermal Growth Factor is Mediated by Protein Kinase C in A431 Cells....Pages 525-529
Prostaglandin F 2α (PGF 2α ) Triggers Protein Kinase C (PKC) and Tyrosine Kinase Activity in Cultured Mammalian Cells....Pages 531-538
Mechanisms of the Selective Cytotoxic Actions of Certain Essential Fatty Acids....Pages 539-544
Eicosanoids, Cancer Metastasis, and Gene Regulation: An Overview....Pages 545-555