Dyskinesia: Research and Treatment

Front Matter....Pages I-IX
Front Matter....Pages 1-1
Brain Dopamine Receptors in Schizophrenia and Tardive Dyskinesia....Pages 2-8
Receptor-Binding Profiles of Neuroleptics....Pages 9-18
Functional Classification of Different Dopamine Receptors....Pages 19-30
Pharmacological Properties of Presynaptic Dopamine Receptor Agonists....Pages 31-38
Influence of GABA Mimetics and Lithium on Biochemical Manifestations of Striatal Dopamine Target Cell Hypersensitivity....Pages 39-45
New Aspects on the Role of Dopamine, Acetylcholine, and GABA in the Development of Tardive Dyskinesia....Pages 46-57
Differential Effects of Dopamine D-1 and D-2 Agonists and Antagonists in 6-Hydroxydopamine-Lesioned Rats....Pages 60-61
Front Matter....Pages 63-63
Is Tardive Dyskinesia a Unique Disorder?....Pages 64-71
Tardive Dyskinesia: Prevalence, Incidence, and Risk Factors....Pages 72-78
Involuntary Disorders of Movement in Chronic Schizophrenia — The Role of the Illness and Its Treatment....Pages 79-87
Tardive Dyskinesia: Reversible and Irreversible....Pages 88-97
Pathophysiological Mechanisms Underlying Tardive Dyskinesia....Pages 98-103
Chemical and Structural Changes in the Brain in Patients with Movement Disorder....Pages 104-110
Medical Treatment of Dystonia....Pages 111-117
The Effect of Dopamine Antagonists in Spontaneous and Tardive Dyskinesia....Pages 118-121
GABA Dysfunction in the Pathophysiology of Tardive Dyskinesia....Pages 122-127
Clinical Activity of GABA Agonists in Neuroleptic- and L -Dopa-Induced Dyskinesia....Pages 128-136
Tardive Dyskinesia: Nondopaminergic Treatment Approaches....Pages 137-144
Pathophysiology of L -Dopa-Induced Abnormal Involuntary Movements....Pages 145-159
Prevalence of Tardive Dyskinesia in a Clinic Population....Pages 162-172
Front Matter....Pages 173-173
Differential Alteration of Striatal D-1 and D-2 Receptors Induced by the Long-Term Administration of Haloperidol, Sulpiride or Clozapine to Rats....Pages 174-181
Pharmacological Differentiation of Dopamine D-1 and D-2 Antagonists After Single and Repeated Administration....Pages 182-190
Pathophysiology of Tardive Dyskinesia....Pages 191-193
Intermittent Treatment with Droperidol, a Short-Acting Neuroleptic, Increases Behavioral Dopamine Receptor Sensitivity....Pages 194-199
Induction and Reversal of Dopamine Dyskinesia in Rat, Cat, and Monkey....Pages 200-210
Behavioral Effects of Long-Term Neuroleptic Treatment in Cebus Monkeys....Pages 211-216
Induction of Tardive Dyskinesia in Cebus apella and Macaca speciosa Monkeys: A Review....Pages 217-223
Back Matter....Pages 225-230