Effects of Mineral Dusts on Cells

Front Matter....Pages I-XII
Effects of Cigarette Smoke on Uptake of Asbestos and Iron Oxide by Rat Tracheal Explants....Pages 1-5
Cytotoxicity of Asbestos and Calciumsilicates to Various Lung Epithelial Cell Types in Vitro....Pages 7-13
Injurious Effects of Mineral Dust-elicited Bronchoalveolar Leukocytes on Epithelial Cells in vitro : The Role of Extracellular Matrix Components....Pages 15-21
Toxicity of Chrysotile Asbestos through Surface Modification with Chelating Agents....Pages 23-25
A Comparison of the In Vivo and In Vitro Toxicity of Fibrous and Non-Fibrous Silicon Nitride....Pages 27-35
Membranolytic Activity and Morphological Characterization of Palygorskite and Sepiolite....Pages 37-48
Mineral Surface-Specific Differences in the Adsorption and Enzymatic Removal of Surfactant and Their Correlation with Cytotoxicity....Pages 49-56
Bronchoalveolar Lavage Cells in Occupational Exposure to Mineral Fibers....Pages 57-64
Alveolar Macrophages Secretory Dysfunctions in Coal Workers’s Pneumoconiosis. Comparison Between Simple Pneumoconiosis and Progressive Massive Fibrosis.....Pages 65-71
Cellularity in Bronchoalveolar Lavage in Cement Dust Aggression....Pages 73-79
Carborundum Pneumoconiosis....Pages 81-84
Influence of Physicochemical Properties of Beryllium and Nickel Compounds on Cultured Cell Toxicity....Pages 85-92
Comparative Study of the Effect of Various Fibres on the Secretion of Plasminogen Activator by Murine Peritoneal Macrophages....Pages 93-100
Release of lnterleukin-1 and Tumor Necrosis Factor by Rat Alveolar Macrophages after In Vivo or In Vitro Exposure to Mineral Dusts....Pages 101-108
The Effect of Aramid and Metaphosphate Fibers on Macrophage Viability and Function....Pages 109-114
Effects of Nicotinamide on the Cytotoxicity of Mineral Dusts Towards Pulmonary Alveolar Macrophages....Pages 115-122
Long-Term Effect of 3Methylcholanthrene-Coated Asbestos Fibres on the Immune Status of F1(NZB*C57B1/6) Mice....Pages 123-131
Production of Growth Factors by Rat Pleural Mesothelial Cells In Vivo or In Vitro Transformed by Chrysotile Fibers....Pages 133-140
Mutagenicity of Asbestos and Erionite in a Salmonella Tester Strain of TA102....Pages 141-148
Induction of Sister Chromatid Exchanges by Fibrous Dusts Alone and in Combination with Other Xenobiotics in Chinese Hamster Cells....Pages 149-156
Pleural and Parenchymal Responses in Rats to Short-Term Inhalation Exposures to Erionite, Crocidolite, Chrysotile, Silica and Titanium Dioxide....Pages 157-164
 In Vitro Responses of Canine Alveolar Lymphocytes to BeSO 4 After Inhalation Exposure to BeO....Pages 165-172
Oxidants, Antioxidants and Monokines in the Pathogenesis of Coal Workers’ Pneumoconiosis. Tumor Necrosis Factor as a Mediator in Lung Fibrosis....Pages 173-180
Use of Chemiluminescence Assays to Monitor the Surface Characteristics and Biological Reactivity of Freshly Fractured vs Aged Silica....Pages 181-188
Production of free radicals by non-fibrous materials in a cell-free buffer medium....Pages 189-196
Detoxified Crocidolite Exhibits Reduced Radical Generation which could Explain its Lower Toxicity: ESR and Mossbauer Studies....Pages 197-204
The Formation of Oxygen Reactive Radicals at the Surface of the Crushed Quartz Dusts as a Possible Cause of Silica Pathogenicity....Pages 205-214
