Effect-Directed Analysis of Complex Environmental Contamination

Front Matter....Pages i-xviii
Early Evolution of the Toxicity Identification Evaluation Process: Contributions from the United States Environmental Protection Agency Effluent Testing Program....Pages 1-18
Recent Developments in Whole Sediment Toxicity Identification Evaluations: Innovations in Manipulations and Endpoints....Pages 19-40
Considerations for Incorporating Bioavailability in Effect-Directed Analysis and Toxicity Identification Evaluation....Pages 41-68
Diagnostic Tools for Effect-Directed Analysis of Mutagens, AhR Agonists, and Endocrine Disruptors....Pages 69-82
Separation Techniques in Effect-Directed Analysis....Pages 83-118
Simultaneous Screening and Chemical Characterization of Bioactive Compounds Using LC-MS-Based Technologies (Affinity Chromatography)....Pages 119-141
Advanced GC–MS and LC–MS Tools for Structure Elucidation in Effect-Directed Analysis....Pages 143-165
Computer Tools for Structure Elucidation in Effect-Directed Analysis....Pages 167-198
Effect-Directed Analysis of Mutagens in Ambient Airborne Particles....Pages 199-235
Effect-Directed Analysis of Endocrine Disruptors in Aquatic Ecosystems....Pages 237-265
Effects-Directed Studies of Pulp and Paper Mill Effluents....Pages 267-283
Effect-Directed Analysis of Ah-Receptor Mediated Toxicants, Mutagens, and Endocrine Disruptors in Sediments and Biota....Pages 285-313
Ecological Relevance of Key Toxicants in Aquatic Systems....Pages 315-339
Back Matter....Pages 341-345