Arachidonic Acid Metabolite Production by Alveolar Macrophages Cultured in Gazeous Phase. Effects of NO 2 and Diesel Exhaust....Pages 215-222
Superoxide Anion Production Induced by Chrysotile Asbestos in the Guinea Pig Alveolar Macrophage....Pages 223-229
Altered Calcium Homeostasis and Mineral Dust Toxicity....Pages 231-238
Formation of 8-Hydroxydeoxyguanosine in DNA by MMMF....Pages 239-246
Effect Of Chrysotile, Amosite and Crocidolite on the Oxidative Burst of Rabbit Alveolar Macrophages....Pages 247-255
Production of Radicals Arising from Surface Activity of Fibrous Minerals....Pages 257-264
Potential Role of Silicon-Oxygen Radicals in Acute Lung Injury....Pages 265-272
Oxygenated Radical Formation by Fresh Quartz Dust in a Cell-Free Aqueous Medium and Its Inhibition by Scavengers....Pages 273-280
Interaction of Quartz with Bovine Alveolar Macrophages: Studies on Cytotoxicity, Electrophoretic Mobility and Subcellular Components....Pages 281-288
Degradation of an Extracellular Matrix Component by Bronchoalveolar Leukocytes In Vitro : Modulation by Mineral Dust....Pages 289-295
Silica Induced Alveolar Leucocytosis: Modulation by Mepacrine....Pages 297-304
Altered Functional Expression of Alveolar Macrophage Subpopulations after Serpentine and Amphibole Asbestos Exposure....Pages 305-312
Particle Induced In vitro Chemotaxis of Alveolar Macrophages (AM) and Neutrophils and In Vivo Effects....Pages 313-320
Consequences of MMMF Inhalation on Lung and Pleural Cavity Cell Populations....Pages 321-328
The Role of Alveolar Macrophage Activation in the Response to Mineral Fibers....Pages 329-335
 In Vitro Studies of Leukocytes Lavaged from the Lungs of Rats Following the Inhalation of Mineral Dusts....Pages 337-345
Predictive Value of In Vitro Pulmonary Macrophage Functional Assays to Assess In Vivo Clearance of Inhaled Particles....Pages 347-357
Leukotriene B 4 and Tumor Necrosis Factor Production after in vitro Exposure of Rat Alveolar Macrophages to Mineral Dust: Potential Role in Fibrogenesis....Pages 359-366
Modulation of Macrophage-Mediated Cytotoxicity by Toxic Particles....Pages 367-374
Effects of Asbestos Fibres on Some Aspects of the Cell Second Messenger System....Pages 375-381
A Model for the Influence of Inhaled Mineral Fibers on the Cellular Burden of Polycyclic Aromatic Hydrocarbons in the Lung....Pages 383-388
Oncogenic Transformation by Asbestos Fibers and Radon-Simulated Alpha Particles....Pages 389-397
Studies on Cell Cycle of Rat Pleural Mesothelial Cells Submitted to Direct or Indirect Hit by Chrysotile Fibres....Pages 399-405
Effects of 3Methylcholanthrene-coated Asbestos on Hematological Status of F1 (NZB*C57B1/6) Mice....Pages 407-414
Occurrence and Morphology of Tumours Induced in Nude Mice Transplanted with Pleural Mesothelial Cells In Vitro Treated with Chrysotile or Benzo 3–4 Pyrene....Pages 415-422
Cytotoxic, Hemolytic and Mutagenic Issue caused by Chrysotile-Asbestos In Vitro....Pages 423-432
Effects of Asbestos on Specific Binding of Phorbol Ester Tumor Promoter and Protein Kinase C Activity in Hamster Tracheal Epithelial (HTE) Cells....Pages 433-437
Questions to the Cell Biologists and Proposals for a Definition and Classification of Carcinogenic Fibers Derived from Animal Studies....Pages 439-444
Risk Factors of Asbestos-Related Cancers....Pages 445-454
Mesothelioma Threshold....Pages 455-464
Summary and Closing Remarks....Pages 465-470
Back Matter....Pages 471-472